Danielle Wright has had an illustrious career as a nurse, but when the unthinkable happens, she has nowhere to run to get out of the gaze of prying eyes and judgmental people. When she takes a job as the nurse for Wisteria Island, she has no clue what she's agreeing to. The brainchild of a wealthy entrepreneur, Wisteria Island is home to a cast of quirky, and often difficult, characters. When Danielle finds out why the previous eight nurses have all quit within days, she has to decide whether to stick it out or go back to a life she no longer recognizes.

Mia Carter's life has always been about her family and their charming bed and breakfast in the idyllic Blue Ridge Mountains. When her mother passes away, Mia is left to run the Sweet Tea B&B alone. But a routine DNA test changes everything. Mia discovers she has a sister named Kate, who lives in Rhode Island. The sisters meet for the first time at the will reading and are shocked to learn that their mother's final wish was for them to run the B&B together.

When the Chambers sisters receive an invitation from their jet-setting aunt to spend the entire month of December at the family's cabin in Asheville, North Carolina, they have one question—why? The retreat, tucked into the Blue Ridge Mountains, may be the site of many happy childhood holidays and summers, but it also holds sad memories. The sisters and their aunt have spent twenty-five years avoiding the cabin and renting it to strangers. Why would Aunt Elizabeth want her "dearest darling" nieces to put their busy lives in three different states on hold and spend a month in the mountains?

Josie Campbell has spent her entire adult life distancing herself from her childhood in the small Southern town of Happy Harbor. Growing up with an alcoholic mother who was either absent or scandalizing the town with her antics, all Josie ever wanted was to escape to somewhere no one knew her. Now, she finally has it all—a great job, a condo in one of Atlanta’s most desirable areas, a successful fiancé, and her daughter, Kendra, enrolled at a top-rated school. But when that life falls apart, and her beloved nana dies, Josie is forced to return to the one place she never wanted to visit again.

Quinn came to Whiskey Ridge with a secret. He never expects the woman sharing an office with him might uncover it accidentally. Kelly just wanted to run away from her problems. She needs order and quiet, but her neighbor is driving her crazy. Plus, he’s a little too attractive, and she doesn’t need that right now.