In a North Carolina mountain town filled with moonshine and rotten husbands, Sadie Blue is only the latest girl to face a dead-end future at the mercy of a dangerous drunk. She's been married to Roy Tupkin for 15 days, and she knows now that she should have listened to the folks who said he was trouble. But when a stranger sweeps in and knocks the world off-kilter for everyone in town, Sadie begins to think there might be more to life than being Roy's wife.

For 14-year-old Wallis Ann Stamper and her family, life in the Appalachian Mountains is simple and satisfying, though not for the tenderhearted. While her older sister, Laci - a mute, musically gifted savant - is constantly watched over and protected, Wallis Ann is as practical and sturdy as her name. When the Tuckasegee River bursts its banks, forcing them to flee in the middle of the night, those qualities save her life. But though her family is eventually reunited, the tragedy opens Wallis Ann's eyes to a world beyond the creek that's borne their name for generations.

During the Great Depression, labor camps crop up in remote areas throughout the American South. Destitute workers live under terrible conditions. Trapped in these isolated locations, workers are entirely dependent on the often greedy, abusive camp owners who provide food and housing at grossly inflated prices. But for the most desperate among America's vast unemployed, these camps are often the last and only option.

Deep in the tobacco land of North Carolina, nothing's been the same since the boys shipped off to war and worry took their place. Thirteen-year-old Lucy Brown is precocious and itching for adventure. Then Allie Bert Tucker wanders into town, an outcast with a puzzling past, and Lucy figures the two of them can solve any curious crime they find - just like her hero, Nancy Drew. Their chance comes when a man goes missing, a woman stops speaking, and an eccentric gives the girls a mystery to solve that takes them beyond the ordinary.

Generations of Sassers have made moonshine in the Brushy Mountains of Wilkes County, North Carolina. Their history is recorded in a leather-bound journal that belongs to Jessie Sasser's daddy, but Jessie wants no part of it. As far as she's concerned, moonshine caused her mother's death a dozen years ago. Her father refuses to speak about her mama, or about the day she died. But Jessie has a gnawing hunger for the truth - one that compels her to seek comfort in food.

On the last day of eighth grade, Maggie begins to dream of finding a way to escape the drudgery and confinement of life in the hollow and establish her independence. Her plan begins to fall in place when she enters high school and discovers she has a natural talent for excelling in shorthand, typing, and other business classes. Meanwhile she spares no effort in helping her family continue to survive despite their poverty, a less than fertile few acres, and a family history of instability.

In the South Carolina Hills, along the Savannah River Watershed, in the fall of 1829, 14-year-old, three-quarter Cherokee Sahani, whose Christian name is Charity, sets out on a journey with her 83-year-old white grandfather to Fort Charlotte for what she thinks is a trip to trade the pelts he has accumulated in order to replenish their supplies. However, Charity soon discovers that her grandfather's objective in making this trip is to get her married off and settled somewhere.

In the fall of 1918, 13-year-old German immigrant Pia Lange longs to be far from Philadelphia's overcrowded streets and slums, and from the anti-German sentiment that compelled her father to enlist in the US Army, hoping to prove his loyalty. But an even more urgent threat has arrived. Spanish influenza is spreading through the city. Soon, dead and dying are everywhere. With no food at home, Pia must venture out in search of supplies, leaving her infant twin brothers alone....

"The dead can't hurt you. Only the living can." Effie Jones, a former slave who escaped to the Union side as a child, knows the truth of her words. Taken in by an army surgeon and his wife during the War, she learned to read and write, to tolerate the sight of blood and broken bodies - and to forget what is too painful to bear. Now a young freedwoman, she has returned south to New Orleans and earns her living as an embalmer, her steady hand and skillful incisions compensating for her white employer's shortcomings.

In 1969 Dixie Dupree is 11 years old and already an expert liar. Sometimes the lies are for her mama Evie's sake - to explain away a bruise brought on by her quick-as-lightning temper. And sometimes the lies are to spite Evie, who longs to leave her unhappy marriage in Perry County, Alabama, and return to her beloved New Hampshire. But for Dixie and her brother, Alabama is home, a place of pine-scented breezes and hot, languid afternoons.

Sage Winters always knew her sister was a little different even though they were identical twins. They loved the same things and shared a deep understanding, but Rosemary—awake to every emotion, easily moved to joy or tears—seemed to need more protection from the world. Six years after Rosemary's death from pneumonia, Sage, now sixteen, still misses her deeply. Their mother perished in a car crash, and Sage's stepfather, Alan, resents being burdened by a responsibility he never wanted.

On a summer evening in 1931, Lilly Blackwood glimpses circus lights from the grimy window of her attic bedroom. Lilly isn't allowed to explore the meadows around Blackwood Manor. She's never even ventured beyond her narrow room. Momma insists it's for Lilly's own protection, that people would be afraid if they saw her. But on this unforgettable night, Lilly is taken outside for the first time - and sold to the circus sideshow.

Eliza Spalding Warren was just a child when she was taken hostage by the Cayuse Indians during a massacre in 1847. Now the young mother of two children, Eliza faces a different kind of dislocation; her impulsive husband wants them to make a new start in another territory, which will mean leaving her beloved home and her departed mother's grave - and returning to the land of her captivity.

Although Jessilyn and Gemma’s friendship has weathered the storms of heartache and prejudice, the turbulent summer of 1936 threatens to shatter the ties that bind. After the hit-and-run death of a little girl, Gemma’s explosive revelation could save an innocent man’s life—but not without jeopardizing the livelihood of Jessilyn’s family.

Young Julie Harmon works "hard as a man", they say, so hard that at times she's not sure she can stop. People depend on her to slaughter the hogs and nurse the dying. People are weak, and there is so much to do. At just 17 she marries and moves down into the valley of Gap Creek, where perhaps life will be better. But Julie and Hank's new life in the valley, in the last years of the 19th century, is more complicated than the couple ever imagined.