In clinic, treating patients for IBS is only one piece of the puzzle. Overlapping disorders are common in IBS. Drs Lin Chang and Magnus Simrén discuss the nuances of this condition.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987263). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Irritable Bowel Syndrome (IBS) https://emedicine.medscape.com/article/180389-overview

Gastroesophageal Reflux Disease https://emedicine.medscape.com/article/176595-overview

Approach to Disorders of Gut-Brain Interaction https://pubmed.ncbi.nlm.nih.gov/36868754/

Inflammatory Bowel Disease https://emedicine.medscape.com/article/179037-overview

Prevalence of Irritable Bowel Syndrome-Like Symptoms Using Rome IV Criteria in Patients With Inactive Inflammatory Bowel Disease and Relation With Quality of Life https://pubmed.ncbi.nlm.nih.gov/32384473/

Celiac Disease (sprue) https://emedicine.medscape.com/article/171805-overview

Prevalence of Irritable Bowel Syndrome-Type Symptoms in Patients With Celiac Disease: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/23246645/

Gastroesophageal Reflux Disease, Functional Dyspepsia and Irritable Bowel Syndrome: Common Overlapping Gastrointestinal Disorders https://pubmed.ncbi.nlm.nih.gov/30386113/

Rome IV Criteria https://theromefoundation.org/rome-iv/rome-iv-criteria/

Neuromodulators in the Brain-Gut Axis: Their Role in the Therapy of the Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34812436/

Cognitive Behavioral Therapy for IBS and Other FGIDs https://iffgd.org/resources/publication-library/cognitive-behavioral-therapy-for-ibs-and-other-fgids/

Proton Pump Inhibitors (PPI) https://www.ncbi.nlm.nih.gov/books/NBK557385/

Central Sensitization and Severity of Gastrointestinal Symptoms in Irritable Bowel Syndrome, Chronic Pain Syndromes, and Inflammatory Bowel Disease https://pubmed.ncbi.nlm.nih.gov/33860970/

A Distinctive Profile of Family Genetic Risk Scores in a Swedish National Sample of Cases of Fibromyalgia, Irritable Bowel Syndrome, and Chronic Fatigue Syndrome Compared to Rheumatoid Arthritis and Major Depression https://pubmed.ncbi.nlm.nih.gov/35354508/

Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the Lifelines Cohort Study https://pubmed.ncbi.nlm.nih.gov/25768845/

Defining Optimal Care for Functional Gut Disorders - Multi-Disciplinary Versus Standard Care: A Randomized Controlled Trial Protocol https://pubmed.ncbi.nlm.nih.gov/31437539/

Can brain-gut behavioral therapies reduce IBS symptoms, not just mood and psychological symptoms? Drs Lin Chang and Laurie Keefer discuss why incorporating this therapy in your practice works.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987262). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Irritable Bowel Syndrome (IBS) https://emedicine.medscape.com/article/180389-overview

Benson-Henry Institute for Mind Body Medicine https://bensonhenryinstitute.org/mission-history/

Microbiome https://www.genome.gov/genetics-glossary/Microbiome

Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders https://pubmed.ncbi.nlm.nih.gov/29593576/

Burden of Anxiety and Depression Among Hospitalized Patients With Irritable Bowel Syndrome: A Nationwide Analysis https://pubmed.ncbi.nlm.nih.gov/36593438/

A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction https://pubmed.ncbi.nlm.nih.gov/34529986/

Cognitive-Behavioral Therapy for IBS and Other FGIDs https://iffgd.org/resources/publication-library/cognitive-behavioral-therapy-for-ibs-and-other-fgids/

App-Delivered Gut-Directed Hypnotherapy Program Nerva Improves Symptoms in Patients With Irritable Bowel Syndrome but How Can We Ensure Users Are Compliant? https://gi.org/media/press-info-scientific-meeting/featured-science/oral-15

The Role of Resilience in Irritable Bowel Syndrome, Other Chronic Gastrointestinal Conditions, and the General Population https://pubmed.ncbi.nlm.nih.gov/32835842/

