In the summer of 2015, Ross Douthat was moving his family, with two young daughters and a pregnant wife, from Washington, DC, to a sprawling farmhouse in a picturesque Connecticut town when he acquired a mysterious and devastating sickness. It left him sleepless, crippled, wracked with pain - a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which, according to CDC definitions, does not actually exist.

Novelist Porochista Khakpour's family moved to Los Angeles after fleeing the Iranian Revolution, giving up their successes only to be greeted by an alienating culture. Growing up as an immigrant in America means that one has to make one's way through a confusing tangle of conflicting cultures and expectations. And Porochista is pulled between the glitzy culture of Tehrangeles, an enclave of wealthy Iranians and Persians in LA, her own family's modest life and culture, and becoming an assimilated American.

A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier.

The incredible true story of the entrepreneur turned conservationist - the founder of the iconic company The North Face who used his fortune to protect more than 25 million acres of land from development and exploitation and “foster peace between people and wild nature”.

I Have Been Buried Under Years of Dust is a remarkable memoir by a mother and her autistic daughter who’d long been unable to communicate - until a miraculous breakthrough revealed a young woman with a rich and creative interior life, a poet, who’d been trapped inside for more than two decades.

An intimate, moving book written with the immediacy and directness of one who still struggles with the effects of mental and chronic illness, The Collected Schizophrenias cuts right to the core. Schizophrenia is not a single unifying diagnosis, and Esmé Weijun Wang writes not just to her fellow members of the “collected schizophrenias” but to those who wish to understand it as well.

At the University of Wisconsin, Dr. Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.

Sy Montgomery's popular 2011 Orion magazine piece, "Deep Intellect", about her friendship with a sensitive, sweet-natured octopus named Athena and the grief she felt at her death, went viral, indicating the widespread fascination with these mysterious, almost alien-like creatures. Since then Sy has practiced true immersion journalism, from New England aquarium tanks to the reefs of French Polynesia and the Gulf of Mexico, pursuing these wild, solitary shape-shifters.

Welcome to 97-hour weeks. Welcome to life and death decisions. Welcome to a constant tsunami of bodily fluids. Welcome to earning less than the hospital parking meter. Wave goodbye to your friends and relationships. Welcome to the life of a first-year doctor. Scribbled in secret after endless days, sleepless nights, and missed weekends, comedian and former medical resident Adam Kay’s This Is Going to Hurt provides a no-holds-barred account of his time on the front lines of medicine.

Poisoner, despot, necromancer - the dark legend of Catherine de Medici is centuries old. In this critically hailed biography, Leonie Frieda reclaims the story of this unjustly maligned queen to reveal a skilled ruler battling extraordinary political and personal odds - from a troubled childhood in Florence to her marriage to Henry, son of King Francis I of France; from her transformation of French culture to her fight to protect her throne and her sons' birthright. Based on thousands of private letters, it is a remarkable account of one of the most influential women to wear a crown.

Ally was at a breaking point when she woke up in a psych ward at the age of 18. She couldn't put a sentence together, let alone take a shower, eat a meal, or pick up a phone. What had gone wrong? In recent years, she had produced a feature film, a popular reality show for a major network, and had acted in an off-Broadway play. But now Ally was pushed to a psychotic break after struggling since she was seven years old with physical symptoms that no doctor could explain - everything from joint pain to night sweats, memory loss, nausea, and brain fog.

One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose of­fice she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but.

In this fascinating narrative, therapist Catherine Gildiner presents five of what she calls her most heroic and memorable patients. Among them: A successful, first-generation Chinese immigrant musician suffering sexual dysfunction; a young woman whose father abandoned her at age nine with her younger siblings in an isolated cottage in the depth of winter; and a glamorous workaholic whose narcissistic, negligent mother greeted her each morning of her childhood with "Good morning, Monster". Each patient presents a mystery, one that will only be unpacked over years.

The science of emotion is in the midst of a revolution on par with the discovery of relativity in physics and natural selection in biology. Leading the charge is psychologist and neuroscientist Lisa Feldman Barrett, whose research overturns the long-standing belief that emotions are automatic, universal, and hardwired in different brain regions. Instead, Barrett shows, we construct each instance of emotion through a unique interplay of brain, body, and culture.

Whether you’re simply browsing, talking to friends, or trying to stay focused in an important meeting, you can’t seem to manage to hang on to your attention. No matter how hard you try, you’re somewhere else. The consequence is that you miss out on 50 percent of your life - including the most important moments.

Professor of psychiatry Elyn R. Saks writes about her struggle with schizophrenia in this unflinching account of her mental illness. In The Center Cannot Hold, Saks draws readers into a nightmare world of medications, a misguided health-care system, and social stigmas. But she would not be defeated. With a strength and force of will that most can only imagine, Saks reclaimed her life and went on to achieve great success.

His name was Joshua Silver. He was 23 years old, educated, and had an impressive vocabulary. The NYPD had found Joshua Silver naked in Times Square, barking like a dog. It was just another night for Julie Holland, the attending doctor in the world famous Bellevue Hospital's psychiatric emergency room.

True stories are more bizarre than any fiction, and Dr. Gary Small knows this best. After 30 distinguished years of psychiatry and groundbreaking research on the human brain, Dr. Small has seen it all - now he is ready to open his office doors for the first time and tell all about the most mysterious, intriguing, and bizarre patients of his career. The Naked Lady Who Stood on Her Head is a spellbinding record of the doctor's most bewildering cases.

