A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

We are living in a golden age in astronomy and in the search for life the universe. Over the last few decades, space exploration has shown that not only are there habitable environments within our solar system, but there are millions of exoplanets within our galaxy that could support life. We are on the cusp of breakthroughs that will revolutionize our understanding of our place in the cosmos in. In The Secret Life of the Universe, astrobiologist and the director of the Carl Sagan Center at the SETI Institute Nathalie A. Cabrol takes us to the frontiers of the search for life.

At its simplest, Bayes’s theorem describes the probability of an event, based on prior knowledge of conditions that might be related to the event. But in Everything Is Predictable, Tom Chivers lays out how it affects every aspect of our lives. He explains why highly accurate screening tests can lead to false positives and how a failure to account for it in court has put innocent people in jail. A cornerstone of rational thought, many argue that Bayes’s theorem is a description of almost everything. But who was the man who lent his name to this theorem?

Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.

In How the World Made the West, Josephine Quinn poses perhaps the most significant challenge ever to the “civilizational thinking” regarding the origins of Western culture—that is, the idea that civilizations arose separately and distinctly from one another. Rather, she locates the roots of the modern West in everything from the law codes of Babylon, Assyrian irrigation, and the Phoenician art of sail to Indian literature, Arabic scholarship, and the metalworking riders of the Steppe, to name just a few examples.

Trigonometry is perhaps the most essential concept humans have ever devised. The simple yet versatile triangle allows us to record music, map the world, launch rockets into space, and be slightly less bad at pool. Triangles underpin our day-to-day lives and civilization as we know it. In Love Triangle, Matt Parker argues we should all show a lot more love for triangles, along with all the useful trigonometry and geometry they enable.

In the bestselling The Signal and the Noise, Nate Silver showed how forecasting would define the age of Big Data. Now, in this timely and riveting new book, Silver investigates "The River," or those whose mastery of risk allows them to shape—and dominate—so much of modern life. These professional risk takers—poker players and hedge fund managers, crypto true-believers and blue-chip art collectors—can teach us much about navigating the uncertainty of the 21st century.

In this vivid and alluring history, medievalist Anthony Bale invites listeners on an odyssey across the medieval world. Journeying alongside scholars, spies, and saints, from Western Europe to the Far East, the Antipodes and the ends of the earth, Bale provides indispensable information on the exchange rate between Bohemian ducats and Venetian groats, medieval cures for seasickness, and how to avoid extortionist tour guides and singing sirens.

We tend to think of the Middle Ages as a dark, backward, and unchanging time characterized by violence, ignorance, and superstition. By contrast, we believe progress arose from science and technological innovation, and that inventions of recent centuries created the modern world. We couldn't be more wrong.

Populist rage, ideological fracture, economic and technological shocks, geopolitical dangers, and an international system studded with catastrophic risk—the early decades of the 21st century may be one of the most revolutionary periods in modern history. But they are not the first. Humans have lived, and thrived, through more than one great realignment. What makes an age a revolutionary one? And how do they end?

For the last 100,000 years, we Sapiens have accumulated enormous power. But despite all our discoveries, inventions, and conquests, we now find ourselves in an existential crisis. The world is on the verge of ecological collapse. Misinformation abounds. And we are rushing headlong into the age of AI—a new information network that threatens to annihilate us. For all that we have accomplished, why are we so self-destructive? Nexus looks through the long lens of human history to consider how the flow of information has shaped us, and our world.

How a band of antislavery leaders recovered the radical philosophical inspirations of the first American Revolution to defeat the slaveholders' oligarchy in the Civil War.

The knowledge of death is so terrifying that we live most of our lives in denial of it. One of the most difficult moments of childhood must be when each of us first realizes that not only we but all our loved ones will die—and there is nothing we can do about it. Or at least, there hasn’t been. Today, we are living through a revolution in biology. Giant strides are being made in understanding why we age—and why some species live longer than others. Could we eventually cheat disease and death and live for a very long time, possibly many times our current lifespan?

In April 1942, the Imperial Japanese Army steamrolled through Burma, capturing the only ground route from India to China. Supplies to this critical zone would now have to come from India by air—meaning across the Himalayas, on the most hazardous air route in the world. SKIES OF THUNDER is a story of an epic human endeavor, in which Allied troops faced the monumental challenge of operating from airfields hacked from the jungle, and took on “the Hump,” the fearsome mountain barrier that defined the air route.

A vast and largely unseen transformation of how war is fought as profound as the invention of gunpowder or advent of the nuclear age is occurring. Flying cars that can land like helicopters, artificial intelligence-powered drones that can fly into buildings and map their interiors, microsatellites that can see through clouds and monitor rogue missile sites—all these and more are becoming part of America’s DIU-fast-tracked arsenal. Until recently, the Pentagon was known for its uncomfortable relationship with Silicon Valley and for slow-moving processes that acted as a brake on innovation.

