Transcribed from the original lectures recorded at San Francisco State University in 1987, The Nature of Drugs series highlights Shulgin’s engaging lecture style peppered with illuminating anecdotes and amusing asides. Ostensibly taught as an introductory course on drugs and biochemistry, these books serve as both a historical record of Shulgin’s teaching style and the culmination of his philosophy on drugs, psychopharmacology, states of consciousness, and societal and individual freedoms pertaining to their use, both medicinal and exploratory.

The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.

In 1518, in a small town in Alsace, Frau Troffea began dancing and didn't stop. She danced until she was carried away six days later, and soon 34 more villagers joined her. Then more. In a month more than 400 people had been stricken by the mysterious dancing plague. In late-19th-century England an eccentric gentleman founded the No Nose Club in his gracious townhome - a social club for those who had lost their noses, and other body parts, to the plague of syphilis for which there was then no cure.

When a small vial arrives in her mailbox from "Lewis Carroll", Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Blood carries life, yet the sight of it makes people faint. It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquitousness, the few tablespoons of blood discharged by 800 million women are still regarded as taboo: menstruation is perhaps the single most demonized biological event.

Guns, germs, and steel might have transformed us from hunter-gatherers into modern man, but booze, sex, trash talk, and tripping built our civilization. Cracked editor Robert Evans brings his signature dogged research and lively insight to uncover the many and magnificent ways vice has influenced history, from the prostitute-turned-empress who scored a major victory for women's rights to the beer that helped create - and destroy - South America's first empire.

As director of the world's largest abortion clinic and the nation's most prominent abortionist, Dr. Bernard Nathanson presided over 60,000 abortions. As co-founder of the National Abortion Rights Action League, he helped make abortion legal. Then, in a conversion that made headkines and astonished both sides of the abortion debate, he renounced his profession to become a pro-life advocate. But Dr. Nathanson's journey was not over.

A Perfect Red recounts the colorful history of cochineal, a legendary red dye that was once one of the world's most precious commodities. Treasured by the ancient Mexicans, cochineal was sold in the great Aztec marketplaces, where it attracted the attention of the Spanish conquistadors in 1519. Shipped to Europe, the dye created a sensation, producing the brightest, strongest red the world had ever seen. Soon Spain's cochineal monopoly was worth a fortune. Desperate to find their own sources of the elusive dye, the English, French, Dutch, and other Europeans tried to crack the enigma of cochineal.

Am I happy enough? This has been a pivotal question since America's inception. "Am I not happy enough because I am depressed?" is a more recent version. Psychotherapist Gary Greenberg shows how depression has been manufactured---not as an illness but as an idea about our suffering, its source, and its relief. He challenges us to look at depression in a new way.

David Oshinsky, whose last book, Polio: An American Story, was awarded a Pulitzer Prize, chronicles the history of America's oldest hospital and in so doing also charts the rise of New York to the nation's preeminent city, the path of American medicine from butchery and quackery to a professional and scientific endeavor, and the growth of a civic institution.

The Nazi regime preached an ideology of physical, mental, and moral purity. But as Norman Ohler reveals in this gripping new history, the Third Reich was saturated with drugs. On the eve of World War II, Germany was a pharmaceutical powerhouse, and companies such as Merck and Bayer cooked up cocaine, opiates, and, most of all, methamphetamines, to be consumed by everyone from factory workers to housewives to millions of German soldiers.

As one of the most potent turning points in the country's modern history, the Opium War has since come to stand for everything that today's China seeks to put behind it. In this dramatic, epic story, award-winning historian Stephen Platt sheds new light on the early attempts by Western traders and missionaries to "open" China even as China's imperial rulers were struggling to manage their country's decline and Confucian scholars grappled with how to use foreign trade to China's advantage.

A Vermeer painting shows a military officer in a Dutch sitting room, talking to a laughing girl. In another canvas, fruit spills from a blue-and-white porcelain bowl. Familiar images that captivate us with their beauty--but as Timothy Brook shows us, these intimate pictures actually give us a remarkable view of an expanding world.

In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus travelled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test. As socially significant as both world wars, the Spanish flu dramatically disrupted - and often permanently altered - global politics, race relations, and family structures while spurring innovation in medicine, religion, and the arts.

Known to mankind since prehistoric times, opium is arguably the oldest and most widely used narcotic. Opium: A History traces the drug's astounding impact on world culture - from its religious use by prehistoric peoples to its influence on the imaginations of the Romantic writers; from the earliest medical science to the Sino-British opium wars.

