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Schopenhauer, the "philosopher of pessimism", makes it very plain that he regards the world and our life in it as a bad joke. But if the world is indifferent to our fate, it doesn't thwart us on purpose. The world's facade is supported by what Schopenhauer calls the Universal Will, blind and without purpose. This Will brings on all our misery and suffering; our only hope is to liberate ourselves from its power and from the trappings of individualism and egoism that are at its mercy.

Against the background of an age that saw the rebirth of ancient and classical learning, Paul Strathern explores the intensely dramatic rise and fall of the Medici family in Florence as well as the Italian Renaissance, which they did so much to sponsor and encourage. Interwoven into the narrative are the lives of many of the great Renaissance artists with whom the Medici had dealings, including Leonardo, Michelangelo, and Donatello as well as scientists like Galileo and Pico della Mirandola.

The Borgia family have become a byword for evil. Corruption, incest, ruthless megalomania, avarice, and vicious cruelty - all have been associated with their name. And yet, paradoxically, this family lived when the Renaissance was coming into its full flowering in Italy. Examples of infamy flourished alongside some of the finest art produced in western history.

Spinoza's brilliant metaphysical system was derived neither from reality nor experience. Starting from basic assumptions, with a series of geometric proofs he built a universe which was also God, one and the same thing, the classic example of pantheism. Although his system seems an oddity today, Spinoza's conclusions are deeply in accord with modern thought, from science (the holistic ethics of today's ecologists) to politics (the idea that the state exists to protect the individual).

Rene Descartes spent most of his childhood in solitude, a situation that also came to characterize his adult life. Fortunately, these countless lonely hours helped Descartes produce the declaration that changed all philosophy: "I think, therefore I am." Eventually convincing himself to doubt and disregard sensory knowledge, Descartes found he could prove his existence through his thoughts. This internal information, he believed, was the true reality and external forces were hopelessly deceiving.

Kierkegaard wasn't really a philosopher in the academic sense. Yet he produced what many people expect of philosophy. His subject was the individual and his or her existence, the "existing being." In Kierkegaard's view, this purely subjective entity lay beyond the reach of reason, logic, philosophical systems, theology, or even "the pretenses of psychology." Nonetheless, it was the source of all these subjects. The branch of philosophy to which Kierkegaard gave birth has come to be known as existentialism.

"If we accept Wittgenstein's word for it," Paul Strathern writes, "he is the last philosopher. In his view, philosophy in the traditional sense was finished."

A handsome recluse, plagued by indecision and hypochondria, Franz Kafka nonetheless exhibited an extraordinary strength. He developed the uncanny ability to observe himself with cool objectivity, and he cultivated this ability in his writing, where it appeared in increasingly original metaphorical form. His works became among the greatest of the twentieth century, and his influence permeated far and wide, transcending literature.

Latin American literature was never primitive; yet, from its beginnings, it was suffused with a fresh, often childish lyricism. Gabriel Garcia Marquez stands on the shoulders of a great Latin American literary heritage, but he is a modern rarity: a writer with aspirations to high art who also remains hugely popular. For those who fall under his spell, his novel One Hundred Years of Solitude is one of the richest literary dreams ever written.

Leonardo da Vinci, Niccolò Machiavelli, and Cesare Borgia - three iconic figures whose intersecting lives provide the basis for this astonishing work of narrative history. They could not have been more different, and they would meet only for a short time in 1502, but the events that transpired when they did would significantly alter each man's perceptions - and the course of Western history.

We see our age as the greatest in human history, filled with seemingly unending originality. Yet such dynamism is not a necessary characteristic of great eras. Among the most long-lasting and stable civilizations was that of medieval Europe. There stasis was achieved, and with it a stability that permitted the development of structured thought and intellectual embellishment of unparalleled degree.

From a young age, James Joyce showed a precocious and original intellect and a confidence in his own artistic destiny. He would indeed go on to transform the nature of modern literature, employing a unique stream-of-consciousness technique rich in symbolism and wordplay. Through his art, the Dublin native sought to reveal the radiance and meaning that lurks in the everyday world - "the soul of the commonest object" - evoking a heightened sense of consciousness within the grit of common life.

David Hume reduced philosophy to ruins: he denied the existence of everything, except our actual perceptions themselves. I alone exist, he argued, and the world is nothing more than part of my consciousness. Yet we know that the world remains, and we go on as before. What Hume expressed was the status of our knowledge about the world, a world in which neither religion nor science is certain.

With Friedrich Nietzsche, philosophy was dangerous not only for philosophers but for everyone. His ideas presaged a collective madness that had horrific consequences in Europe in the early 1900s. Though his philosophy is more one of aphorisms than a system, it is brilliant, persuasive, and incisive. His major concept is the will to power, which he saw as the basic impulse for all our acts. Christianity he saw as a subtle perversion of this concept, thus Nietzsche's famous pronouncement, "God is dead."

In Rousseau we encounter a walking ego, naked sensibility. Feeling triumphs over intellectual argument in his works, which are both deeply stirring and deeply inconsistent. Yet while his contemporaries Kant and Hume may have been superior academic philosophers, the sheer power of Rousseau's ideas was unequaled in his time. It was he who encouraged the introduction of both liberty and irrationality into the public domain.

However, a historical transformation of similar magnitude also took place in northern Europe at the same time. This "Other Renaissance" was initially centered on the city of Bruges in Flanders (modern Belgium), but its influence was soon being felt in France, the German states, London, and even in Italy itself.

In an age when philosophers had scarcely glimpsed the horizons of the mind, a boy named Aristocles decided to forgo his ambitions as a wrestler. Adopting the nickname Plato, he embarked instead on a life in philosophy. In 387 B.C. he founded the Academy, the world's first university, and taught his students that all we see is not reality but merely a reproduction of the true source. And in his famous Republic he described the politics of "the highest form of state."

One of the two major philosophical traditions of the twentieth century was linguistic analysis, derived largely from Wittgenstein. The other, diametrically opposed, came from Heidegger, and its fundamental question was, "What is the meaning of existence?" For Heidegger, this question could not simply be "analyzed away". It was beyond the reach of logic or reason. It was the primary "given" of every individual life. To confront it, Heidegger needed to develop an entire new form of philosophy.

Between the birth of Dante in 1265 and the death of Galileo in 1642, something happened that transformed the entire culture of Western civilization. Painting, sculpture, and architecture would all visibly change in such a striking fashion that there could be no going back on what had taken place. Likewise, the thought and self-conception of humanity would take on a completely new aspect. Sciences would be born - or emerge in an entirely new guise.

Confucius knew all about life and told us how to behave, but we can't find out precisely what he was up to. His well-meaning platitudes, quaint maxims, and quasi-enigmatic anecdotes combined to produce an ideal philosophy for civil servants. It would appear that his aim was to turn his pupils into good government officials, but his teachings succeeded beyond his wildest expectations, providing rules of conduct and spiritual fodder for more than two thousand years.