The Antidote
Inside the World of New Pharma
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Narrated by:
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Sean Pratt
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By:
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Barry Werth
About this listen
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325-billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It is riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, The Antidote is a powerful inside look at one of the most intriguing and important business stories of recent decades.
©2014 Barry Werth (P)2014 TantorListeners also enjoyed...
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- Length: 6 hrs and 19 mins
- Unabridged
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Overall
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Performance
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Story
Open provides valuable lessons in leadership in times of crisis, management decision-making under the pressure of extraordinary growth, and the power of a unique, pervasive culture. Open tells the incredible story of Compaq’s meteoric rise from humble beginnings to become the PC industry leader in just over a decade. Along the way, Compaq helped change the face of computing while establishing the foundation for today’s world of tablets and smart phones.
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Wrong narrator for this book
- By Wick Smith on 07-13-14
By: Rod Canion
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The Firm
- The Story of McKinsey and Its Secret Influence on American Business
- By: Duff McDonald
- Narrated by: Tom Weiner
- Length: 11 hrs and 19 mins
- Unabridged
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Overall
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Performance
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Story
A behind-the-scenes, revelatory history of McKinsey & Company, America's most influential and controversial business consulting firm, told by one of the nation's leading financial journalists. In The Firm, Duff McDonald uncovers how these high-powered, high-priced business savants have ushered in waves of structural, financial, and technological shifts. With unrivaled access to company documents and current and former employees, McDonald reveals the inner workings of what just might be the most influential private organization in America.
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Warning: Non consultants should avoid
- By R. Jaeger on 11-04-13
By: Duff McDonald
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Overhaul
- An Insider's Account of the Obama Administration's Emergency Rescue of the Auto Industry
- By: Steven Rattner
- Narrated by: Joe Barrett
- Length: 13 hrs and 28 mins
- Unabridged
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Overall
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Performance
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Story
This first real look inside Team Obama mixes political warfare and big-business shakeups in equal proportions, and comes from a uniquely informed source. Steve Rattner is not just the man brought in by the president to save the auto industry, he is a former New York Times financial reporter who also earned a place among the top tier of Wall Street's most informed investment bankers and corporate experts.
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Overhaul - A Memoir
- By Roy on 12-05-10
By: Steven Rattner
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Who Says Elephants Can't Dance?
- Inside IBM's Historic Turnaround
- By: Louis V. Gerstner Jr.
- Narrated by: Edward Herrmann
- Length: 8 hrs and 29 mins
- Unabridged
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Overall
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Performance
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Story
In 1990, IBM had its most profitable year ever. By 1993, the company was on a watch list for extinction, victimized by its own lumbering size, an insular corporate culture, and the PC era IBM had itself helped invent.
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Moderate Start, Picks up FAST!
- By Art H on 02-08-05
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Epic Measures
- One Doctor. Seven Billion Patients.
- By: Jeremy N. Smith
- Narrated by: Patrick Lawlor
- Length: 10 hrs and 12 mins
- Unabridged
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Overall
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Performance
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Story
Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time - the groundbreaking program to answer the most essential question for humanity: How do we live and die? - and the visionary mastermind behind it.
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Fabulously insightful read!
- By Dr. Jack E. Fincham on 10-08-15
By: Jeremy N. Smith
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Good for the Money
- My Fight to Pay Back America
- By: Bob Benmosche
- Narrated by: Sean Pratt
- Length: 9 hrs and 33 mins
- Unabridged
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Overall
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Performance
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Story
In 2009, at the peak of the financial crisis, AIG - the American insurance behemoth - was sinking fast. It was the peg upon which the nation hung its ire and resentment during the financial crisis: the pinnacle of Wall Street arrogance and greed. When Bob Benmosche climbed aboard as CEO, it was widely assumed that he would go down with his ship. In mere months, he turned things around, pulling AIG from the brink of financial collapse and restoring its profitability.
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Worthwhile, informative, and just short of inspiring
- By Preston on 11-17-21
By: Bob Benmosche
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Silent Invasion
- The Untold Story of the Trump Administration, Covid-19, and Preventing the Next Pandemic Before It's Too Late
- By: Deborah Birx
- Narrated by: Kathe Mazur
- Length: 22 hrs and 3 mins
- Unabridged
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Overall
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Performance
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Story
In late February 2020, Dr. Deborah Birx—a lifelong federal health official who had worked at the CDC, the State Department, and the US Army across multiple presidential administrations—was asked to join the Trump White House Coronavirus Task Force and assist the already faltering federal response to the Covid-19 pandemic. For weeks, she’d been raising the alarm behind the scenes about what she saw happening in public—from the apparent lack of urgency at the White House to the routine downplaying of the risks to Americans.
