Early one morning in 1929, Mary Seneca Steele spontaneously packs a suitcase, gathers up her son and daughter, and drives away in her abusive and dissolute husband’s brand-new Auburn Phaeton automobile, leaving her privileged life in Charleston behind. It is the beginning of a journey of enlightenment that leads Mary “Sen” to the mountains and mysteries of Appalachia, where she will learn unexpected family secrets, create a new life for herself and her children, and finally experience love and happiness before tragedy will once again test her.

Alice Hunter is smarting from the raw deal life has thrown her way: suddenly single, jobless and forced to move home to her parents' tiny seaside town. And now she faces an uncomfortable truth. She wants her twin sister Libby's enviable life. Libby's closest friend Jess Dekic has been around the Hunter family for so long she might as well be blood. She's always considered herself a sister closer to Libby than Alice ever could be.

On the last day of eighth grade, Maggie begins to dream of finding a way to escape the drudgery and confinement of life in the hollow and establish her independence. Her plan begins to fall in place when she enters high school and discovers she has a natural talent for excelling in shorthand, typing, and other business classes. Meanwhile she spares no effort in helping her family continue to survive despite their poverty, a less than fertile few acres, and a family history of instability.

Generations of Sassers have made moonshine in the Brushy Mountains of Wilkes County, North Carolina. Their history is recorded in a leather-bound journal that belongs to Jessie Sasser's daddy, but Jessie wants no part of it. As far as she's concerned, moonshine caused her mother's death a dozen years ago. Her father refuses to speak about her mama, or about the day she died. But Jessie has a gnawing hunger for the truth - one that compels her to seek comfort in food.

When 15-year-old Marigold becomes pregnant amid the Great Depression, she is rejected by her family and forced to fend for herself. And when she loses her baby in the forest, her whole world turns upside down. She’s even more distraught upon discovering she has an inexplicable power that makes her both beautiful and terrifying - and something of a local legend. Meanwhile, migrant workers Vern and Paul discover a violet-eyed baby and take it upon themselves to care for her.

Set in the mountains of southern Appalachia, Demon Copperhead is the story of a boy born to a teenaged single mother in a single-wide trailer, with no assets beyond his dead father’s good looks and copper-colored hair, a caustic wit, and a fierce talent for survival. Relayed in his own unsparing voice, Demon braves the modern perils of foster care, child labor, derelict schools, athletic success, addiction, disastrous loves, and crushing losses.

The folks in the Kentucky Appalachians are scraping by. Coal mining and hardscrabble know-how are a way of life for these isolated people. But when Amanda Rye, a young widowed mother and traveling packhorse librarian, comes through a mountain community hit hard by the nation’s economic collapse, she brings with her hope, courage, and apple pie.

During the Great Depression, labor camps crop up in remote areas throughout the American South. Destitute workers live under terrible conditions. Trapped in these isolated locations, workers are entirely dependent on the often greedy, abusive camp owners who provide food and housing at grossly inflated prices. But for the most desperate among America's vast unemployed, these camps are often the last and only option.

Grace Bradshaw knows the exact minute she will die. On death row for murdering her infant son, her last breath will be taken on February 15 at 12:01 a.m. Eleven years, five months, and 27 days separate her from the last time she heard her precious daughter's voice and the final moment she'd heard anyone call her mom. Out of appeals, she can focus on only one thing - reconnecting with her daughter and making sure she knows the truth.

It's 1924 in Branchville, South Carolina, and three women have come to a crossroads. Gertrude, a mother of four, must make an unconscionable decision to save her daughters. Retta, a first-generation freed slave, comes to Gertrude's aid by watching her children, despite the gossip it causes in her community. Annie, the matriarch of the influential Coles family, offers Gertrude employment at her sewing circle, while facing problems of her own at home.

London, 2017: When Aurelia Leclaire inherits an opulent Paris apartment, she is shocked to discover her grandmother’s hidden secrets - including a treasure trove of famous art and couture gowns. One obscure painting leads her to Gabriel Seymour, a highly respected art restorer with his own mysterious past. Together they attempt to uncover the truths concealed within the apartment’s walls.

