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The Genesis Machine
- Our Quest to Rewrite Life in the Age of Synthetic Biology
- Narrated by: Amy Webb, Andrew Hessel, Tim Campbell, Landon Woodson, Amanda Dolan
- Length: 10 hrs and 6 mins
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Publisher's summary
What if the miracle that created mRNA vaccines is less a once-in-lifetime event and more the harbinger of the emerging age of synthetic biology? This fusion of biology and computers has a singular goal: to gain access to cells in order to write new—and possibly better—biological code.
Synthetic biology promises to reveal how life is created and how it can be re-created, enabling scientists to rewrite the rules of our reality. It could help us, for example, heal without prescription medications, grow meat without harvesting animals, or confront our looming climate catastrophe. Synthetic biology will determine the ways in which we conceive future generations and how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. Soon, we will program living, biological structures as though they were tiny computers.
But who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.
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Just general advice on how to survive
- By A. Yoshida on 09-01-17
By: Joi Ito, and others
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Resilience
- Why Things Bounce Back
- By: Andrew Zolli, Ann Marie Healy
- Narrated by: Sean Runnette
- Length: 11 hrs and 8 mins
- Unabridged
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Katrina. Haiti. BP. Fukushima. The Great Recession. Those are just a few of the catastrophic disruptions the world has endured in recent years. As we try to respond to such crises, key questions arise: What causes one system to break under great stress and another to rebound? How much change can a complex system absorb while still retaining its purpose and function? What characteristics make it adaptive to change? Provocative and eye-opening, Resilience sheds light on the nature of change.
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Totally Misleading Title
- By Doug on 07-18-12
By: Andrew Zolli, and others
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Creation
- How Science Is Reinventing Life Itself
- By: Adam Rutherford
- Narrated by: Walter Dixon
- Length: 6 hrs and 53 mins
- Unabridged
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What is life? Humans have been asking this question for thousands of years. But as technology has advanced and our understanding of biology has deepened, the answer has evolved. For decades, scientists have been exploring the limits of nature by modifying and manipulating DNA, cells, and whole organisms to create new ones that could never have previously existed on their own.
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The Goldilocks book on what is life
- By Gary on 07-11-13
By: Adam Rutherford
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Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- By: Richard Harris
- Narrated by: Joe Delafield
- Length: 5 hrs and 56 mins
- Unabridged
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American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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Eye opening introduction to biomedical R&D
- By Amazon Customer on 09-18-18
By: Richard Harris
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Know This
- Today's Most Interesting and Important Scientific Ideas, Discoveries, and Developments
- By: John Brockman
- Narrated by: Gabra Zackman, Dan John Miller
- Length: 14 hrs and 39 mins
- Unabridged
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Scientific developments radically alter our understanding of the world. Whether it's technology, climate change, health research, or the latest revelations of neuroscience, physics, or psychology, science has, as Edge editor John Brockman says, "become a big story, if not the big story". In that spirit this new addition to Edge.org's fascinating series asks a powerful and provocative question: What do you consider the most interesting and important recent scientific news?
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Pete and Repeat and Re-repeat
- By Daniel L on 02-25-18
By: John Brockman
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Influenza
- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
- By: Dr. Jeremy Brown
- Narrated by: Holter Graham
- Length: 6 hrs and 28 mins
- Unabridged
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On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
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Important read
- By Kathryn C. on 12-21-18
By: Dr. Jeremy Brown
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Poison Spring
- The Secret History of Pollution and the EPA
- By: E. G. Vallianatos, McKay Jenkins
- Narrated by: Michael McConnahie
- Length: 9 hrs and 47 mins
- Unabridged
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Imagine walking into a restaurant and finding chlorinated hydrocarbon pesticides, or neonicotinoid insecticides listed in the description of your entree. They may not be printed in the menu, but many are in your food.These are a few of the literally millions of pounds of approved synthetic substances dumped into the environment every day, not just in the US but around the world.
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A Frightening Wake Up Call!
- By Exec. Chef 'Special K' on 07-02-14
By: E. G. Vallianatos, and others
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p53: The Gene That Cracked the Cancer Code
- By: Sue Armstrong
- Narrated by: Elizabeth Jasicki
- Length: 9 hrs and 55 mins
- Unabridged
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p53: The Gene That Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys, and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
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Excellent story! Unfortunate narration at start
- By Adriana on 12-25-14
By: Sue Armstrong
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The Secret History of the War on Cancer
- By: Devra Davis Ph.D.
- Narrated by: Pam Ward
- Length: 19 hrs and 11 mins
- Unabridged
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The War on Cancer was run by leaders of industries that made cancer-causing products and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies, a legacy that persists to this day.