Richard Dawkins' brilliant reformulation of the theory of natural selection has the rare distinction of having provoked as much excitement and interest outside the scientific community as within it. His theories have helped change the whole nature of the study of social biology, and have forced thousands to rethink their beliefs about life.

Astrophysicist Neil deGrasse Tyson has attracted one of the world’s largest online followings with his fascinating, widely accessible insights into science and our universe. Now, Tyson invites us to go behind the scenes of his public fame by unveiling his candid correspondence with people across the globe who have sought him out in search of answers. In this hand-picked collection of 100 letters, Tyson draws upon cosmic perspectives to address a vast array of questions about science, faith, philosophy, life, and of course, Pluto.

How the Earth Works takes you on an astonishing journey through time and space. In 48 lectures, you will look at what went into making our planet - from the big bang, to the formation of the solar system, to the subsequent evolution of Earth.

Hilarious, fascinating, and a roller coaster of dizzying, historical what-ifs, Napoleon's Hemorrhoids is a potpourri for serious historians and casual history buffs. In one of Phil Mason's many revelations, you'll learn that Communist jets were two minutes away from opening fire on American planes during the Cuban missile crisis, when they had to turn back as they were running out of fuel. You'll discover that before the Battle of Waterloo, Napoleon's painful hemorrhoids prevented him from mounting his horse to survey the battlefield.

Chemistry and Our Universe: How It All Works is your in-depth introduction to this vital field, taught through 60 engaging half-hour lectures that are suitable for any background or none at all. Covering a year’s worth of introductory general chemistry at the college level, plus intriguing topics that are rarely discussed in the classroom, this amazingly comprehensive course requires nothing more advanced than high-school math. Your guide is Professor Ron B. Davis, Jr., a research chemist and award-winning teacher at Georgetown University.

Welcome to the Universe is a personal guided tour of the cosmos by three of today's leading astrophysicists. Inspired by the enormously popular introductory astronomy course that Neil deGrasse Tyson, Michael A. Strauss, and J. Richard Gott taught together at Princeton, this book covers it all - from planets, stars, and galaxies to black holes, wormholes, and time travel.

From launchpad explosions to a pernicious cricket infestation to the demanding management style of Musk himself, the rise of SpaceX was beset with challenges and far from inevitable. Find out how the startup beat the odds and flew high enough to outpace their rivals... and where they're going next.

How do today's most successful tech companies - Amazon, Google, Facebook, Netflix, Tesla - design, develop, and deploy the products that have earned the love of literally billions of people around the world? Perhaps surprisingly, they do it very differently from the vast majority of tech companies. In Inspired, technology product management thought leader Marty Cagan provides listeners with a master class in how to structure and staff a vibrant and successful product organization and how to discover and deliver technology products that your customers will love.

In The Butchering Art, the historian Lindsey Fitzharris reveals the shocking world of 19th-century surgery on the eve of profound transformation. She conjures up early operating theaters - no place for the squeamish - and surgeons, working before anesthesia, who were lauded for their speed and brute strength. They were baffled by the persistent infections that kept mortality rates stubbornly high. A young, melancholy Quaker surgeon named Joseph Lister would solve the deadly riddle and change the course of history.

In this illuminating audiobook, Tyson and coauthor James Trefil, a renowned physicist and science popularizer, take on the big questions that humanity has been posing for millennia - How did life begin? What is our place in the universe? Are we alone? - and provide answers based on the most current data, observations, and theories.

We are living in a golden age in astronomy and in the search for life the universe. Over the last few decades, space exploration has shown that not only are there habitable environments within our solar system, but there are millions of exoplanets within our galaxy that could support life. We are on the cusp of breakthroughs that will revolutionize our understanding of our place in the cosmos in. In The Secret Life of the Universe, astrobiologist and the director of the Carl Sagan Center at the SETI Institute Nathalie A. Cabrol takes us to the frontiers of the search for life.

In this visionary book, Leslie Valiant argues that understanding the nature of our own educability is crucial to safeguarding our future. After breaking down how we process information to learn and apply knowledge, and drawing comparisons with other animals and AI systems, he explains why education should be humankind's central preoccupation. Will the unique capability that has been so foundational to our achievements and civilization continue to drive our progress, or will we fall victim to our vulnerabilities?

Money laundering has been around for centuries. For as long as people have been stealing money, there's been an industry ready to wash it. But recent tech innovations have created vastly complex new systems for laundering that threaten to overwhelm authorities, destabilise economies and disrupt societies. Ranging from the flamboyant luxury of Dubai hotels to quiet coastal Ireland, from the UK to Nigeria and from Indonesia to North Korea, Rinsed is a truly global relevatory investigation into the new army of innovative launderers ... and the consequences for all of us.

