Joy and Annie are friends and roommates whose thirty-something lives aren’t exactly what they’d imagined. To make ends meet, they decide to rent their extra bedroom to Theo, who charms Joy with his salt-and-pepper hair and adoration of their one-eyed cat. When Annie goes to live with her boyfriend, Theo and Joy settle into a comfortable domesticity. Then Theo brings home Celine, the girlfriend he’s never mentioned, who is possibly the most stunning woman Joy has ever seen. Joy resolves to do whatever it takes to hold on to him, falling deeper into a hellscape of her own making.

A woman arrives alone at a Best Western seeking respite from an emptiness that plagues her. She has fled to the California high desert to escape a cloud of sorrow—for both her father in the ICU and a husband whose illness is worsening. What the motel provides, however, is not peace but a path discovered on a nearby hike. Out along the sun-scorched trail, the narrator encounters a towering cactus whose size and shape mean it should not exist in California. Yet the cactus is there, with a gash through its side that beckons like a familiar door.

Irina obsessively takes explicit photographs of the average-looking men she persuades to model for her, scouted from the streets of Newcastle. Placed on sabbatical from her dead-end bar job, she is offered an exhibition at a fashionable London gallery, promising to revive her career in the art world and offering an escape from her rut of drugs, alcohol and extreme cinema. The news triggers a self-destructive tailspin, centred around Irina's relationship with her obsessive best friend and a shy young man from her local supermarket who has attracted her attention....

Widower Mukesh lives a quiet life in the London Borough of Ealing after losing his beloved wife. He shops every Wednesday, goes to Temple, and worries about his granddaughter, Priya, who hides in her room reading. Aleisha is a bright but anxious teenager working at the local library when she discovers a crumpled-up piece of paper. It's a list of novels that she's never heard of before. When Mukesh arrives at the library, desperate to forge a connection with his bookworm granddaughter, Aleisha passes along the reading list…hoping that it will be a lifeline for him too.

Grieving mother Magos cuts out a piece of her deceased eleven-year-old son Santiago's lung. Acting on fierce maternal instinct and the dubious logic of an old folktale, she nurtures the lung until it gains sentience, growing into the carnivorous little Monstrilio she keeps hidden within the walls of her family's decaying Mexico City estate. Eventually, Monstrilio begins to resemble the Santiago he once was, but his innate impulses—though curbed by his biological and chosen family's communal care—threaten to destroy this fragile second chance at life.