Mary Roberts is an impoverished child living in a council flat in 1950s London. When she and her sister are left at an orphanage by their mother, they don't think their lives can get any worse. Harry Evans is an orphan who finds himself, with Mary and her sister, on board a ship bound for Australia. They're sent to a farm school for children, where abuse and neglect are rife. A journey that will change their lives forever and from which they’ll never return.

Rita and Rosie Stevens are only nine and five years old when their widowed mother marries a violent bully called Jimmy Randall and has a baby boy by him. Under pressure from her new husband, she is persuaded to send the girls to an orphanage, not knowing that the papers she has signed will entitle them to do what they like with the children. And it is not long before the powers that be decide to send a consignment of orphans to their sister institution in Australia. Among them - without their family's consent or knowledge - are Rita and Rosie.

Mollie Sheehan has spent much of her life striving to be a dutiful daughter and honor her father's wishes, even when doing so has led to one heartbreak after another. After all, what options does she truly have in 1860s Montana? But providing for her stepfamily during her father's long absences doesn't keep her from wishing for more. When romance blooms between her and Peter Ronan, Mollie finally allows herself to hope for a brighter future—until her father voices his disapproval of the match and moves her to California to ensure the breakup. Still, time and providence are at work.

For years, the town of Silver Bell, Arkansas has quietly mourned the hospital fire that claimed the lives of nine of its residents—the town doctor, a young expectant mother, and seven infants. So, when journalist Finn Hardwick is assigned the story as part of a national thirtieth anniversary memorial service, he arrives at the town ready to interview its residents, thinking they’ll be ready to share and eager to make headlines. He isn’t prepared for the resistance. Or for what appears to be a collective unwillingness to answer his questions.

In a North Carolina mountain town filled with moonshine and rotten husbands, Sadie Blue is only the latest girl to face a dead-end future at the mercy of a dangerous drunk. She's been married to Roy Tupkin for 15 days, and she knows now that she should have listened to the folks who said he was trouble. But when a stranger sweeps in and knocks the world off-kilter for everyone in town, Sadie begins to think there might be more to life than being Roy's wife.

Deep in the tobacco land of North Carolina, nothing's been the same since the boys shipped off to war and worry took their place. Thirteen-year-old Lucy Brown is precocious and itching for adventure. Then Allie Bert Tucker wanders into town, an outcast with a puzzling past, and Lucy figures the two of them can solve any curious crime they find - just like her hero, Nancy Drew. Their chance comes when a man goes missing, a woman stops speaking, and an eccentric gives the girls a mystery to solve that takes them beyond the ordinary.

During the Great Depression, labor camps crop up in remote areas throughout the American South. Destitute workers live under terrible conditions. Trapped in these isolated locations, workers are entirely dependent on the often greedy, abusive camp owners who provide food and housing at grossly inflated prices. But for the most desperate among America's vast unemployed, these camps are often the last and only option.

For 14-year-old Wallis Ann Stamper and her family, life in the Appalachian Mountains is simple and satisfying, though not for the tenderhearted. While her older sister, Laci - a mute, musically gifted savant - is constantly watched over and protected, Wallis Ann is as practical and sturdy as her name. When the Tuckasegee River bursts its banks, forcing them to flee in the middle of the night, those qualities save her life. But though her family is eventually reunited, the tragedy opens Wallis Ann's eyes to a world beyond the creek that's borne their name for generations.

Generations of Sassers have made moonshine in the Brushy Mountains of Wilkes County, North Carolina. Their history is recorded in a leather-bound journal that belongs to Jessie Sasser's daddy, but Jessie wants no part of it. As far as she's concerned, moonshine caused her mother's death a dozen years ago. Her father refuses to speak about her mama, or about the day she died. But Jessie has a gnawing hunger for the truth - one that compels her to seek comfort in food.

