The Deeper Genome
Why There Is More to the Human Genome than Meets the Eye
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Narrated by:
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John Lee
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By:
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John Parrington
About this listen
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases and understand what makes us unique among animals. But things didn't turn out that way. For a start we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2 percent. So, was the rest of the genome accumulated "junk"? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is, if anything, far more exciting. In this book John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE program, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals, as well as that of chimps, about the development of our species. We are learning more about ourselves and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.
Download the accompanying reference guide.©2015 John Parrington (P)2015 Audible, Inc.Listeners also enjoyed...
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-
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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The Vital Question
- Energy, Evolution, and the Origins of Complex Life
- By: Nick Lane
- Narrated by: Kevin Pariseau
- Length: 11 hrs and 27 mins
- Unabridged
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The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
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Ouch!
- By Mark on 06-24-16
By: Nick Lane
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The Accidental Mind
- How Brain Evolution Has Given Us Love, Memory, Dreams, and God
- By: David J. Linden
- Narrated by: Ray Porter
- Length: 7 hrs and 56 mins
- Unabridged
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You've probably seen it before: a human brain dramatically lit from the side, the camera circling it like a helicopter shot of Stonehenge, and a modulated baritone voice exalting the brain's elegant design in reverent tones... to which this book says: Pure nonsense.
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Best general-public Brain Science book to date
- By Francisco on 02-14-11
By: David J. Linden
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Evolving Ourselves
- How Unnatural Selection and Nonrandom Mutation are Changing Life on Earth
- By: Juan Enriquez, Steve Gullans
- Narrated by: Rob Shapiro
- Length: 10 hrs and 50 mins
- Unabridged
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Why are conditions like autism, asthma, obesity, and allergies exploding at unprecedented rates? Why are we living longer, getting smarter, having far fewer kids? If Darwin were alive today, how would he explain this new world?
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fascinating ideas and science
- By Joel on 07-04-15
By: Juan Enriquez, and others
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At the Edge of Uncertainty
- 11 Discoveries Taking Science by Surprise
- By: Michael Brooks
- Narrated by: Sean Runnette
- Length: 9 hrs and 12 mins
- Unabridged
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The atom, the big bang, DNA, natural selection - all are ideas that have revolutionized science; and all were dismissed out of hand when they first appeared. The surprises haven't stopped in recent years, and in At the Edge of Uncertainty, best-selling author Michael Brooks investigates the new wave of radical insights that are shaping the future of scientific discovery.
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All smoke, no fire
- By Kenton on 07-25-15
By: Michael Brooks
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What Is Life?
- How Chemistry Becomes Biology
- By: Addy Pross
- Narrated by: Derek Perkins
- Length: 6 hrs and 50 mins
- Unabridged
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Seventy years ago, Erwin Schrdinger posed a simple, yet profound, question: What is life?. How could the very existence of such extraordinary chemical systems be understood? This problem has puzzled biologists and physical scientists both before, and ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology?
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Profound & Life Changing...
- By Daegan Smith on 04-06-15
By: Addy Pross
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Know This
- Today's Most Interesting and Important Scientific Ideas, Discoveries, and Developments
- By: John Brockman
- Narrated by: Gabra Zackman, Dan John Miller
- Length: 14 hrs and 39 mins
- Unabridged
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Scientific developments radically alter our understanding of the world. Whether it's technology, climate change, health research, or the latest revelations of neuroscience, physics, or psychology, science has, as Edge editor John Brockman says, "become a big story, if not the big story". In that spirit this new addition to Edge.org's fascinating series asks a powerful and provocative question: What do you consider the most interesting and important recent scientific news?
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Pete and Repeat and Re-repeat
- By Daniel L on 02-25-18
By: John Brockman
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How Language Began
- The Story of Humanity's Greatest Invention
- By: Daniel L. Everett
- Narrated by: Jonathan Yen
- Length: 13 hrs and 10 mins
- Unabridged
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Mankind has a distinct advantage over other terrestrial species: we talk to one another. But how did we acquire the most advanced form of communication on Earth? Daniel L. Everett, a "bombshell" linguist and "instant folk hero" (Tom Wolfe, Harper's), provides in this sweeping history a comprehensive examination of the evolutionary story of language, from the earliest speaking attempts by hominids to the more than 7,000 languages that exist today.
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Hard to endure
- By Michael D. Busch on 09-09-18
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Herding Hemingway's Cats
- Understanding How Our Genes Work
- By: Kat Arney
- Narrated by: Kat Arney
- Length: 8 hrs and 39 mins
- Unabridged
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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?
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A non-scientists misguided interpretation
- By AraSevera on 05-15-16
By: Kat Arney
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The Ravenous Brain
- How the New Science of Consciousness Explains Our Insatiable Search for Meaning
- By: Daniel Bor
- Narrated by: Walter Dixon
- Length: 11 hrs and 15 mins
- Unabridged
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Consciousness is our gateway to experience: it enables us to recognize Van Gogh’s starry skies, be enraptured by Beethoven’s Fifth, and stand in awe of a snowcapped mountain. Yet consciousness is subjective, personal, and famously difficult to examine: philosophers have for centuries declared this mental entity so mysterious as to be impenetrable to science. In The Ravenous Brain, neuroscientist Daniel Bor departs sharply from this historical view, and proposes a new model for how consciousness works.
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Effectively demystifies consciousness
- By Gary on 11-18-12
By: Daniel Bor
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How to Build a Dinosaur
- Extinction Doesn't Have to Be Forever
- By: Jack Horner, James Gorman
- Narrated by: Patrick Lawlor
- Length: 6 hrs and 36 mins
- Unabridged
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In movies, in novels, in comic strips, and on television, we've all seen dinosaurs - or at least somebody's educated guess of what they would look like. But what if it were possible to build, or grow, a real dinosaur without finding ancient DNA? Jack Horner, the scientist who advised Steven Spielberg on the blockbuster film Jurassic Park and a pioneer in bringing paleontology into the 21st century, teams up with the editor of the New York Times's Science Times section to reveal exactly what's in store.
