Three middle-aged women who have seen their carefully crafted lives take a precipitous financial plunge, forge an unlikely friendship while getting paid to take part in a clinical trial for a new menopause drug. The trio spends a month sequestered at a pharmaceutical testing facility that has all the charm of a nail salon inside a Walmart, and bond over their anger and disbelief that their only hope for some quick cash is leveraging the remaining estrogen they have lurking in their ovaries.

High-powered businesswoman Lana Rubicon has a lot to be proud of: her keen intelligence, impeccable taste, and the L.A. real estate empire she’s built. But when she finds herself trapped 300 miles north of the city, convalescing in a sleepy coastal town with her adult daughter Beth and teenage granddaughter Jack, Lana is stuck counting otters instead of square footage—and hoping that boredom won’t kill her before the cancer does.

Jill and Derick knew a normal life wasn’t possible for them. As a star on the popular TLC reality show 19 Kids and Counting, Jill grew up in front of viewers who were fascinated by her family’s way of life. She was the responsible, second daughter of Jim Bob and Michelle’s nineteen kids; always with a baby on her hip and happy to wear the modest ankle-length dresses with throat-high necklines.

When Holly White's fiancé cancels their Christmas Eve wedding with less than two weeks to go, Holly heads home with a broken heart. Lucky for her, home in historic Mistletoe, Maine is magical during Christmastime - exactly what the doctor prescribed. Except her plan to drown her troubles in peppermints and snickerdoodles is upended when local grouch and president of the Mistletoe Historical Society, Margaret Fenwick, is bludgeoned and left in the sleigh display at Reindeer Games, Holly's family tree farm.

At age 26 Agatha Raisin has already come a long way. She has clawed her way up since leaving the Birmingham slum where she was born. She's lost her Birmingham accent, run away from her drunken husband, and found a job at a public relations office as a secretary. Then her boss asks Agatha to go to the home of Sir Bryce Teller to tell him that he is soon to be arrested for the murder of his wife and that the agency no longer wants to represent him.

The megatalented creator of Grey's Anatomy and Scandal and executive producer of How to Get Away with Murder chronicles how saying yes for one year changed her life - and how it can change yours, too.

Michele's lack of focus in life hasn't bothered her, until the day she finds herself with mounting credit card debt, unable to afford her rent, and without a job. While her meddling family questions how she can end up in this predicament, at the age of 29, and single to boot, Michele doesn't want to admit the truth. All she wants to do is sew. Faced with the prospect of moving back into her parents' house, Michele throws a Hail Mary pass and applies for a TV design contest, Made for Me.

To the untrained eye, Cleopatra Gallier appears to lead a charmed life in Honolulu's paradise. She is impossibly beautiful, clever, wealthy and...trained to kill. When she enters into a love affair with the much younger, irresistibly handsome rogue, Jake Regan, she finds herself colliding with an intricate terrorist plot. Her secret past, like Hawaii's smoldering volcano, is ready to erupt. In the four days leading up to Christmas, two stunning betrayals and a terrorist attack threaten to reduce her and the island she loves to ashes.

Overworked and underappreciated, single mom Amy Byler needs a break. So when the guilt-ridden husband who abandoned her shows up and offers to take care of their kids for the summer, she accepts his offer and escapes rural Pennsylvania for New York City. Usually grounded and mild mannered, Amy finally lets her hair down in the city that never sleeps. She discovers a life filled with culture, sophistication, and - with a little encouragement from her friends - a few blind dates.

Jude and Lauren don't have much in common, but maybe that's why they've been best friends since the third grade. Through ups and downs, they've been by each other's sides. But now? They’re broke, single, and do the only thing that makes sense - move in together, just like they talked about when they were teenagers. Except when they were younger, the plan didn't include a five-year-old daughter and more baggage than their new townhouse can hold.

My name is Calliope and "I bone for a living." Kidding. I am studying to be a paleontologist though. It's the only thing I've ever wanted to be, and I have finally landed the perfect museum internship to make all of my dino-loving dreams come true. Trouble is, everyone wants me to be a gentle, loving sort of creature, but I'm more of the T-Rex type by nature - the kind who is determined to stomp and tear her way through any obstacle in order to get what she wants.

Natalie is a Bloomingdale's salesgirl mooning over her lawyer ex-boyfriend, who's engaged to someone else after just two months. Felicia has been quietly in love with her boss for 17 years and has one night to finally make the feeling mutual. Andie is a private detective who specializes in gathering evidence on cheating husbands - a skill she unfortunately learned from her own life - and lands a case that may restore her faith in true love.

When Georgie discovers that her fiancé has been cheating on her, only a few days before her cousin’s wedding, her whole world explodes. Facing a romantic trip to Vegas alone, she decides to go out and have some fun…but Georgie never expected to wake up wed! And even worse, she can’t remember who to. So when gorgeous Jack reveals himself as her husband, she can’t believe her luck – he’ll act as the perfect wedding date!