"The dead can't hurt you. Only the living can." Effie Jones, a former slave who escaped to the Union side as a child, knows the truth of her words. Taken in by an army surgeon and his wife during the War, she learned to read and write, to tolerate the sight of blood and broken bodies - and to forget what is too painful to bear. Now a young freedwoman, she has returned south to New Orleans and earns her living as an embalmer, her steady hand and skillful incisions compensating for her white employer's shortcomings.

In the South Carolina Hills, along the Savannah River Watershed, in the fall of 1829, 14-year-old, three-quarter Cherokee Sahani, whose Christian name is Charity, sets out on a journey with her 83-year-old white grandfather to Fort Charlotte for what she thinks is a trip to trade the pelts he has accumulated in order to replenish their supplies. However, Charity soon discovers that her grandfather's objective in making this trip is to get her married off and settled somewhere.

In 1969 Dixie Dupree is 11 years old and already an expert liar. Sometimes the lies are for her mama Evie's sake - to explain away a bruise brought on by her quick-as-lightning temper. And sometimes the lies are to spite Evie, who longs to leave her unhappy marriage in Perry County, Alabama, and return to her beloved New Hampshire. But for Dixie and her brother, Alabama is home, a place of pine-scented breezes and hot, languid afternoons.

Eleven-year-old Grace Carter has a talent for hiding things. She's had plenty of practice, burying thoughts and feelings that might anger her strict evangelical pastor father. The Knowing, as Grace calls it, offers glimpses of people's pasts and futures. It enables her to see into the depth of her mother's sadness, and even allows Grace to talk to Isaac, her twin brother who died at birth. To her wise, loving Aunt Pearl, the Knowing is a family gift; to her daddy, it's close to witchcraft.

In the fall of 1918, 13-year-old German immigrant Pia Lange longs to be far from Philadelphia's overcrowded streets and slums, and from the anti-German sentiment that compelled her father to enlist in the US Army, hoping to prove his loyalty. But an even more urgent threat has arrived. Spanish influenza is spreading through the city. Soon, dead and dying are everywhere. With no food at home, Pia must venture out in search of supplies, leaving her infant twin brothers alone....

Ten years ago, Izzy Stone's mother fatally shot her father while he slept. Devastated by her mother's apparent insanity, Izzy, now 17, refuses to visit her in prison. But her new foster parents, employees at the local museum, have enlisted Izzy's help in cataloguing items at a long-shuttered state asylum. There, amid piles of abandoned belongings, Izzy discovers a stack of unopened letters, a decades-old journal, and a window into her own past.

In 18th-century Spitalfields, London, Esther Thorel, wife of a master silk weaver, rescues Sara Kemp from a brothel. She thinks she is doing God's will, but her good deed is not returned. Sara quickly realizes that the Thorel household is built on hypocrisy and lies and soon tires of the drudgery of life as Esther's new lady's maid. As the two women's relationship becomes increasingly fractious, Sara resolves to find out what it is that so preoccupies her mistress.

Sage Winters always knew her sister was a little different even though they were identical twins. They loved the same things and shared a deep understanding, but Rosemary—awake to every emotion, easily moved to joy or tears—seemed to need more protection from the world. Six years after Rosemary's death from pneumonia, Sage, now sixteen, still misses her deeply. Their mother perished in a car crash, and Sage's stepfather, Alan, resents being burdened by a responsibility he never wanted.

In the wake of the police shooting of a black teenager, Los Angeles is as tense as it’s been since the unrest of the early 1990s. But Grace Park and Shawn Matthews have their own problems. Grace is sheltered and largely oblivious, living in the Valley with her Korean-immigrant parents, working long hours at the family pharmacy. She’s distraught that her sister hasn’t spoken to their mother in two years, for reasons beyond Grace’s understanding.

Three generations of the Brown women travel west together on the Oregon Trail, but each seeks something different. When the trail divides, a decision must be made that could bring survival or tragedy. The challenges faced will form the character of one woman - and impact the future for many more.