Our brains are the most complex machines known to humankind, but they have an Achilles heel: The very molecules that allow us to exist can also sabotage our minds. Here are true accounts of unruly molecules and the diseases that form in their wake, from total loss of inhibitions to florid psychosis to compulsive lying.

With compassionate stories of his patients and their conditions, Dr. Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest that will not only maintain our physical and mental health, but improve our cognitive abilities and overall happiness.

Carl Zimmer investigates one of the biggest questions of all: What is life? The answer seems obvious until you try to seriously answer it. Is the apple sitting on your kitchen counter alive, or is only the apple tree it came from deserving of the word? If we can’t answer that question here on Earth, how will we know when and if we discover alien life on other worlds? The question hangs over some of society’s most charged conflicts - whether a fertilized egg is a living person, for example, and when we ought to declare a person legally dead.

Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals, and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin and tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom, A Taste for Poison leads listeners on a fascinating tour of the intricate, complex systems that keep us alive - or don’t.

Robert Sapolsky’s Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but that doesn’t mean it doesn’t exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and in his inimitable way, delightful) full-frontal assault on the pleasant fantasy that there is some separate self telling our biology what to do.

Oliver Sacks' The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with fantastic perceptual and intellectual aberrations: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; who are stricken with violent tics and grimaces or who shout involuntary obscenities; whose limbs have become alien; who have been dismissed as retarded yet are gifted with uncanny artistic or mathematical talents.

You make hundreds of decisions every day, from what to eat for breakfast to how you should invest, and not one of them could be made without the essential component of emotion. It has long been held that thinking and feeling are separate and opposing forces in our behavior. But as Leonard Mlodinow, the best-selling author of Subliminal, tells us, extraordinary advances in psychology and neuroscience have proven that emotions are as critical to our well-being as is rational thinking.

Hallucinations don’t belong wholly to the insane. Much more commonly, they are linked to sensory deprivation, intoxication, illness, or injury. Here Dr. Sacks weaves together stories of his patients and of his own mind-altering experiences to illuminate what hallucinations tell us about the organization and structure of our brains, how they have influenced every culture’s folklore and art, and why the potential for hallucination is present in us all.

How would Saturn’s rings look from a spaceship sailing just above them? If you were falling into a black hole, what’s the last thing you’d see before your spaghettification? What would it be like to visit the faraway places we currently experience only through high-powered telescopes and robotic emissaries? Faster-than-light travel may never be invented, but we can still take the scenic route through the universe with renowned astronomer and science communicator Philip Plait.

A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier.

A prize-winning journalist with a background in neuroscience, Helen Thomson spent years tracking down people who live with the world's most extraordinary neurological disorders - like a man who tried to break his back because his legs no longer felt like his own, and another who believed that he was dead for nine years. Not content to simply read about these cases on paper, Thomson reached out to 10 people with these afflictions, and they agreed to tell her their stories.

In the tradition of Oliver Sacks, a tour of the latest neuroscience of schizophrenia, autism, Alzheimer’s disease, ecstatic epilepsy, Cotard’s syndrome, out-of-body experiences, and other disorders - revealing the awesome power of the human sense of self from a master of science journalism. Anil Ananthaswamy’s extensive in-depth interviews venture into the lives of individuals who offer perspectives that will change how you think about who you are.

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

A puzzling series of dental explosions beginning in the 19th century is just one of many strange tales that have long lain undiscovered in the pages of old medical journals. Award-winning medical historian Thomas Morris delivers one of the most remarkable, cringe-inducing collections of stories ever assembled.

Dr. Jonathan Reisman - a physician, adventure traveler, and naturalist - brings listeners on an odyssey, navigating our insides like an explorer discovering a new world. With unique insight, Reisman shows us how understanding mountain watersheds helps to diagnose heart attacks, how the body is made mostly of mucus, not water, and how urine carries within it a tale of humanity’s origins.