Opium tells the extraordinary and at times harrowing tale of how we arrived at today's crisis, "mak[ing] timely and startling connections among painkillers, politics, finance, and society" (Laurence Bergreen). The story begins with the discovery of poppy artifacts in ancient Mesopotamia, and goes on to explore how Greek physicians and obscure chemists discovered opium's effects and refined its power, how colonial empires marketed it around the world, and eventually how international drug companies developed a range of powerful synthetic opioids that led to an addiction epidemic.

Tobacco was first cultivated and enjoyed by the indigenous inhabitants of the Americas, who used it for medicinal, religious, and social purposes long before the arrival of Columbus. But when Europeans began to colonize the American continents, it became something else entirely - a cultural touchstone of pleasure and success and a coveted commodity that would transform the world economy forever.

Poppy tears, opium, heroin, fentanyl: humankind has been in thrall to the ‘Milk of Paradise’ for millennia. The latex of papaver somniferum is a bringer of sleep, of pleasurable lethargy, of relief from pain - and hugely addictive. A commodity without rival, it is renewable, easy to extract, transport and refine, and subject to an insatiable global demand. No other substance in the world is as simple to produce or as profitable. It is the basis of a gargantuan industry built upon a shady underworld, but ultimately it is a farm-gate material that lives many lives ....

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Past antidrug campaigns actually encouraged drug use. A few years ago, America stopped dropping acid altogether. The meth epidemic peaked a long, long time ago. NAFTA opened the border and created a bonanza for cocaine and meth traffickers just as President Clinton knew it would. President Reagan may have inadvertently caused the crack epidemic. Kids today are doing fewer illegal drugs than kids from any time in the recent past, and for a surprising reason.

What won't we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine - yes, that strychnine, the one used in rat poison - was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices.

In The Book of Gin, Richard Barnett traces the life of this beguiling spirit, once believed to cause a new kind of drunkenness. In the 18th century, gin-craze debauchery (and class conflict) inspired Hogarth's satirical masterpieces "Gin Lane" and "Beer Street". In the 19th century, gin was drunk by Napoleonic War naval heroes, at lavish gin palaces, and by homesick colonials, who mixed it with their bitter anti-malarial tonics.

A revealing biography of Dr. Benjamin Rush - fiery signer of the Declaration of Independence, prominent physician, ardent politician, zealous social reformer, passionate humanitarian, and dedicated educator. Known primarily as America's most influential and leading physician, Rush was also among the first to call for the abolition of slavery, equal rights for women, free education and health care for the poor, slum clearance, citywide sanitation facilities, an end to child labor, and universal public education, among other causes.

Ancient China collides with newfangled America in this epic tale of opium smugglers, sea pirates, and dueling clipper ships. Brilliantly illuminating one of the least-understood areas of American history, best-selling author Eric Jay Dolin now traces our fraught relationship with China back to its roots: the unforgiving nineteenth-century seas that separated a brash, rising naval power from a battered ancient empire. It is a prescient fable for our time, one that surprisingly continues to shed light on our modern relationship with China.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

David Oshinsky, whose last book, Polio: An American Story, was awarded a Pulitzer Prize, chronicles the history of America's oldest hospital and in so doing also charts the rise of New York to the nation's preeminent city, the path of American medicine from butchery and quackery to a professional and scientific endeavor, and the growth of a civic institution.

The Nazi regime preached an ideology of physical, mental, and moral purity. But as Norman Ohler reveals in this gripping new history, the Third Reich was saturated with drugs. On the eve of World War II, Germany was a pharmaceutical powerhouse, and companies such as Merck and Bayer cooked up cocaine, opiates, and, most of all, methamphetamines, to be consumed by everyone from factory workers to housewives to millions of German soldiers.

In An American Plague, Jim Murphy tells the story of the 1793 yellow fever epidemic. Bizarre medical practices of the time are discussed, as well as popular historical figures, such as George Washington and Benjamin Rush, who were involved in finding a cure for this horrific outbreak. Pat Bottino's captivating narration adds appeal to this interesting historical tale.

In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus travelled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test. As socially significant as both world wars, the Spanish flu dramatically disrupted - and often permanently altered - global politics, race relations, and family structures while spurring innovation in medicine, religion, and the arts.