When Edward M. Hallowell was 11, a voice out of nowhere told him he should become a psychiatrist. A mental health professional of the time would have called this psychosis. But young Edward (Ned) took it in stride, despite not quite knowing what "psychiatrist" meant. With a psychotic father, an alcoholic mother, an abusive stepfather, and two so-called learning disabilities of his own, Ned was accustomed to unpredictable behaviour from those around him and to a mind he felt he couldn't always control.

It's a report tempered by hard times. In "Matricide", Daum unflinchingly describes a parent's death and the uncomfortable emotions it provokes; and in "Diary of a Coma" she relates her own journey to the twilight of the mind. But Daum also operates in a comic register. With perfect precision, she reveals the absurdities of the marriage-industrial complex, of the New Age dating market, and of the peculiar habits of the young and digital.

Clare Dunkle seemed to have an ideal life - two beautiful, high-achieving teenage daughters, a loving husband, and a satisfying and successful career as a children's book novelist. But it's when you let down your guard that the ax falls. Just after one daughter successfully conquered her depression, another daughter developed a life-threatening eating disorder.

David Menasche lived for his work as a high school English teacher. His passion inspired his students, and between lessons on Shakespeare and sentence structure, he forged a unique bond with his kids, buoying them through personal struggles while sharing valuable life lessons.

This Close to Happy is the rare, vividly personal account of what it feels like to suffer from clinical depression, written from a woman's perspective and informed by an acute understanding of the implications of this disease over a lifetime. Taking off from essays on depression she has written for The New Yorker and The New York Times Magazine, Daphne Merkin casts her eye back to her beginnings to try to sort out the root causes of her affliction.

Lauren Marks was 27 when an aneurysm ruptured in her brain and left her fighting for her life. She woke up in a hospital soon after with serious deficiencies to her reading, speaking, and writing abilities, and an unfamiliar diagnosis: aphasia. This would be shocking news for anyone, but Lauren was a voracious reader, an actress, director, dramaturg, and pursuing her PhD. At any other period of her life, this diagnosis would have been a devastating blow. But she woke up...different.

Leaving a life marked by crippling setbacks and his father's doubt, in 1967 a 20-something doctor from India arrived in America with only five dollars and the desire to claim his American dream. Faced with an entirely new culture, racism, and the lasting effects of disabling childhood injuries, through hard work and perseverance he overcame all odds. Now having performed over 15,000 open-heart surgeries, more than nearly every surgeon in history, Dr. Singh reflects on his most memorable patients and his incredible personal life.

When Amy B. Scher was struck with undiagnosed late-stage, chronic Lyme disease, the best physicians in America labeled her condition incurable and potentially terminal. Deteriorating rapidly, she went on a search to save her own life - from the top experts in Los Angeles and the world-renowned Mayo Clinic in Minneapolis to a state-of-the-art hospital in Chicago. After exhausting all of her options in the US, she discovered a possible cure - but it was highly experimental, available only in India, and had as much of a probability of killing her as it did of curing her.

One of the funniest and most poignant books ever written about a mental illness, Agorafabulous! is a hilarious, raw, and unforgettable account of how a terrified young woman, literally trapped by her own imagination, evolved into a (relatively) high-functioning professional smartass. Down to earth and seriously funny, Benincasa's no-holds-barred revelations offer listeners the politically incorrect hilarity they heartily crave, yet is so often missing from your typical, weepy, and redemptive personal memoir.

What could possibly be “lucky” about addiction? Absolutely nothing, thought Laura McKowen when drinking brought her to her knees. As she puts it, she “kicked and screamed . . . wishing for something - anything - else” to be her issue. The people who got to drink normally, she thought, were so damn lucky. But in the midst of early sobriety, when no longer able to anesthetize her pain and anxiety, she realized that she was actually the lucky one. Lucky to feel her feelings, live honestly, really be with her daughter, change her legacy.

Emma Forrest, a British journalist, was just 22 and living the fast life in New York City when she realized that her quirks had gone beyond eccentricity. In a cycle of loneliness, damaging relationships, and destructive behavior, she found herself in the chair of a slim, balding, and effortlessly optimistic psychiatrist--a man whose wisdom and humanity would wrench her from the dangerous tide after she tried to end her life.

Journalist Debbie Nathan reveals the true story behind the famous case of Sybil, the woman with sixteen different personalities.

When 24-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she’d gotten there. Days earlier, she had been on the threshold of a new, adult life: At the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?

In her harrowing, defiant, and unforgettable memoir, Sarah Ramey recounts the decade-long saga of how a seemingly minor illness in her senior year of college turned into a prolonged and elusive condition that destroyed her health but that doctors couldn't diagnose or treat. Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological. The Lady's Handbook for Her Mysterious Illness is a memoir with a mission: to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions.

In the summer of 2015, Ross Douthat was moving his family, with two young daughters and a pregnant wife, from Washington, DC, to a sprawling farmhouse in a picturesque Connecticut town when he acquired a mysterious and devastating sickness. It left him sleepless, crippled, wracked with pain - a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which, according to CDC definitions, does not actually exist.

Anna was living a normal life. She was ambitious and worked hard; she had just bought an apartment; she was falling in love. But then she started to develop worrying symptoms: her face felt like it was burning whenever she was in front of the computer. Soon this progressed to an intolerance of fluorescent light, then of sunlight itself. The reaction soon spread to her entire body.

A riveting and candid account of a young journalist's awakening to a life of chronic illness, weaving together her personal story with reporting to shed light on how Americans live with long-term diagnoses today.