Three generations of the Brown women travel west together on the Oregon Trail, but each seeks something different. When the trail divides, a decision must be made that could bring survival or tragedy. The challenges faced will form the character of one woman - and impact the future for many more.

After the final battle of the Civil War, Confederate Sergeant Travis Kane rode his Yankee horse away from Palmito Ranch to return to his ranch in Uvalde County. As he began the two-hundred-and-fifty-mile ride across West Texas, Travis was grateful for surviving the long, bloody war without being wounded. But now that the fighting was over, his biggest concern was for his young wife because he hadn’t received a letter from Lillian in almost two years.

Raised in the hills of Tennessee, Emma Simms dreams of the day she’ll escape her life of poverty to start over in the excitement of Knoxville. But when her mother dies and she’s left with no one but her stepfather, Luke Simms, her dream abruptly becomes a nightmare. Luke plans to send Emma to Knoxville all right - straight to a notorious brothel. River Joe, the mysterious Cherokee-raised frontiersman, knew from the first time he set eyes on the beautiful Emma that he had to have her as his own.

Orphaned at fourteen, Hector “Heck” Martin heads west, determined to see the far country and make a man of himself. Along the way, he falls in love with bold and beautiful Hope Mullen. But Heck is too young and poor to marry, so he heads west again. During a three-year journey, Heck crosses thousands of miles, becomes a bareknuckle boxer, a mountain man, and an Indian fighter, and meets the likes of Kit Carson and Jim Bridger as he explores the gorgeous and deadly frontier.

Alice Wright marries handsome American Bennett Van Cleve hoping to escape her stifling life in England. But small-town Kentucky quickly proves equally claustrophobic, especially living alongside her overbearing father-in-law. So, when a call goes out for a team of women to deliver books as part of Eleanor Roosevelt’s new traveling library, Alice signs on enthusiastically. The leader, and soon Alice's greatest ally, is Margery, a smart-talking, self-sufficient woman who's never asked a man's permission for anything.

The Overland Trail, 1853: Naomi May never expected to be widowed at 20. Eager to leave her grief behind, she sets off with her family for a life out West. On the trail, she forms an instant connection with John Lowry, a half-Pawnee man straddling two worlds and a stranger in both. But life in a wagon train is fraught with hardship, fear, and death. Even as John and Naomi are drawn to each other, the trials of the journey and their disparate pasts work to keep them apart.

Eastern Kentucky, 1937. After the death of her husband, Ada Donovan returned home to live again with her aging parents. She does all she can to help them keep the small family farm going. But times are hard, and there’s never enough. During one of her infrequent visits to town, she sees a help-wanted notice for the Pack Horse Librarian Project, seeking librarians to ride up high in the mountains and bring books to the people there. Before her marriage, Ada was a teacher, and the thought of returning to the work she loved is impossible to resist.

A sheltered ranch wife and her friends trade their dresses for workpants to take on the rigors of a cattle drive - but the challenges are even greater than they imagined. Will they overcome with hearts and humor intact? Will they survive at all?

Ambition drove Joe Dollarhide across the parched plains from Fort Sam Houston to Dodge City. One day, he was determined to have a spread every bit as vast and impressive as his employer's. But when a wild stampede separates him from the cattle drive, it is survival that keeps him going when most would have given up. Survival and a burning need to settle the score with Benteen Calder, the cattle boss he used to worship, the man who left him for dead.

Larkspur Nielsen is ready for a change. Her parents have passed on, and her older brother is successfully running the family business. She bristles at the small-mindedness that permeates life in her small Ohio community, and she sees little chance of a satisfying future there. She has a little money saved, and after turning the tables on a crooked gambler who had fleeced several locals, including her younger brother, she can stake a new start for herself and her three sisters.

Wynne Elliott is tracking down Cass Claxton, the scoundrel who ran off with her money just before the start of the war and left her standing at the altar. Now that the fighting has ended, Wynne wants her revenge. But she never expects Cass' older brother, the handsome Cole, to steal her heart. Can an obstinate, "addlebrained" Southern belle be a match for this intractable, "pompous idiot" cowboy?

Cora feels indebted to the man, Eddie, who saved her and her baby Esther. She travels on the Oregon Trail with him. He intimidates her and has her doing most of the work. He’s jealous, and she knows not to look in another man’s direction. An early snowstorm leaves her in danger of frostbite, and when Harrison Walsh carries her off to his wagon to be treated, Eddie becomes enraged and drops Cora’s trunk off at Harrison’s wagon. Harrison Walsh was happily married until three months ago, when his wife died.

Greta Nilsson's trip west to save her ailing little sister, Astrid, could not have gone more wrong. First, bandits hold up her stagecoach, stealing all her money. Then, upon arriving in Fairplay, Colorado, she learns the man she was betrothed to as a mail-order bride has died. Homeless, penniless, and jobless, Greta and her sister are worse off than when they started.

Hoping to escape the shame of her street urchin's life in Boston, Anna Reardon plotted a desperate scheme - to become Karl Lindstrom's mail-order bride in the beautiful, dangerous frontier of Minnesota. A kind and gentle man, Karl forgave Anna for her deceptions. But there was still one burning secret she had to hide from him, knowing its revelation would destroy the love they had come to cherish.

It's February, 1852, and all around Chicago, Maggie sees postings soliciting "eligible women" to travel to the gold mines of Goosetown. A young seamstress with a small daughter, she has nothing to lose. She joins 43 other women and two pious reverends on the dangerous 2,000-mile journey west. None are prepared for the hardships they face on the trek or for the strengths they didn't know they possessed. Maggie discovers she’s not the only one looking to leave dark secrets behind.