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Good book but misplaced title
- By Robert on 06-19-15
By: Jack Horner, and others
What listeners say about The Deeper Genome
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Max
- 11-26-19
amazingly good, and literate
amazingly good and very literate.
the author knows biology on the deep level.
the history is presented well
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Overall
- Amazon Customer
- 06-02-16
Better on "paper"
I thought there was a lot of good material well presented. But I'd recommend getting it as an ebook rather than an audiobook.
I'm finding lately that novela, social sciences, and "great courses" move at an appropriate pace for an audiobook. Heavier science books work better when uou can read them at your own pace, absorb the matetial, and reread a bit as needed.
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1 person found this helpful
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- R. N. Miranda
- 09-10-16
A thorough overview of modern molecular biology
This is a fascinating book about molecular biology. When I was feeling comfortable with some dogmas about inheritance and expression of DNA, we now receive a boost on epigenetics, regulatory switches, as well as how active the so-called "junk DNA" is. Life, biology and the understanding of diseases require much more from our attention.
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- Richard
- 11-24-15
Great Scientific Writing/ Wrong Narrator
Is there anything you would change about this book?
Yes, immediately. The narrator-John Lee- in my view, doomed this presentation from the start by using an unnecessary theatrical style with glottal perturbances extremely of -point for this type of work. Heres an example. Take a multi-syllable word : shout the first syllable as if on stage, then lightly whisper the next two at high speed. Do this over and over all throughout the book. You get the point. I found myself hitting the reverse button time after time to try to catch those faintly whispered nothings after recuperating from the bling of the first syllable blasted like a sharp report. It's true that the American ear is often not adapted to the nuances of the mother tongue, but am I correct in sensing a lot of Scottish churn charged up with theatrical training here? It doesn't matter- I'll not follow him in the future except perhaps on the Shakespeare classics front if that ever happens.One more vexing verbal twitch to mention, and this stems from the authorship: the most overused word in the entire treatise is "however". You'll hear it shouted, hurled in a snippish manner, used to lead off hundreds of sentences, over and over and eventually this became a form of verbal torture. Surely there are more varied ways to introduce sentences.However, this would have been a great book otherwise, however.
What did you like best about this story?
Disregarding the interruptive delivery discussed above, John Parrington ably constructed a plausible explanation of current views on the subject and nicely integrated historical context all the way along. I have a deep background in biological sciences so the terms and concepts were easily understood, though new in so many cases for me. Just learning the dynamics of histones made it all worth it. That was refreshing, and yes I'm kind of a science nut.
Who would you have cast as narrator instead of John Lee?
Kevin Pariseau, unequivocally
If this book were a movie would you go see it?
I can't imagine how this could be presented as a movie unless as an educational theme with explanatory three- dimensional diagrams and Uma Thurman acting it out in some Sci-fi co-opt.
Any additional comments?
If you're prepared to bear up to what was, in my opinion, a disruptive narrator I would recommend this book highly. The information therein is solid gold. You may come away with a revised view of genetics and biological evolution. I know I did. I would hope that Dr. Parrington will quickly write on other topics in the future along these lines, as well as to further expand on today's current vital quest to dig more deeply into genomics.
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14 people found this helpful
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- Timothy
- 07-31-15
Genome-Just what is it? Described and more
Would you recommend this audiobook to a friend? If so, why?
Well written history of Genetics & Molecular Biology, detailing the important events and key people, explained at a basic biology level with a pleasant narration. Throughout the book, technology and scientific advancement are discussed which leads to what we know and more importantly what is not known and what the future may bring. I was disappointed that the book did not discuss the latest new big breakthrough in gene editing, CRISPR. I think this is important enough to have delayed publishing of this book or addressing through a late edition in an epilogue. If this book interested you, you will want to followup on CRISPR. Be sure to get the free accompanying figure as a PDF file by using the link at the time of purchase.
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8 people found this helpful
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- Amazon Customer
- 10-12-16
Good content spoiled by rendition
Terrible audio quality. The distortion made it even harder to follow the narrator's mediocre reading and his occasional truly odd pronunciation of terminology. My only criticism of the content is that I was a bit amused at the author's apparent obsession with when all the important players were awarded their Nobel prizes. Other than that, it was a good review of the subject from a knowledgeable insider.
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2 people found this helpful
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- Shachar Petrushka
- 02-07-17
very scientific, lots of data, not an easy listen
What could have made this a 4 or 5-star listening experience for you?
Took me a bit of a while to figure out why I'm having a problem with this book.
The book does contain a lot of scientific data, quotes and facts but the problem is is that it uses too much of a high language and quotes and scientific words that I found it really hard to follow it while driving.
I was looking for a simpler more of a story book.
Not that I have a problem with the English language but I was looking more of a simple fact like: research found that this do that
instead you get a lot of: "R-Transdocers encode DNA, the epigenetic changes influenced by the environment and life experiences"
and lots of other sentences similar to this (this isn't an exact quote, just an example) which makes it very difficult to follow the audio book while driving.
Also the explanation for genes changing between generations is explained only on the last 1/3 of the book. (an example is given about Holland in ww1 or 2 that the population were starving and they've discovered that pregnant female that were starved gave birth to children who were more inclined to obesity, even their grandchildren still have this gene inclination)
Were the concepts of this book easy to follow, or were they too technical?
The book was not easy to follow and was more technical then I expected and therefor is no fit to listen while driving
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