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Silly Book
- By Adam Smith on 12-24-14
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Jump-Starting America
- How Breakthrough Science Can Revive Economic Growth and the American Dream
- By: Jonathan Gruber, Simon Johnson
- Narrated by: Robert Fass
- Length: 9 hrs and 57 mins
- Unabridged
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The untold story of how America once created the most successful economy the world has ever seen and how we can do it again.
By: Jonathan Gruber, and others
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Data-ism
- The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else
- By: Steve Lohr
- Narrated by: Steve Lohr
- Length: 6 hrs and 33 mins
- Unabridged
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Coal, iron ore, and oil were the key productive assets that fueled the Industrial Revolution. Today data is the vital raw material of the information economy. The explosive abundance of this digital asset, more than doubling every two years, is creating a new world of opportunity and challenge. Data-ism is about this next phase, in which vast, Internet-scale data sets are used for discovery and prediction in virtually every field. It is a journey across this emerging world with people, illuminating narrative examples, and insights.
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More business case than serious analysis
- By Godfried Gubbels on 06-03-15
By: Steve Lohr
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The Big Nine
- How the Tech Titans and Their Thinking Machines Could Warp Humanity
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In this book, Amy Webb reveals the pervasive, invisible ways in which the foundations of AI - the people working on the system, their motivations, the technology itself - is broken. Within our lifetimes, AI will, by design, begin to behave unpredictably, thinking and acting in ways which defy human logic. The big nine corporations may be inadvertently building and enabling vast arrays of intelligent systems that don't share our motivations, desires, or hopes for the future of humanity.
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How do you tell a real trend from the merely trendy? How, for example, will a technology—like artificial intelligence, machine learning, self-driving cars, biohacking, bots, and the Internet of Things—affect us, our businesses, and workplaces? How will it eventually change the way we live, work, play, and think—and how should we prepare for it now? In The Signals Are Talking, noted futurist Amy Webb shows us how to analyze the "true signals" and land on the right side of disruption.
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Good book, awful narrator
- By Chelsea on 08-09-18
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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Inception
- The Genesis Machine, Book 1
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When expert Navy linguist and cryptographer Charlie Cutter is recruited into a shadowy wing of the NCIS, she's tasked with unraveling a mysterious ancient text that has puzzled researchers for centuries. Charlie isn't eager to revisit her previous failures... but when she discovers the same strange language in top-secret photographs, she finds herself roped into a job that could make or break her young career.
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Realistic modern day search for alien life.
- By Barnmaster on 04-20-24
By: K.J. Gillenwater
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Superconvergence
- How the Genetics, Biotech, and AI Revolutions Will Transform our Lives, Work, and World
- By: Jamie Metzl
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Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.
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Great Book Somewhat Spoiled by Self-Promotion
- By Jack E. Koepke on 06-22-24
By: Jamie Metzl
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Hacking the Code of Life
- How Gene Editing Will Rewrite Our Futures
- By: Nessa Carey
- Narrated by: Karen Cass
- Length: 4 hrs and 41 mins
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Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.
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Decent Overview. Could lose sarcasm.
- By A. Toomey on 06-18-20
By: Nessa Carey
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The Big Nine
- How the Tech Titans and Their Thinking Machines Could Warp Humanity
- By: Amy Webb
- Narrated by: Amanda Dolan
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Performance
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In this book, Amy Webb reveals the pervasive, invisible ways in which the foundations of AI - the people working on the system, their motivations, the technology itself - is broken. Within our lifetimes, AI will, by design, begin to behave unpredictably, thinking and acting in ways which defy human logic. The big nine corporations may be inadvertently building and enabling vast arrays of intelligent systems that don't share our motivations, desires, or hopes for the future of humanity.
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Interesting but Frustrating
- By Kathy on 03-26-19
By: Amy Webb
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The Signals Are Talking
- By: Amy Webb
- Narrated by: Tiffany Morgan
- Length: 10 hrs and 28 mins
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Overall
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Performance
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How do you tell a real trend from the merely trendy? How, for example, will a technology—like artificial intelligence, machine learning, self-driving cars, biohacking, bots, and the Internet of Things—affect us, our businesses, and workplaces? How will it eventually change the way we live, work, play, and think—and how should we prepare for it now? In The Signals Are Talking, noted futurist Amy Webb shows us how to analyze the "true signals" and land on the right side of disruption.
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Good book, awful narrator
- By Chelsea on 08-09-18
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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Inception
- The Genesis Machine, Book 1
- By: K.J. Gillenwater
- Narrated by: Jennifer Jill Araya
- Length: 5 hrs and 33 mins
- Unabridged
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Overall
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Performance
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When expert Navy linguist and cryptographer Charlie Cutter is recruited into a shadowy wing of the NCIS, she's tasked with unraveling a mysterious ancient text that has puzzled researchers for centuries. Charlie isn't eager to revisit her previous failures... but when she discovers the same strange language in top-secret photographs, she finds herself roped into a job that could make or break her young career.
