When a private plane whisks CDC epidemiologist Madeline Hamilton to Washington, DC, for an urgent medical symposium, she knows something significant is underway - but she doesn’t expect to face the most disturbing medical mystery of her career. A debilitating neurological toxin has stricken the children of several political families, and one of them is the son of US President Anna Moreland.

After his December 2003 arrest, registered nurse Charlie Cullen was quickly dubbed "The Angel of Death" by the media. But Cullen was no mercy killer, nor was he a simple monster. He was a favorite son, husband, beloved father, best friend, and celebrated caregiver. Implicated in the deaths of as many as 300 patients, he was also perhaps the most prolific serial killer in American history.

Avery Keene, a brilliant young law clerk for the legendary Justice Howard Wynn, is doing her best to hold her life together - excelling in an arduous job with the court while also dealing with a troubled family. When the shocking news breaks that Justice Wynn - the cantankerous swing vote on many current high-profile cases - has slipped into a coma, Avery’s life turns upside down. She is immediately notified that Justice Wynn has left instructions for her to serve as his legal guardian and power of attorney.

Mickey Gibson, single mother and former detective, leads a hectic life similar to that of many moms: juggling the demands of her two small children with the tasks of her job working remotely for ProEye, a global investigation company that hunts down wealthy tax and credit cheats. When Mickey gets a call from a colleague named Arlene Robinson, she thinks nothing of Arlene’s unusual request for her to go inventory the vacant home of an arms dealer who cheated ProEye’s clients and fled.

A cop lies dying beneath the blistering Arizona sun - a local lawman who may well have become the next sheriff of Cochise County. The police brass claim that Andy Brady was dirty, and that his shooting was a suicide attempt. Joanna Brady, his devoted wife and mother of their nine-year-old daughter, knows a cover-up when she hears one...and murder when she sees it.

FBI Special Agent Nina Guerrera escaped a serial killer’s trap at 16. Years later, when she’s jumped in a Virginia park, a video of the attack goes viral. Legions of new fans are not the only ones impressed with her fighting skills. The man who abducted her 11 years ago is watching. Determined to reclaim his lost prize, he commits a grisly murder designed to pull her into the investigation...but his games are just beginning. And he’s using the internet to invite the public to play along.

Terence Bailey is about to be released from prison for breaking and entering, though investigators have long suspected him in the murders of six women. As his release date approaches, Bailey gets a surprise visit from Maddison Logan, a hot, young influencer with a huge social media following. Hours later, Maddison disappears, and police suspect she’s been kidnapped—or worse. Is Maddison’s disappearance connected to her visit to Bailey? And why was she visiting him in the first place?

Eric Swan can be killed - but he can never die. For a government agent hunting the most dangerous domestic terrorists, that comes in handy. But Swan is beginning to question his own humanity. Is technology turning this Q2 secret agent into a monster himself? Now villainous brother-sister twins, fueled by a lust for power and revenge, have set their sights on taking down the power grid. And they’ve hired an army of mercenaries to protect them.

Tech millionaire Miles Cookson has more money than he can ever spend and everything he could dream of - except time. He has recently been diagnosed with a terminal illness, and there is a 50 percent chance that it can be passed on to the next generation. For Miles, this means taking a long hard look at his past. Two decades ago, a young, struggling Miles was a sperm donor. Somewhere out there, he has kids - nine of them. And they might be about to inherit both the good and the bad from him - maybe his fortune, or maybe something much worse.

After a late night of partying, NYU student Matt Pine returns to his dorm room to devastating news: nearly his entire family - his mom, his dad, his little brother and sister - have been found dead from an apparent gas leak while vacationing in Mexico. The local police claim it was an accident, but the FBI and State Department seem far less certain - and they won’t tell Matt why.

For San Francisco’s newest medical examiner, Dr. Jessie Teska, it was supposed to be a fresh start. A new job in a new city. A way to escape her own dark past. Instead, she faces a chilling discovery when an opioid-overdose case contains hints of something more sinister. Jessie’s superiors urge her to close the case, but as more bodies land on her autopsy table, she uncovers a constellation of deaths that point to an elaborate plot involving drug dealers and Bitcoin brokers.

When a teenager from a wealthy suburb outside Oakland is dumped at an inner city bus stop, homicide detective Matt Sinclair catches the case. It's his first since being bumped to desk duty for a bust that went south - fast. With few leads and plenty of attention, it's the worst kind of case to help him get back up to speed. And it only gets worse as the bodies start to pile up - first at the same bus bench, then around the city. Sinclair is unable to link the victims to each other, and the killer is just getting started.

When a local girl falls prey to a sadistic serial killer, Nashville homicide lieutenant Taylor Jackson and her lover, FBI profiler Dr. John Baldwin, find themselves in a joint investigation pursuing a vicious murderer. The Southern Strangler is slaughtering his way through the Southeast, leaving a gruesome memento at each crime scene – the prior victim’s severed hand.

Juan Gutierrez, a cancer researcher, uncovers what he believes to be the key to conquering humanity's susceptibility to cancer. But others are interested in using the new genetic algorithm for very different applications. Nate Carrington, an FBI forensic analyst, has been struggling with several cold cases when he's alerted to an incident at a nearby ranch. It's a case of a newborn calf who is found in the middle of a herd of dead cattle. It provides a single link to Nate's other cold cases....

Three years ago, a collision between a fast-moving freight train and a school bus full of kids led to devastation and grief on an unimaginable scale. But a fresh clue leads San Antonio police detective Amara Alvarez to the unlikely conclusion that one of the children may still be alive. If she's correct, everything law enforcement believes about the accident is a lie.