In the summer of 2015, Ross Douthat was moving his family, with two young daughters and a pregnant wife, from Washington, DC, to a sprawling farmhouse in a picturesque Connecticut town when he acquired a mysterious and devastating sickness. It left him sleepless, crippled, wracked with pain - a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which, according to CDC definitions, does not actually exist.

Novelist Porochista Khakpour's family moved to Los Angeles after fleeing the Iranian Revolution, giving up their successes only to be greeted by an alienating culture. Growing up as an immigrant in America means that one has to make one's way through a confusing tangle of conflicting cultures and expectations. And Porochista is pulled between the glitzy culture of Tehrangeles, an enclave of wealthy Iranians and Persians in LA, her own family's modest life and culture, and becoming an assimilated American.

A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier.

The incredible true story of the entrepreneur turned conservationist - the founder of the iconic company The North Face who used his fortune to protect more than 25 million acres of land from development and exploitation and “foster peace between people and wild nature”.

I Have Been Buried Under Years of Dust is a remarkable memoir by a mother and her autistic daughter who’d long been unable to communicate - until a miraculous breakthrough revealed a young woman with a rich and creative interior life, a poet, who’d been trapped inside for more than two decades.

An intimate, moving book written with the immediacy and directness of one who still struggles with the effects of mental and chronic illness, The Collected Schizophrenias cuts right to the core. Schizophrenia is not a single unifying diagnosis, and Esmé Weijun Wang writes not just to her fellow members of the “collected schizophrenias” but to those who wish to understand it as well.

At the University of Wisconsin, Dr. Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.

Sy Montgomery's popular 2011 Orion magazine piece, "Deep Intellect", about her friendship with a sensitive, sweet-natured octopus named Athena and the grief she felt at her death, went viral, indicating the widespread fascination with these mysterious, almost alien-like creatures. Since then Sy has practiced true immersion journalism, from New England aquarium tanks to the reefs of French Polynesia and the Gulf of Mexico, pursuing these wild, solitary shape-shifters.

Welcome to 97-hour weeks. Welcome to life and death decisions. Welcome to a constant tsunami of bodily fluids. Welcome to earning less than the hospital parking meter. Wave goodbye to your friends and relationships. Welcome to the life of a first-year doctor. Scribbled in secret after endless days, sleepless nights, and missed weekends, comedian and former medical resident Adam Kay’s This Is Going to Hurt provides a no-holds-barred account of his time on the front lines of medicine.

Poisoner, despot, necromancer - the dark legend of Catherine de Medici is centuries old. In this critically hailed biography, Leonie Frieda reclaims the story of this unjustly maligned queen to reveal a skilled ruler battling extraordinary political and personal odds - from a troubled childhood in Florence to her marriage to Henry, son of King Francis I of France; from her transformation of French culture to her fight to protect her throne and her sons' birthright. Based on thousands of private letters, it is a remarkable account of one of the most influential women to wear a crown.

Ally was at a breaking point when she woke up in a psych ward at the age of 18. She couldn't put a sentence together, let alone take a shower, eat a meal, or pick up a phone. What had gone wrong? In recent years, she had produced a feature film, a popular reality show for a major network, and had acted in an off-Broadway play. But now Ally was pushed to a psychotic break after struggling since she was seven years old with physical symptoms that no doctor could explain - everything from joint pain to night sweats, memory loss, nausea, and brain fog.

One day, Lori Gottlieb is a therapist who helps patients in her Los Angeles practice. The next, a crisis causes her world to come crashing down. Enter Wendell, the quirky but seasoned therapist in whose of­fice she suddenly lands. With his balding head, cardigan, and khakis, he seems to have come straight from Therapist Central Casting. Yet he will turn out to be anything but.

In this fascinating narrative, therapist Catherine Gildiner presents five of what she calls her most heroic and memorable patients. Among them: A successful, first-generation Chinese immigrant musician suffering sexual dysfunction; a young woman whose father abandoned her at age nine with her younger siblings in an isolated cottage in the depth of winter; and a glamorous workaholic whose narcissistic, negligent mother greeted her each morning of her childhood with "Good morning, Monster". Each patient presents a mystery, one that will only be unpacked over years.

The science of emotion is in the midst of a revolution on par with the discovery of relativity in physics and natural selection in biology. Leading the charge is psychologist and neuroscientist Lisa Feldman Barrett, whose research overturns the long-standing belief that emotions are automatic, universal, and hardwired in different brain regions. Instead, Barrett shows, we construct each instance of emotion through a unique interplay of brain, body, and culture.

Whether you’re simply browsing, talking to friends, or trying to stay focused in an important meeting, you can’t seem to manage to hang on to your attention. No matter how hard you try, you’re somewhere else. The consequence is that you miss out on 50 percent of your life - including the most important moments.