For 14-year-old Wallis Ann Stamper and her family, life in the Appalachian Mountains is simple and satisfying, though not for the tenderhearted. While her older sister, Laci - a mute, musically gifted savant - is constantly watched over and protected, Wallis Ann is as practical and sturdy as her name. When the Tuckasegee River bursts its banks, forcing them to flee in the middle of the night, those qualities save her life. But though her family is eventually reunited, the tragedy opens Wallis Ann's eyes to a world beyond the creek that's borne their name for generations.

During the Great Depression, labor camps crop up in remote areas throughout the American South. Destitute workers live under terrible conditions. Trapped in these isolated locations, workers are entirely dependent on the often greedy, abusive camp owners who provide food and housing at grossly inflated prices. But for the most desperate among America's vast unemployed, these camps are often the last and only option.

In 1969 Dixie Dupree is 11 years old and already an expert liar. Sometimes the lies are for her mama Evie's sake - to explain away a bruise brought on by her quick-as-lightning temper. And sometimes the lies are to spite Evie, who longs to leave her unhappy marriage in Perry County, Alabama, and return to her beloved New Hampshire. But for Dixie and her brother, Alabama is home, a place of pine-scented breezes and hot, languid afternoons.

In a North Carolina mountain town filled with moonshine and rotten husbands, Sadie Blue is only the latest girl to face a dead-end future at the mercy of a dangerous drunk. She's been married to Roy Tupkin for 15 days, and she knows now that she should have listened to the folks who said he was trouble. But when a stranger sweeps in and knocks the world off-kilter for everyone in town, Sadie begins to think there might be more to life than being Roy's wife.

Deep in the tobacco land of North Carolina, nothing's been the same since the boys shipped off to war and worry took their place. Thirteen-year-old Lucy Brown is precocious and itching for adventure. Then Allie Bert Tucker wanders into town, an outcast with a puzzling past, and Lucy figures the two of them can solve any curious crime they find - just like her hero, Nancy Drew. Their chance comes when a man goes missing, a woman stops speaking, and an eccentric gives the girls a mystery to solve that takes them beyond the ordinary.

Growing up on their hardscrabble farm in rural Kentucky, 15-year-old Albertina "Bertie" Winslow has learned a lot from her mama, Polly. She knows how to lance a boil, make a pie crust, butcher a pig, and tend to every chore that needs doing. What she doesn't know, but is forced to reckon with all too soon, is how to look after children as a mother should. When Polly succumbs to a long illness, Bertie takes on responsibility for her four younger siblings and their dissolute, unreliable daddy.

On the last day of eighth grade, Maggie begins to dream of finding a way to escape the drudgery and confinement of life in the hollow and establish her independence. Her plan begins to fall in place when she enters high school and discovers she has a natural talent for excelling in shorthand, typing, and other business classes. Meanwhile she spares no effort in helping her family continue to survive despite their poverty, a less than fertile few acres, and a family history of instability.

Ten years ago, Izzy Stone's mother fatally shot her father while he slept. Devastated by her mother's apparent insanity, Izzy, now 17, refuses to visit her in prison. But her new foster parents, employees at the local museum, have enlisted Izzy's help in cataloguing items at a long-shuttered state asylum. There, amid piles of abandoned belongings, Izzy discovers a stack of unopened letters, a decades-old journal, and a window into her own past.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

In the fall of 1918, 13-year-old German immigrant Pia Lange longs to be far from Philadelphia's overcrowded streets and slums, and from the anti-German sentiment that compelled her father to enlist in the US Army, hoping to prove his loyalty. But an even more urgent threat has arrived. Spanish influenza is spreading through the city. Soon, dead and dying are everywhere. With no food at home, Pia must venture out in search of supplies, leaving her infant twin brothers alone....

Sage Winters always knew her sister was a little different even though they were identical twins. They loved the same things and shared a deep understanding, but Rosemary—awake to every emotion, easily moved to joy or tears—seemed to need more protection from the world. Six years after Rosemary's death from pneumonia, Sage, now sixteen, still misses her deeply. Their mother perished in a car crash, and Sage's stepfather, Alan, resents being burdened by a responsibility he never wanted.

"The dead can't hurt you. Only the living can." Effie Jones, a former slave who escaped to the Union side as a child, knows the truth of her words. Taken in by an army surgeon and his wife during the War, she learned to read and write, to tolerate the sight of blood and broken bodies - and to forget what is too painful to bear. Now a young freedwoman, she has returned south to New Orleans and earns her living as an embalmer, her steady hand and skillful incisions compensating for her white employer's shortcomings.

Eliza Spalding Warren was just a child when she was taken hostage by the Cayuse Indians during a massacre in 1847. Now the young mother of two children, Eliza faces a different kind of dislocation; her impulsive husband wants them to make a new start in another territory, which will mean leaving her beloved home and her departed mother's grave - and returning to the land of her captivity.

For twelve-year-old Martha "Sonny" Creech, there is no place more beautiful than her family's cotton farm. She, her two brothers, and her parents work hard on their land - hoeing, planting, picking - but only Sonny loves the rich, dark earth the way her father does. When a tragic accident claims his life, her stricken family struggles to fend off ruin - until their rich, reclusive neighbor offers to help finance that year's cotton crop.

The year 1900 ushers in a new century and the promise of social change, and women rise together toward equality. Yet rules and restrictions remain, especially for women like Alice Butterworth, whose husband has abruptly disappeared. Constance Halstead, a young widow, has thrown herself into charitable work. Meeting Alice at the orphanage, she offers lodging in exchange for Alice's help creating a gown for the Leap Year ball of Les Mystérieuses, the first all-female krewe of Mardi Gras. Piece by piece, the breathtaking gown takes shape, becoming a symbol of strength for both women.