With The Interruption of Everything, her sixth novel, Terry McMillan takes on the fault lines of mid-life and family life, reminds us once again of the redeeming power of friendship, and turns her eye toward the dilemma of how a woman starts to put her own needs higher on the to-do list while not shortchanging everyone else.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

After 27 years of marriage and three children, Anna Oh - wife, mother, outsider artist - has fallen in love with Viveca, the wealthy Manhattan art dealer who orchestrated her success. They plan to wed in the Oh family’s hometown of Three Rivers in Connecticut. But the wedding provokes some very mixed reactions and opens a Pandora’s Box of toxic secrets - dark and painful truths that have festered below the surface of the Ohs' lives.

Marnie MacGraw wants an ordinary life - a husband, kids, and a minivan in the suburbs. Now that she’s marrying the man of her dreams, she’s sure this is the life she’ll get. Then Marnie meets Blix Holliday, her fiancé’s irascible matchmaking great-aunt who’s dying, and everything changes - just as Blix told her it would. When her marriage ends after two miserable weeks, Marnie is understandably shocked.

After grad school, Shay Dixon feels like she's had enough for awhile. Inspired by her spiritual adviser - a soul-soothing blues player named Nina Simon - Shay calls her estranged mother Nona for the first time in years, and shocks herself by asking if it would be okay to come home for a while.

From marriage, infidelity, and the mayhem of motherhood to scandal, tragedy, and illness - three women seek peace and comfort in Nantucket as they cope with life's challenges. Three women - burdened with small children, unwieldy straw hats, and some obvious emotional issues - tumble onto the Nantucket airport tarmac one hot June day. Vicki is trying to sort through the news that she has a serious illness. Her sister, Brenda, has just left her job after being caught in an affair with a student. And their friend Melanie, after seven failed in vitro attempts, is pregnant at last.

Allison Weiss is a typical working mother, trying to balance a business, aging parents, a demanding daughter, and a marriage. But when the website she develops takes off, she finds herself challenged to the point of being completely overwhelmed. Her husband’s becoming distant, her daughter’s acting spoiled, her father is dealing with early Alzheimer’s, and her mother’s barely dealing at all.

Leah Thornton’s life, like her Southern Living home, has great curb appeal. But a paralyzing encounter with a can of frozen apple juice in the supermarket shatters the façade, forcing her to admit that all is not as it appears. When her best friend gets in Leah’s face about her refusal to deal with her life and her drinking, Leah is forced to make a decision. Can this brand-conscious socialite walk away from the country club into 28 days of rehab?

At the age of 29, Hannah Martin still has no idea what she wants to do with her life. She has lived in six different cities and held countless meaningless jobs since graduating college. On the heels of leaving yet another city, Hannah moves back to her hometown of Los Angeles and takes up residence in her best friend Gabby’s guestroom. Shortly after getting back to town, Hannah goes out to a bar one night with Gabby and meets up with her high school boyfriend, Ethan. Just after midnight, Gabby asks Hannah if she’s ready to go. A moment later, Ethan offers to give her a ride.

Carmen got the jeans at a thrift shop. They didn't look all that great; they were worn, dirty, and speckled with bleach. On the night before she and her friends part for the summer, Carmen decides to toss them. But Tibby says they're great. She'd love to have them. Lena and Bridget also think they're fabulous. Lena decides they should all try them on. Whoever they fit best will get them. Nobody knows why, but the pants fit everyone perfectly.

Cannie Shapiro never wanted to be famous. The smart, sharp, plus-sized pop culture reporter was perfectly content writitng about other people's lives in the pages of the Philadlphia Examiner. But the day she opened up a national women's magazine to find out that her ex-boyfriend has been chronicling their ex-sex life is the day her life changes forever.

Filled with wit and heart, Get Lucky by Katherine Center explores the deep bonds of sisterhood. Sarah Harper’s whole world revolved around her job at a New York advertising agency before an email snafu got her fired. Now she’s seeking refuge at her sister Mackie’s home in Houston. But Mackie, who’s unable to get pregnant, is also down-and-out these days. So Sarah decides to do something good and becomes a surrogate mother.

A self-anointed spinster at 51, Myra Lipinski is reasonably content with her quiet life, her dog, Frank, and her career as a visiting nurse. But everything changes when Chip Reardon, the golden boy she adored in high school, is assigned as her new patient. Choosing to forgo treatment for an incurable illness, Chip has returned to his New England hometown to spend what time he has left. Now, Myra and Chip find themselves engaged in a poignant redefinition of roles, and a complicated dance of memory, ambivalence, and longing.

Jonathan and Rosie have been together so long they finish each other's sentences - so when he (finally) proposes and asks her to move across the country with him, everyone is happily surprised. But when things suddenly unravel, Rosie sends Jonathan packing and moves back home with Soapie, the irascible, opinionated grandmother who raised her.

Maggie Baxter, a practical, rule-following accountant, discovers that her husband of 17 years is cheating on her. All her meticulous life plans are crushed. When he leaves her for the other woman, Maggie and her the-world-is-my-smorgasbord chocolate lab, Kona, are left to put their lives back together. As Maggie begins to develop a Plan B for her life, she decides to be more like Kona. No, she's not going to sniff crotches and eat everything that isn't nailed down; rather she'll try to approach life with more ball-chasing abandon.