The Alzheimer Conundrum
Entanglements of Dementia and Aging
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Narrated by:
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Carly Robins
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By:
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Margaret Lock
About this listen
Because of rapidly aging populations, the number of people worldwide experiencing dementia is increasing and the projections are grim. Despite hundreds of millions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer's disease through early detection of presymptomatic biological changes in healthy individuals.
Based on a careful study of the history of Alzheimer's disease and extensive in-depth interviews with clinicians, scientists, epidemiologists, geneticists, and others, Margaret Lock highlights the limitations and the dissent implicated in this approach. She stresses that one major difficulty is the well-documented absence of behavioral signs of Alzheimer's disease in a significant proportion of elderly individuals, even when Alzheimer neuropathology is present in their brains. This incongruity makes it difficult to distinguish between what counts as normal versus pathological and, further, makes it evident that social and biological processes contribute inseparably to aging. Lock argues that basic research must continue, but it should be complemented by a realistic public health approach available everywhere that will be more effective and more humane than one focused almost exclusively on an increasingly frenzied search for a cure.
Download the accompanying reference guide.©2013 Princeton University Press (P)2013 Audible, Inc.Listeners also enjoyed...
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Intriguing
- By L. K. on 04-18-16
By: Joel Gold, and others
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Doing Harm
- By: Maya Dusenbery
- Narrated by: Dara Rosenberg
- Length: 13 hrs and 33 mins
- Unabridged
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Editor of the award-winning site Feministing.com, Maya Dusenbery brings together scientific and sociological research, interviews with experts within and outside the medical establishment, and personal stories from women across the country to provide the first comprehensive, accessible look at how sexism in medicine harms women today.
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One of the most important books ever written
- By Dresden on 03-18-18
By: Maya Dusenbery
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The Book of Why
- The New Science of Cause and Effect
- By: Judea Pearl, Dana Mackenzie
- Narrated by: Mel Foster
- Length: 15 hrs and 14 mins
- Unabridged
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"Correlation does not imply causation". This mantra has been invoked by scientists for decades and has led to a virtual prohibition on causal talk. But today, that taboo is dead. The causal revolution, sparked by Judea Pearl and his colleagues, has cut through a century of confusion and placed causality - the study of cause and effect - on a firm scientific basis.
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Great book! Not a great audiobook.
- By rrwright on 05-30-18
By: Judea Pearl, and others
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Sicker, Fatter, Poorer
- The Urgent Threat of Hormone-Disrupting Chemicals on Our Health and Future . . . and What We Can Do About It
- By: Leonardo Trasande MD MPP
- Narrated by: Leonardo Trasande MD MPP
- Length: 6 hrs and 44 mins
- Unabridged
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Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we’ve turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he reveals what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
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The Must Read Book of 2019 is here early on Audio!
- By Ryan S on 12-21-18
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Drugged: The Science and Culture Behind Psychotropic Drugs
- By: Richard J. Miller
- Narrated by: Roger Clark
- Length: 15 hrs and 42 mins
- Unabridged
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In Drugged, Miller takes listeners on an eye-opening tour of psychotropic drugs, describing the various kinds, how they were discovered and developed, and how they have played multiple roles in virtually every culture. Drugged brims with surprises, revealing the fact that antidepressant drugs evolved from rocket fuel, highlighting the role of hallucinogens in the history of religion, and asking whether Prozac can help depressed cats. Entertaining and authoritative, Drugged is a truly fascinating book.
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Interesting reading but heavy on the biochemistry
- By Scott on 06-28-14
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The Book of Woe
- The DSM and the Unmaking of Psychiatry
- By: Gary Greenberg
- Narrated by: David Drummond
- Length: 14 hrs
- Unabridged
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For more than two years, author and psychotherapist Gary Greenberg has embedded himself in the war that broke out over the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (the DSM) - the American Psychiatric Association's (APA) compendium of mental illnesses and what Greenberg calls "the book of woe". Since its debut in 1952, the book has been frequently revised, and with each revision, the "official" view on which psychological problems constitute mental illness has changed.
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Disappointment
- By NYNM on 06-03-13
By: Gary Greenberg
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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Counterclockwise
- Mindful Health and the Power of Possibility
- By: Ellen J. Langer
- Narrated by: Sandra Burr
- Length: 7 hrs and 10 mins
- Unabridged
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If we could turn back the clock psychologically, could we also turn it back physically? For more than 30 years, award-winning social psychologist Ellen Langer has studied this provocative question, and now has a conclusive answer: opening our minds to what's possible, instead of clinging to accepted notions about what's not, can lead to better health at any age.
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Surprisingly disappointing
- By Stephen on 06-23-09
By: Ellen J. Langer
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p53: The Gene That Cracked the Cancer Code
- By: Sue Armstrong
- Narrated by: Elizabeth Jasicki
- Length: 9 hrs and 55 mins
- Unabridged
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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The Panic Virus
- A True Story of Medicine, Science, and Fear
- By: Seth Mnookin
- Narrated by: Dan John Miller
- Length: 10 hrs and 44 mins
- Unabridged
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The Panic Virus is a gripping scientific detective story about how grassroots radicals, snake-oil salesmen, and cynical journalists have perpetrated the biggest health-scare hoax of all time. It explores what happens when the media treats all viewpoints as equally valid, regardless of facts, from parents who are convinced that vaccines caused their children's autism to right-wing radicals who believe that climate change is a myth
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Incredible thorough journey
- By Rachel Dewald on 03-22-11
By: Seth Mnookin
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Anatomy of an Epidemic
- Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America
- By: Robert Whitaker
- Narrated by: Ken Kliban
- Length: 13 hrs and 57 mins
- Unabridged
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In this astonishing and startling book, award-winning science and history writer Robert Whitaker investigates a medical mystery: Why has the number of disabled mentally ill in the United States tripled over the past two decades? Every day, 1,100 adults and children are added to the government disability rolls because they have become newly disabled by mental illness, with this epidemic spreading most rapidly among our nations children. What is going on?
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The author does not use a fair scientific approach
- By Michael on 08-15-10
By: Robert Whitaker
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The Sober Truth
- Debunking the Bad Science Behind 12-Step Programs and the Rehab Industry
- By: Lance Dodes MD, Zachary Dodes
- Narrated by: Stephen Bel Davies
- Length: 6 hrs and 31 mins
- Unabridged
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In The Sober Truth, acclaimed addiction specialist Dr. Lance Dodes exposes the deeply flawed science that the 12-step industry has used to support its programs. Dr. Dodes analyzes dozens of studies to reveal a startling pattern of errors, misjudgments, and biases. He also pores over the research to highlight the best peer-reviewed studies available and discovers that they reach a grim consensus on the program's overall success.
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A necessary read for those with genuine interest
- By Gregory W Minton on 05-06-19
By: Lance Dodes MD, and others