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Great insight into Public Health
- By Ann-Karen Weller on 05-09-22
By: Deborah Birx
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No Better Time
- The Brief, Remarkable Life of Danny Lewin, the Genius Who Transformed the Internet
- By: Molly Knight Raskin
- Narrated by: Christine Marshall
- Length: 6 hrs and 22 mins
- Unabridged
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Overall
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Performance
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Story
No Better Time tells of a young, driven mathematical genius who wrote a set of algorithms that would create a faster, better Internet. It's the story of a beautiful friendship between a loud, irreverent student and his soft-spoken MIT professor, of a husband and father who spent years struggling to make ends meet only to become a billionaire almost overnight with the success of Akamai Technologies, the Internet content delivery network he cofounded with his mentor.
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An Overlooked Hero of 9-11
- By Jean on 05-27-16
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A Bigger Prize
- How We Can Do Better Than the Competition
- By: Margaret Heffernan
- Narrated by: Margaret Heffernan
- Length: 15 hrs and 48 mins
- Unabridged
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Overall
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Performance
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Story
From the cranberry bogs of Massachusetts to the classrooms of Singapore and Finland, from tiny start-ups to global engineering firms and beloved American organizations like Ocean Spray, Eileen Fisher, Gore, and Boston Scientific, Heffernan discovers ways of living and working that foster creativity, spark innovation, reinforce our social fabric, and feel so much better than winning.
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Margaret Heffernan is brilliant!
- By Eric Willingham on 06-09-16
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Good to Great
- Why Some Companies Make the Leap...And Others Don't
- By: Jim Collins
- Narrated by: Jim Collins
- Length: 10 hrs and 1 min
- Unabridged
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Overall
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Performance
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Story
Built To Last, the defining management study of the 90s, showed how great companies triumph over time and how long-term sustained performance can be engineered into the DNA of an enterprise from the very beginning. But what about companies that are not born with great DNA? How can good companies, mediocre companies, even bad companies achieve enduring greatness?
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Good info, over-the-top narration
- By Anaxamaxan on 08-31-10
By: Jim Collins
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Finish Big
- How Great Entrepreneurs Exit Their Companies on Top
- By: Bo Burlingham
- Narrated by: Sean Pratt
- Length: 10 hrs and 17 mins
- Unabridged
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Overall
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Performance
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Story
When pioneering business journalist and Inc. magazine editor at large Bo Burlingham wrote Small Giants, it became an instant classic for its original take on a common business problem - how to handle the pressure to grow. Now Burlingham is back to tackle an even more common problem - how to exit your company well. Sooner or later, all entrepreneurs leave their businesses and all businesses get sold, given away, or liquidated.
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Begin with the end in mind
- By D. Hartzell on 02-05-15
By: Bo Burlingham
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Data-ism
- The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else
- By: Steve Lohr
- Narrated by: Steve Lohr
- Length: 6 hrs and 33 mins
- Unabridged
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Overall
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Performance
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Story
Coal, iron ore, and oil were the key productive assets that fueled the Industrial Revolution. Today data is the vital raw material of the information economy. The explosive abundance of this digital asset, more than doubling every two years, is creating a new world of opportunity and challenge. Data-ism is about this next phase, in which vast, Internet-scale data sets are used for discovery and prediction in virtually every field. It is a journey across this emerging world with people, illuminating narrative examples, and insights.
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More business case than serious analysis
- By Godfried Gubbels on 06-03-15
By: Steve Lohr
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What listeners say about The Antidote
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Michael Bigger
- 10-28-16
Creating Societal Value
Enjoyed listening to the inside stories about the challenges of creating life enhancing products for humanity. A+
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- Paul Gerard
- 06-27-15
Development of elegant new medicine
The author brings us inside the finance and science of the development of an entirely new concept in medicine. Vertex looks at chronic illness at the mechanism and focuses on fixing the problem rather than the symptoms. This is the 21st century in health care.
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- Yan
- 06-26-17
For me this was not interesting
Sorry for the harsh commentary.... It's like someone compiled all of their stock market announcements into a book, flavored with some irrelevant details about the employees... I was hoping to hear some insights about the pharma market. The book started well.
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1 person found this helpful