Real Americans begins on the precipice of Y2K in New York City, when twenty-two-year-old Lily Chen, an unpaid intern at a slick media company, meets Matthew. Matthew is everything Lily is not: easygoing and effortlessly attractive, a native East Coaster and, most notably, heir to a vast pharmaceutical empire. Lily couldn't be more different: flat-broke, raised in Tampa, the only child of scientists who fled Mao’s Cultural Revolution. Despite all this, Lily and Matthew fall in love.

From Pulitzer finalist, MacArthur Fellowship recipient, and bestselling author of Swamplandia! and Vampires in the Lemon Grove Karen Russell comes a gripping dust bowl epic about five characters whose fates become entangled after a storm ravages their small Nebraskan town The Antidote opens on Black Sunday, as a historic dust storm ravages the fictional town of Uz, Nebraska. But Uz is already collapsing—not just under the weight of the Great Depression and the dust bowl drought, but beneath its own violent histories.

As an Indian wedding gathers a family back together, parents Rafiq and Layla must reckon with the choices their children have made. There is Hadia, their headstrong eldest daughter, whose marriage is a match of love and not tradition. Huda, the middle child, determined to follow in her sister’s footsteps. And lastly, their estranged son, Amar, who returns to the family fold for the first time in three years to take his place as brother of the bride.

Chiamaka is a Nigerian travel writer living in America. Alone in the midst of the pandemic, she recalls her past lovers and grapples with her choices and regrets. Zikora, her best friend, is a lawyer who has been successful at everything until—betrayed and brokenhearted—she must turn to the person she thought she needed least. Omelogor, Chiamaka’s bold, outspoken cousin, is a financial powerhouse in Nigeria who begins to question how well she knows herself. And Kadiatou, Chiamaka’s housekeeper, is proudly raising her daughter in America—but faces an unthinkable hardship.

Sara Marsala barely knows who she is anymore after the failure of her business and marriage. On top of that, her beloved great-aunt Rosie passes away, leaving Sara bereft with grief. But Aunt Rosie’s death also opens an escape from her life and a window into the past by way of a plane ticket to Sicily, a deed to a possibly valuable plot of land, and a bombshell family secret. Rosie believes Sara’s great-grandmother Serafina, the family matriarch who was left behind while her husband worked in America, didn’t die of illness as family lore has it . . . she was murdered.

When Lenna gets a call from her old friend Rhiannon, she is startled; Rhiannon disappeared years ago without a trace. But Lenna is even more startled to learn that Rhiannon has a son and that she lives off the grid with a group of women in a community called Halcyon. Rhiannon invites Lenna, a new mother herself, to join them. Why suffer the sleepless nights by yourself? It takes a village, after all. Lenna decides to go and hopefully repair her relationship with Rhiannon, but as she drives into the desert and her cell service gets weaker, she becomes suspicious.

Haiwen is buying bananas at a 99 Ranch Market in Los Angeles when he looks up and sees Suchi, his Suchi, for the first time in sixty years. To recently widowed Haiwen it feels like a second chance, but Suchi has only survived by refusing to look back. Suchi was seven when she first met Haiwen in their Shanghai neighborhood, drawn by the sound of his violin. Their childhood friendship blossomed into soul-deep love, but when Haiwen secretly enlisted in the Nationalist army in 1947 to save his brother from the draft, she was left with just his violin and a note: Forgive me.

July 1962. Following in the tradition of Indigenous workers from Nova Scotia, a Mi’kmaq family arrives in Maine to pick blueberries for the summer. Weeks later, four-year-old Ruthie, the family’s youngest child, vanishes. She is last seen by her six-year-old brother, Joe, sitting on a favorite rock at the edge of a berry field. Joe will remain distraught by his sister’s disappearance for years to come.

When ten-year-old Ebby Freeman heard the gunshot, time stopped. And when she saw her brother, Baz, lying on the floor surrounded by the shattered pieces of a centuries-old jar, life as Ebby knew it shattered as well. The crime was never solved—and because the Freemans were one of the only Black families in a particularly well-to-do enclave of New England—the case has had an enduring, voyeuristic pull for the public. The last thing the Freemans want is another media frenzy splashing their family across the papers, but when Ebby's high profile romance falls apart, that's exactly what they get.

Cece is in love. She has arrived early at her in-laws’ beautiful lake house in Salish, Montana, to finish planning her wedding to Charlie, a medical student with a brilliant future. Charlie asks Garrett, his best friend from college, to officiate, though Cece can’t imagine anyone less appropriate for the task; Garrett doesn’t believe in love, much less marriage. But as she spends time with Garrett, and his gruff mask slips, her long-held expectations for her life with Charlie begin to crumble, her feelings for Garrett—haunted by a tragic event from his past—become impossible to bury.