The United States spends an excess $1.5 trillion annually on health care compared to other wealthy countries—yet the amount of time that Americans live in good health ranks a lowly 68th in the world. At the heart of the problem is Big Pharma, which funds most clinical trials and therefore controls the research agenda, withholds the real data from those trials as corporate secrets, and shapes most of the information relied upon by health care professionals.

While researching the toxic and addictive properties of sugar for Fat Chance, Robert Lustig made an alarming discovery - our pursuit of happiness is being subverted by a culture of addiction and depression from which we may never recover. Dopamine is the "reward" neurotransmitter that tells our brains we want more; yet every substance or behavior that releases dopamine in the extreme leads to addiction. Serotonin is the "contentment" neurotransmitter that tells our brains we don't need any more; yet its deficiency leads to depression.

Progressives claimed they knew how to solve homelessness, inequality, and crime. But in cities they control, progressives made those problems worse.

An eye-opening report from an award-winning author and former New York Times reporter reveals the link between teenage marijuana use and mental illness, and a hidden epidemic of violence caused by the drug - facts the media has ignored as the US rushes to legalize cannabis.

In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched.

When a small vial arrives in her mailbox from "Lewis Carroll", Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD.

A physician reveals how right-wing backlash policies have mortal consequences - even for the white voters they promise to help.

In How to End the Autism Epidemic, Generation Rescue’s cofounder J.B. Handley offers a compelling, science-based explanation of what’s causing the autism epidemic, the lies that enable its perpetuation, and the steps we must take as parents and as a society in order to end it.

Challenging both the idea of the addict's "broken brain" and the notion of a simple "addictive personality", Unbroken Brain offers a radical and groundbreaking new perspective, arguing that addiction is a learning disorder, and shows how seeing the condition this way can untangle our current debates over treatment, prevention, and policy.

In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Every day, 1,100 adults and children are added to the government disability rolls because they have become newly disabled by mental illness, with this epidemic spreading most rapidly among our nations children. What is going on?

From a renowned behavioral neuroscientist and recovering addict, a rare pause-resisting work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after 25 years as a neuroscientist, she shares what she and other scientists have learned about addiction.

The War on Cancer was run by leaders of industries that made cancer-causing products and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies, a legacy that persists to this day.

A pioneering neuroscientist shares his story of growing up in one of Miami's toughest neighborhoods and how it led him to his groundbreaking work in drug addiction. As a youth, Carl Hart didn't realize the value of school; he studied just enough to stay on the basketball team. At the same time, he was immersed in street life. Today he is a cutting-edge neuroscientist - Columbia University's first tenured African American professor in the sciences.

Medicine is broken. We like to imagine that it's based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry.

Author Ben Goldacre exposes the epidemic of pseudoscience and gives listeners the tools they need to distinguish good science from nonsense.

Past antidrug campaigns actually encouraged drug use. A few years ago, America stopped dropping acid altogether. The meth epidemic peaked a long, long time ago. NAFTA opened the border and created a bonanza for cocaine and meth traffickers just as President Clinton knew it would. President Reagan may have inadvertently caused the crack epidemic. Kids today are doing fewer illegal drugs than kids from any time in the recent past, and for a surprising reason.

Martin A. Lee traces the dramatic social history of marijuana, from its origins to its emergence in the 1960s as a defining force in a culture war that has never ceased. Lee describes how the illicit marijuana subculture overcame government opposition and morphed into a dynamic, multibillion-dollar industry. Colorful, illuminating, and at times irreverent, this is a fascinating listen for recreational users and patients, students and doctors, musicians and accountants, Baby Boomers and their kids, and anyone who has ever wondered about the secret life of this ubiquitous herb.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

Challenging both the idea of the addict's "broken brain" and the notion of a simple "addictive personality", Unbroken Brain offers a radical and groundbreaking new perspective, arguing that addiction is a learning disorder, and shows how seeing the condition this way can untangle our current debates over treatment, prevention, and policy.

Addiction is a preventable, treatable disease, not a moral failing. As with other illnesses, the approaches most likely to work are based on science - not on faith, tradition, contrition, or wishful thinking. These facts are the foundation of Clean, a myth-shattering look at drug abuse by the author of Beautiful Boy. Based on the latest research in psychology, neuroscience, and medicine, Clean is a leap beyond the traditional approaches to prevention and treatment of addiction.

In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Every day, 1,100 adults and children are added to the government disability rolls because they have become newly disabled by mental illness, with this epidemic spreading most rapidly among our nations children. What is going on?

In The Sober Truth, acclaimed addiction specialist Dr. Lance Dodes exposes the deeply flawed science that the 12-step industry has used to support its programs. Dr. Dodes analyzes dozens of studies to reveal a startling pattern of errors, misjudgments, and biases. He also pores over the research to highlight the best peer-reviewed studies available and discovers that they reach a grim consensus on the program's overall success.

A pioneering neuroscientist shares his story of growing up in one of Miami's toughest neighborhoods and how it led him to his groundbreaking work in drug addiction. As a youth, Carl Hart didn't realize the value of school; he studied just enough to stay on the basketball team. At the same time, he was immersed in street life. Today he is a cutting-edge neuroscientist - Columbia University's first tenured African American professor in the sciences.

The War on Cancer was run by leaders of industries that made cancer-causing products and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies, a legacy that persists to this day.

Five years in the making, this brilliant, in-depth investigative reporting on the history, politics, and science of alcoholism will show how AA became our nation's de facto treatment policy, even as evidence for more effective remedies accumulated. US of AA is a character-driven, beautifully written exposé, full of secrecy, irony, liquor industry money, the shrillest of scare tactics and, at its center, a grand deception. US of AA shines a much-needed spotlight on the addiction treatment industry. It will forever change the way we think about the entire enterprise.

Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time - the groundbreaking program to answer the most essential question for humanity: How do we live and die? - and the visionary mastermind behind it.

The Panic Virus is a gripping scientific detective story about how grassroots radicals, snake-oil salesmen, and cynical journalists have perpetrated the biggest health-scare hoax of all time. It explores what happens when the media treats all viewpoints as equally valid, regardless of facts, from parents who are convinced that vaccines caused their children's autism to right-wing radicals who believe that climate change is a myth

From terror attacks to the War on Terror, bursting real-estate bubbles to crystal meth epidemics, sexual predators to poisonous toys from China, our list of fears seems to be exploding. And yet, we are the safest and healthiest humans in history. Irrational fear is running amok, and often with tragic results. In the months after 9/11, when people decided to drive instead of fly - believing they were avoiding risk - road deaths rose by 1,595. Those lives were lost to fear.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Drug overdoses are now the leading cause of death for Americans un­der the age of 50, claiming more lives than the AIDS epidemic did at its peak. Opioid abuse accounts for two-thirds of these overdoses, with over 100 Americans dying from opioid overdoses every day. Now Overcoming Opioid Addiction provides a comprehensive medical guide for opioid use disorder (OUD) sufferers, their loved ones, clinicians, and other professionals. Here is expertly presented, urgently needed in­formation and guidance