Bea couldn't be more excited to trade the stifling Stockholm summer heat for vacation on Gotland Island. She’s looking forward to spending quality time with her beloved husband of thirty-two years, Niklas, and their two moody teenage daughters, and recuperating from the stress of daily life in the company of her beloved in-laws. One night shortly before their departure, Bea and Niklas have a seemingly mundane argument over a trivial issue, and Niklas goes out with a friend to blow off steam.

When Mary McLeod Bethune died, tributes in newspapers around the country said the same thing: she should be on the Mount Rushmore of Black American achievement. Indeed, Bethune is the only Black American whose statue stands in the rotunda of the US Capitol, and yet for most, she remains a marble figure from the dim past. Now, seventy years later, Noliwe Rooks turns Bethune from stone to flesh, showing her to have been a visionary leader with lessons to still teach us as we continue on our journey toward a freer and more just nation.

We are living through a revolution in machine learning-powered AI that shows no signs of slowing down. This technology is based on relatively simple mathematical ideas, some of which go back centuries, including linear algebra and calculus, the stuff of seventeenth- and eighteenth-century mathematics. It took the birth and advancement of computer science and the kindling of 1990s computer chips designed for video games to ignite the explosion of AI that we see today. In this enlightening book, Anil Ananthaswamy explains the fundamental math behind machine learning.

Meet the Lazarus Group, a shadowy cabal of hackers accused of working on behalf of the North Korean state. It's claimed that they form one of the most dangerous criminal enterprises on the planet, having stolen more than $1bn in an international crime spree. Their targets allegedly include central banks, Hollywood film studios and even the British National Health Service. North Korea denies the allegations, saying the accusations are American attempts to tarnish its image.

At its simplest, Bayes’s theorem describes the probability of an event, based on prior knowledge of conditions that might be related to the event. But in Everything Is Predictable, Tom Chivers lays out how it affects every aspect of our lives. He explains why highly accurate screening tests can lead to false positives and how a failure to account for it in court has put innocent people in jail. A cornerstone of rational thought, many argue that Bayes’s theorem is a description of almost everything. But who was the man who lent his name to this theorem?

If the history of the Earth were compressed down to a year, our species would arise in the last thirty minutes or so of the final hour. But life itself is not such a late arrival: It has existed on Earth for something like 3.7 billion years—most of our planet’s history and over a quarter of the age of the universe (as far as we can tell). What have these organisms—bacteria, animals, plants, and the rest—done in all this time? In Living on Earth, the philosopher Peter Godfrey-Smith proposes a new way of understanding how the actions of living beings have shaped our planet.

How did we become a world where facts—shared truths—have lost their power to hold us together as a community, as a country, globally? How have we allowed the proliferation of alternative facts, hoaxes, even conspiracy theories, to destroy our trust in institutions, leaders, and legitimate experts? Best-selling journalist Steven Brill documents the forces and people, from Silicon Valley to Moscow to Washington, that have created and exploited this world of chaos and division—and offers practical solutions for what we can do about it.

The Coin’s narrator is a wealthy Palestinian woman with impeccable style and meticulous hygiene. And yet the ideal self, the ideal life, remains just out of reach: her inheritance is inaccessible, her homeland exists only in her memory, and her attempt to thrive in America seems doomed from the start. In New York, she strives to put down roots. She teaches at a school for underprivileged boys, where her eccentric methods cross boundaries. She befriends a homeless swindler, and the two participate in an intercontinental scheme reselling Birkin bags.

In The Extinction of Experience, Christine Rosen investigates the cultural and emotional shifts that accompany our embrace of technology. In warm, philosophical prose, Rosen reveals key human experiences at risk of going extinct, including face-to-face communication, sense of place, authentic emotion, and even boredom. Considering cultural trends, like TikTok challenges and mukbang, and politically unsettling phenomena, like sociometric trackers and online conspiracy culture, Rosen exposes an unprecedented shift in the human condition, one that habituates us to alienation and control.

A vast and largely unseen transformation of how war is fought as profound as the invention of gunpowder or advent of the nuclear age is occurring. Flying cars that can land like helicopters, artificial intelligence-powered drones that can fly into buildings and map their interiors, microsatellites that can see through clouds and monitor rogue missile sites—all these and more are becoming part of America’s DIU-fast-tracked arsenal. Until recently, the Pentagon was known for its uncomfortable relationship with Silicon Valley and for slow-moving processes that acted as a brake on innovation.

In the bestselling The Signal and the Noise, Nate Silver showed how forecasting would define the age of Big Data. Now, in this timely and riveting new book, Silver investigates "The River," or those whose mastery of risk allows them to shape—and dominate—so much of modern life. These professional risk takers—poker players and hedge fund managers, crypto true-believers and blue-chip art collectors—can teach us much about navigating the uncertainty of the 21st century.

Many books have been written about J. Doyne Farmer and his work, but this is the first in his own words. It presents a manifesto for how to do economics better. In this tale of science and ideas, Farmer fuses his profound knowledge and expertise with stories from his life to explain how we can bring a scientific revolution to bear on the economic conundrums facing society.