The Epigenetics Revolution
How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance
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Narrated by:
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Donna Postel
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By:
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Nessa Carey
About this listen
Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies, why tortoiseshell cats are always female, why some plants need cold weather before they can flower, and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.
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A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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The future of medicine
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A Crack in Creation
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
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p53: The Gene That Cracked the Cancer Code
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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Herding Hemingway's Cats
- Understanding How Our Genes Work
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- Narrated by: Kat Arney
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Overall
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Performance
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Story
The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work?
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A non-scientists misguided interpretation
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By: Kat Arney
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An Epidemic of Absence
- A New Way of Understanding Allergies and Autoimmune Diseases
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- Narrated by: Chris Sorensen
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An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.
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The point of view from a Veterinarian immunologist
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Sicker, Fatter, Poorer
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Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we’ve turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he reveals what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.
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The Must Read Book of 2019 is here early on Audio!
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The Vital Question
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The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.
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Ouch!
- By Mark on 06-24-16
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Missing Microbes
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In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
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Very enlightening and information well supported
- By James on 05-03-15
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The Cancer Chronicles
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When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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A quick read - hard to put down
- By Digital Dilema on 09-06-13
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Creation
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What is life? Humans have been asking this question for thousands of years. But as technology has advanced and our understanding of biology has deepened, the answer has evolved. For decades, scientists have been exploring the limits of nature by modifying and manipulating DNA, cells, and whole organisms to create new ones that could never have previously existed on their own.
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The Goldilocks book on what is life
- By Gary on 07-11-13
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The Accidental Mind
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You've probably seen it before: a human brain dramatically lit from the side, the camera circling it like a helicopter shot of Stonehenge, and a modulated baritone voice exalting the brain's elegant design in reverent tones... to which this book says: Pure nonsense.
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Best general-public Brain Science book to date
- By Francisco on 02-14-11
By: David J. Linden
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I wish this book was in American high schools.
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Decent Overview. Could lose sarcasm.
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top notch!
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What listeners say about The Epigenetics Revolution
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- bana
- 11-14-17
Technical, but you don't need a bio degree
I was always fascinated by epi genetics. Picked up Coursera courses and watched YouTube video. but they were either too hand wavy or you needed a background in biology. This book was the best material I have seen about epi genetics. It lacks the coherence of a survey in a mature field but it is not the writers fault; the since is at it's day one.
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- Mike
- 06-16-17
Maybe A Bit Over My Head But Great Performance
Where does The Epigenetics Revolution rank among all the audiobooks you’ve listened to so far?
This is an admission I probably shouldn't make. If I don't feel like giving a book a 4 or 5 star I refrain from ranking it thinking I just didn't get it. If I feel like I wasted my money I do rank 1 star. If it weren't for the enthusiastic reading I would have not rated this book.
Any additional comments?
This is an amazing topic with so much happening that even though I only got 10% of the facts, I am now a 100% believer that this is important work.
Thank you Nesa Carey for even trying to explain it to me and thank you Donna Postel for keeping me listening.
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12 people found this helpful
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- Travis Brooks
- 04-30-19
It stays interesting
So many books written for the layperson about complex topics seem to blow through the relevant, interesting content in the first third, and spend the latter two thirds re-iterating it. This book lays groundwork, then takes the reader through manifold different arenas that the subject touches. Loved it.
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1 person found this helpful
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- T. Lohman
- 03-20-21
A little over my head
Even as a medical professional, i was lost at times. I did like her metaphors.
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- Olena
- 05-24-23
Excellent
Very informative and educating, wonderfully written and performed. Easy to follow even for non scientists, yet contains many new precious gems for scientists too
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- Thomas
- 08-15-17
A Clear & Detailed Explanation Of Epigenetics
Would you listen to The Epigenetics Revolution again? Why?
Yes-
Have already listened to some chapters 3x
What did you like best about this story?
The clear explanations and analogies of complex issues -
What does Donna Postel bring to the story that you wouldn’t experience if you just read the book?
Clear voice and doesn't accentuate the S's
If you were to make a film of this book, what would the tag line be?
Any additional comments?
As an avid science reader this book is a good one- Am ordering the print version tonight
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5 people found this helpful
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- Dominic Acri
- 08-28-19
Great for beginner to intermediate epigeneticists
Historical perspectives on the beginning of epigenetics covers much of the basics that would be covered in an undergraduate course. The focus is basic with a good narrative. Not recommended for those looking for in depth snapshot into current views of epigenetics.
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- Jase G
- 01-27-23
Great intro to epigenetics, a bit cloying at times
The book gets more specific and technical as it goes on, so you may want to skip early chapters if you already know such 101 material as how a zygote becomes an embryo.
I found most of the subject matter in the second half of the book pretty interesting, if fairly shallow on a technical level. It's an easy read that whetted my interest in epigenetics, and will probably lead to me reading more books on the topic.
There were a number of things I didn't care for, which caused me to drop my overall score.
I tired *very* quickly of Carey's feeble, tedious attempts to conjure drama out of anecdotes about the scientists. Here's one example:
"This was a risk for an established scientist like Yamanaka, but it was an even bigger gamble for a relatively junior associate like Takahashi, because of the way that the scientific career ladder works...."
Skip it. Yamanaka and Takahashi can put it in their memoirs. I won't buy them, Carey will, and we'll all have what we want.
I also wearied of Carey's constant flattery of the scientists she discussed. I don't know if they're personal friends, but every one of them is described charming, brilliant, attractive, and humble. Even if I cared about these people (I don't, I want to learn about epigenetics) the paeans are hardly useful in learning about them.
The book would have been considerably denser on useful information with these things subtracted.
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- Philomath
- 07-06-17
The complicated world of epigenetics
Just when we thought that genetic information does not get affected by the environment as Darwin had solidified, we discover Lemarkien evolution at work.
What does this exactly mean. Well, the environment affects our genes which can and are handed down to our offsprings. Jean-Baptise Lamarck has been somewhat vindicated by discoveries that prove certain adaptations occurs during the lifetime of animals and plants which in some cases improves the fitness and survivability of the animal and more importantly those traits are handed down generations.
The subject is fascinating, but this book is far too complicated for anyone who has not studied the subject, and is well versed in the lingo.
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- Usizael
- 03-01-19
Great, and informative book...
Epigenetics is a fascinating field. this book does a great job at explaining it. it still gets in the weeds, but it makes sense. loved the book.
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3 people found this helpful