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Realistic modern day search for alien life.
- By Barnmaster on 04-20-24
By: K.J. Gillenwater
-
Superconvergence
- How the Genetics, Biotech, and AI Revolutions Will Transform our Lives, Work, and World
- By: Jamie Metzl
- Narrated by: James Anderson Foster, Jamie Metzl
- Length: 15 hrs and 44 mins
- Unabridged
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Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.
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Great Book Somewhat Spoiled by Self-Promotion
- By Jack E. Koepke on 06-22-24
By: Jamie Metzl
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Hacking the Code of Life
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Just 45 years ago, the age of gene modification was born. Researchers could create glow-in-the-dark mice, farmyard animals producing drugs in their milk, and vitamin-enhanced rice that could prevent half a million people going blind every year. But now GM is rapidly being supplanted by a new system called CRISPR or "gene editing". Using this approach, scientists can manipulate the genes of almost any organism with a degree of precision, ease and speed that we could only dream of ten years ago.
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Decent Overview. Could lose sarcasm.
- By A. Toomey on 06-18-20
By: Nessa Carey
What listeners say about The Genesis Machine
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- John D. Furber
- 04-16-22
Mostly accurate, worthwhile, informative
A comprehensive exploration of this important field. The authors got most of the facts right. The readers were good, easy to listen to. Only mispronounced a few technical terms. But if you have to choose only one, I recommend "The Code Breaker" by Walter Isaacson, about CRISPR and Jennifer Doudna.
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1 person found this helpful
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- J
- 02-21-22
Great book on the possibilities of the future of Human biology
Preordered this a few months back because I’ve enjoy the previous works of Amy Webb. I’m in the tech industry but haven’t had any exposure to biological sciences since college about 10 years ago. The scenarios laid out may seem outlandish but if you see the real world examples cited throughout the book then they begin to seem plausible and realistic. The narrator did a great job and definitely recommend anyone to take a listen to it if they’re willing to have an open mind.
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2 people found this helpful
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- Rupert
- 04-17-22
Frightening
Evolution continues while some contemplates if it's true. There are the applications of so many methods within our universe yet we continue to think of God as a magician.
Thank you Amy and Andrew. And let's hail the TWIT audience, heard about this there.
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- Brian Garrett
- 05-17-22
The future is going to be crazy
Definitely lots of very interesting vectors the biological future is going to be taking. I'm hoping that some of the items they are working on are going to have a direct benefit to my longevity, but I'm afraid it's going to happen slightly slower than I want it to. Of course the darker side of this is the "dark science" that could be used in a negative way on humanity. Definitely a good read IMHO.
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1 person found this helpful
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- Rockin' Horse
- 03-11-22
A Warning
This book contains science surveyed without an agenda. It can be scary to hear facts
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1 person found this helpful
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- Andy
- 07-02-22
Thought provoking but politically biased
Very thought provoking and worth reading. The text lacks some level of detail to support its claims but does offer some broad brush speculations. Readers should be aware of obvious left wing political bias throughout the text, painting a less than balanced picture of events as well as obviously biased views of potential futures.
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7 people found this helpful
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- Austin
- 05-24-22
Really good synthesis of the field with an informed perspective; bad solutions
The first 90% of the book was really great! Really informative history including even recent advancements in synthetic biology. The last 10% with their solutions leave a lot to be desired. They softly peddle the “COVID was a made in a Chinese lab” conspiracy to argue against gain-of-function research. That left a really bad taste in my mouth. Their other “solutions” were a bit oversimplistic.
However, the first 90% of the book, especially the scenarios toward the end, make it worth it.
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2 people found this helpful
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- Jim
- 03-26-22
Very Enlightening
I'm not well versed in the topic of synthetic biology so I found this book to be very informative. A lot of the concepts about DNA as property and potentially as a technology for things I'd never even considered. it's given me a new perspective and a lot of stuff to think about.
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1 person found this helpful
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- J. T. Holmes
- 01-10-23
Excellent overview of synthetic biology
Thoroughly enjoyed this overview of synthetic biology. The narration was excellent. We are clearly heading into unknown territory with all of the advances in cellular biology research. It is up to all of us to participate to ensure a positive outcome.
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- India Carlson
- 02-25-23
required for anyone interested in the future of biology
a balanced review of the history of synthetic biology that gives both positive and negatives of possibilities facing humanity and recommendations for making policy to guide the world
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