How do you help patients with soft stool that won't move through manage idiopathic constipation? Join Drs Lin Chang and Anthony Lembo as they discuss nuanced decision-making around treating IBS subtypes.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987261). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Irritable Bowel Syndrome (IBS) https://emedicine.medscape.com/article/180389-overview

Sigmoid Afferent Mechanisms in Patients With Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/9201070/

Peripheral Opioids for Functional GI Disease: A Reappraisal https://pubmed.ncbi.nlm.nih.gov/16699267/

Dietary Concerns and Patient-Focused Care in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36398143/

The Epidemiology of Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/24523597/

Diagnosis and Treatment of Irritable Bowel Syndrome: A Review https://pubmed.ncbi.nlm.nih.gov/33651094/

Review Article: An Integrated Approach to the Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/10429736/

AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Diarrhea https://pubmed.ncbi.nlm.nih.gov/35738725/

Psyllium Reduces Inulin-Induced Colonic Gas Production in IBS: MRI and in Vitro Fermentation Studies https://pubmed.ncbi.nlm.nih.gov/34353864/

Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/30144426/

How do you identify postinfection irritable bowel syndrome? How long will it last and how do you treat it? Join expert physicians Lin Chang and Madhu Grover as they discuss.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987260). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Post-Infection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34024451/

Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery https://pubmed.ncbi.nlm.nih.gov/16890598/

Sex-Gender Differences in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/30347934/

Prevalence of Gastrointestinal Symptoms Six Months After Bacterial Gastroenteritis and Risk Factors for Development of the Irritable Bowel Syndrome: Postal Survey of Patients https://pubmed.ncbi.nlm.nih.gov/9080994/

The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/21256129/

Randomised Placebo-Controlled Trial of Dietary Glutamine Supplements for Postinfectious Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/30108163/

Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36858143/

Double-blind Placebo-Controlled Study of Mesalamine in Post-Infective Irritable Bowel Syndrome – A Pilot Study https://pubmed.ncbi.nlm.nih.gov/22783919/

Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/28846594/

The COVID-19 Pandemic and Post-Infection Irritable Bowel Syndrome: What Lies Ahead for Gastroenterologists https://pubmed.ncbi.nlm.nih.gov/35944588/

The Prevalence of Irritable Bowel Syndrome After Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Their Association: A Systematic Review and Meta-Analysis of Observational Studies https://pubmed.ncbi.nlm.nih.gov/36902651/

Postinfection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34789582/

COVID-19 as a Trigger of Irritable Bowel Syndrome: A Review of Potential Mechanisms https://pubmed.ncbi.nlm.nih.gov/34887641/

Incidence and Predisposing Factors for De Novo Post-COVID-19 Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36468570/

Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/32916129/

Serine Proteases as Luminal Mediators of Intestinal Barrier Dysfunction and Symptom Severity in IBS https://pubmed.ncbi.nlm.nih.gov/30923071/

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy https://pubmed.ncbi.nlm.nih.gov/28274108/

Performance and Interpretation of Hydrogen and Methane Breath Testing Impact of North American Consensus Guidelines https://pubmed.ncbi.nlm.nih.gov/35366119/

Join Drs Lin Chang and Bill Chey as they discuss the complicated relationship that patients living with IBS have with food. In this episode they'll cover special diets, disordered eating, and more.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987259). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Irritable Bowel Syndrome (IBS) https://emedicine.medscape.com/article/180389-overview

Rome Foundation https://theromefoundation.org/

Irritable Bowel Syndrome and Dietary Interventions https://pubmed.ncbi.nlm.nih.gov/30899204/

Food Allergies and Intolerances: A Clinical Approach to the Diagnosis and Management of Adverse Reactions to Food https://pubmed.ncbi.nlm.nih.gov/33493695/

Confocal Laser Endomicroscopy in Gastro-intestinal Endoscopy: Technical Aspects and Clinical Applications https://pubmed.ncbi.nlm.nih.gov/35243116/