Best friends, Casey and Rachel couldn't lead more different lives. While workaholic Casey rubs elbows with celebrities daily as the host of Gossip TV and comes home nightly to an empty apartment, stay-at-home mom Rachel juggles a baby, two teenagers, and a husband who barely seems the man she fell in love with two decades before. After an argument at their 20th high school reunion, Casey and Rachel throw back shots to get the night back on track. Instead, they get a life-changing hangover.

Jen Dixon is not your typical Kansas City kindergarten class mom - or mom in general. Jen already has two college-age daughters by two different (probably) musicians, and it's her second time around the class mom block with five-year-old Max - this time with a husband and father by her side. Though her best friend and PTA president sees her as the "wisest" candidate for the job (or oldest), not all of the other parents agree.

After the killing of a prominent mob lawyer, NYPD homicide detectives Jacob Jackson and Caitlin Grimes start receive chilling, written “rules” for how to commit the perfect murder. "Rule number one for the perfect murder: Evidence is your enemy. Leave none behind." Jackson (Reid Scott) and Grimes (Cobie Smulders) race to find the killer, setting them on a collision course with the city’s crime underbelly, and a perpetrator who seems happy to toy with them. “Rule number two. No crimes of passion. The perfect murder is always business, never pleasure.”

Kidnappers grabbed Jenna in broad daylight, right in front of her children and their horrified classmates. Her family was issued an insane ransom demand: $25 million in cash and jewels, payable by the end of the school day, otherwise they’ll never see her again. As Jenna’s mother scrambles to gather the money, detectives Mo Butler and George Ortega follow the trail of the kidnappers, which will lead them through a sordid landscape of jealous lovers, broken dreamers, and twisted schemers. But every second counts, and there’s one thing Jenna Wade doesn’t have: very much time.

When Heather McKinley dreamed of becoming a doctor, she imagined curing sick kids and sporting pink stethoscopes. She never anticipated the sleepless nights, grueling exams, and endless labs. And she certainly never knew that her medical school earned the nickname Dead Med thanks to the tragic history of students overdosing on illegal drugs. But Heather would never consider doing anything like that. That is, until her longtime boyfriend dumps her, she finds herself failing anatomy, and her world starts to crumble.

Lowen Ashleigh is a struggling writer on the brink of financial ruin when she accepts the job offer of a lifetime. Jeremy Crawford, husband of best-selling author Verity Crawford, has hired Lowen to complete the remaining books in a successful series his injured wife is unable to finish. Lowen arrives at the Crawford home, ready to sort through years of Verity's notes and outlines, hoping to find enough material to get her started. What Lowen doesn't expect to uncover in the chaotic office is an unfinished autobiography Verity never intended for anyone to read.

Cassie thinks she has met the perfect man. Joel is sweet, handsome, romantic, and best of all, he’s crazy about Cassie. She thinks she’s found the guy she’ll spend the rest of her life with. Have children with. Grow old with. Yes, she knows about his perfect ex-girlfriend, Francesca. The beautiful, brilliant chef, beloved by all his friends. But she thinks Francesca is out of the picture. She thinks Francesca is gone for good. Think again, Cassie.

Jenny sits in the same seat on the same train every week, seeing familiar faces come and go. Until a chance encounter shatters her world. Sixteen years ago, Jenny survived a traumatic ordeal that left her best friend, Susie, missing and presumed dead. The world has its theories about what happened to Susie Patterson, and one of those theories points the finger at Jenny. Now she lives a quiet life, volunteering at a crisis helpline while trying to deal with her own anxiety and the true crime fans obsessed with finding her missing friend.

Jazz Bashara is a criminal. Well, sort of. Life on Artemis, the first and only city on the moon, is tough if you're not a rich tourist or an eccentric billionaire. So smuggling in the occasional harmless bit of contraband barely counts, right? Not when you've got debts to pay and your job as a porter barely covers the rent. Everything changes when Jazz sees the chance to commit the perfect crime, with a reward too lucrative to turn down.

They were madly in love. The perfect couple. That was the story everyone in South River believed...until Gin Talcott and Adam Archer are found shot in their bed. Adam is dead at the scene. Gin is fighting for her life. Detectives Greta Jessup and Finn Pate are assigned to the case. Greta has a long history with Gin’s first husband, Eddie, and is determined to protect his 18-year-old twins. Piper discovered the bodies. Daniel is missing—and so is Adam’s gun.

Sloan will go through hell and back for those she loves. And she does so, every single day. Caught up with the alluring Asa Jackson, a notorious drug trafficker, Sloan has finally found a lifeline to cling to, even if it’s meant compromising her morals. She was in dire straits trying to pay for her brother’s care until she met Asa. But as Sloan became emotionally and economically reliant on him, he in turn developed a disturbing obsession with her—one that becomes increasingly dangerous every day.

Tess Strebel can’t recognize her own face. She can’t recognize her home. Her bedroom is unfamiliar. And she can’t remember the handsome stranger lying next to her in bed. A stranger who claims he’s her husband. Tess reads a letter in her own handwriting, composed during a rare lucid day, explaining her life as it now exists: she was in a terrible car accident one year ago. Every morning, she wakes up unable to remember most of the last decade. Including her own wedding.