Courtney Gray's tranquil family vacation is shattered when she hears a blood-curdling scream from the lakeside cottage next door. There she finds the lifeless bodies of her brother and sister-in-law. Her teenage niece Reese is nowhere to be found, while her nephew Wyatt lies asleep upstairs, unharmed.

Quinn Alexander has committed an unthinkable crime. To avoid spending her life in prison, Quinn makes a run for it. She leaves behind her home, her job, and her family. She grabs her passport and heads for the northern border before the police can discover what she's done. But when an unexpected snowstorm forces her off the road, Quinn must take refuge at the broken-down, isolated Baxter Motel. The handsome and kindly owner, Nick Baxter, is only too happy to offer her a cheap room for the night. Unfortunately, the Baxter Motel isn't the quiet, safe haven it seemed to be.

When New York architect Tate Donovan arrives in Cape Cod to design his best friend’s summer home, he is hoping to make a fresh start. Recently discharged from an upscale psychiatric facility where he was treated for acute depression, he is still wrestling with the pain of losing his beloved sister. Sylvia’s deathbed revelation—that she can see spirits who are still tethered to the living world, a gift that runs in their family—sits uneasily with Tate, who struggles to believe in more than what reason can explain.

Restauranteur Paddy Swann was the life of the party until the day a man pushed him in the path of an oncoming train, leaving his twenty-something daughter Ash and wife Nina devastated. Shortly after Paddy’s funeral, the two women receive a surprise in the mail: a note and package from Nick Radcliffe, an old friend of Paddy’s, and a nondescript lighter that once belonged to him decades ago. This unexpected gift draws Nick and Nina closer together—much to Ash’s dismay.

In the glow of their children’s exciting first year of college at a small private school in Northern California, five families plan on a night of dinner and cocktails for the opening festivities of Parents Weekend. As the parents stay out way past their bedtimes, their kids—five residents of Campisi Hall—never show up at dinner.