IgG Food Antibody Guided Elimination-rotation Diet Was More Effective Than FODMAP Diet and Control Diet in the Treatment of Women With Mixed IBS-Results From an Open Label Study https://pubmed.ncbi.nlm.nih.gov/34640335/

A Leukocyte Activation Test Identifies Food Items Which Induce Release of DNA by Innate Immune Peripheral Blood Leucocytes https://pubmed.ncbi.nlm.nih.gov/29651299/

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-sponsored Expert Panel https://pubmed.ncbi.nlm.nih.gov/21134576/

High FODMAP Diet Causes Barrier Loss via Lipopolysaccharide-mediated Mast Cell Activation https://pubmed.ncbi.nlm.nih.gov/34618688/

Microbiome and Gut Dysbiosis https://pubmed.ncbi.nlm.nih.gov/30535609/

Irritable Bowel Syndrome in Adults: Diagnosis and Management https://pubmed.ncbi.nlm.nih.gov/32073807/

Trending Clinical Topic: Mediterranean Diet https://reference.medscape.com/viewarticle/958654

Low-FODMAP Diet for Irritable Bowel Syndrome: What We Know and What We Have Yet to Learn https://pubmed.ncbi.nlm.nih.gov/31986083/

A Diet Low in FODMAPS Reduces Symptoms in Patients With Irritable Bowel Syndrome and a Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/28625832/

The Low FODMAP Diet https://www.monashfodmap.com/

9 Things to Know About ARFID https://www.medscape.com/viewarticle/989155#vp_3

Randomized Trial of Medical Versus Surgical Treatment for Refractory Heartburn https://pubmed.ncbi.nlm.nih.gov/31618539/

Proton Pump Inhibitors (PPI) https://www.ncbi.nlm.nih.gov/books/NBK557385/

GI Institute https://giinstitute.com/

Human Metabolome Database: Completing the 'Human Parts List' https://www.medscape.com/viewarticle/561698_2

Bile Acid and Gut Microbiota in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/36250362/

Drs Lin Chang and Douglas Drossman discuss the history of IBS, the gut-brain axis, and the role of trauma and stress in IBS, and share pearls for implementing biopsychosocial care in the clinic.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987258). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

IBS and Chronic Constipation https://www.medscape.com/resource/ibs

The Need for a New Medical Model: A Challenge for Biomedicine https://pubmed.ncbi.nlm.nih.gov/847460/

The Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/892385/

Rome IV Criteria https://theromefoundation.org/rome-iv/rome-iv-criteria/

William E. Whitehead, PhD https://www.med.unc.edu/ibs/about-us/faculty-biographies/william-e-whitehead/

Program Treats Complex GI and Swallowing Disorders https://hscweb3.hsc.usf.edu/blog/2012/01/04/program-treats-complex-gi-and-swallowing-disorders/

Post-infection Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/34024451/

Psychosocial Factors in Gastrointestinal Illness https://pubmed.ncbi.nlm.nih.gov/8416089/

To Be a Great Physician, You Must Understand the Whole Story https://pubmed.ncbi.nlm.nih.gov/17435659/

Validation of Symptom-Based Diagnostic Criteria for Irritable Bowel Syndrome: A Critical Review https://pubmed.ncbi.nlm.nih.gov/20179688/

Effect of Abuse History on Pain Reports and Brain Responses to Aversive Visceral Stimulation: An FMRI Study https://pubmed.ncbi.nlm.nih.gov/18242208/

Toward a Biobehavioral Model of Visceral Hypersensitivity in Irritable Bowel Syndrome https://pubmed.ncbi.nlm.nih.gov/9859851/

A Review of the Evidence and Recommendations on Communication Skills and the Patient-Provider Relationship: A Rome Foundation Working Team Report https://pubmed.ncbi.nlm.nih.gov/34331912/

Rome Foundation — Johannah's Story https://theromefoundation.org/johannahs-story/