Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

From her silver Mercedes to her designer kitchen, Molly's life is gleaming and beautiful - at least on the surface. Married to Tanner, a top cosmetic dentist, she has a wonderful daughter finishing high school and twin stepsons from Tanner's first marriage. No one in her exclusive neighborhood in Goldenhills, Massachusetts, knows what living with the demanding Tanner is really like. They know even less about the life she left behind in Florida almost two decades ago.

For generations, the Windsors have lived on the family's grand estate in Crestwood, South Carolina, as intertwined with local life as sweet tea and pecan pie. Now, on the anniversary of her daughter Emily's death, Sarabess Windsor believes she may be the last to carry the family name - unless she can find her second daughter, Trinity, who disappeared 15 years ago.

As far as former NFL star Jake Masters is concerned, dreams are risky propositions. Years ago he came achingly close to achieving his ambition of playing in the Super Bowl - before a spinal injury ended his career. Confined to a wheelchair, unwilling to take a chance on another risky surgery that could restore his mobility, Jake now stays cocooned behind the imposing gates of his lavish home.

Raised in a magnificent Charleston house, Jessie Roland wants for nothing. But as she grows into young adulthood, all she feels is loss and a desperate need to break free from the stifling possessiveness of her parents. Somewhere, in the deepest part of herself, Jessie believes that the world she has always lived in is not the one she came from...or belongs in. Now, at 19, she has escaped to Washington, DC, where no one knows her, and where she is swept into a whirlwind marriage to a Texas senator's son.

Olivia Lowell always believed her father's claim that her mother died in childbirth, until the shocking day a lawyer informs her that her mother has just passed away, leaving her a fortune. The money comes with a caveat - and a confession. In her will, Olivia's mother reveals that she and two college friends committed a crime long ago, and now she wants Olivia to track down her accomplices and convince them to come clean.

At 17, Rosalind “Lin” Townsend finds herself pregnant and alone. Her father, deeply religious yet cruel, throws her out of the house. Nick Pemberton, her baby’s father and the man she naively hoped might marry her, rejects her. Yet even at the lowest point in her life, Lin vows to succeed on her own terms, and to give her son, Will, all the love and happiness she’s been denied.

At 29, Alison Marshall is ready to find a place to call home. With no family and no ties, she’s drifted from one small Florida town to another since high school, working odd jobs, saving hard, and building a nest egg. Once she finds the right place to settle down, she’ll know. And when she reaches beautiful Palmetto Island, she thinks she may have found it. The small, close-knit island community seems to have everything Alison needs. On a hunch, she contacts the island’s only realtor, and learns that an old beach house is on the market.

After years of standing by their women, the Sisterhood's significant others have also become loyal friends. And now Jack Emery, Nikki's husband, has enlisted Ted, Joe, Jay, Bert, Dennis, and Abner to form a top-secret organization known as BOLO Consultants.

With a heart full of dreams, Sallie Coleman leaves Texas and heads west determined to get as far from the squalor of her dirt poor beginnings. With its shifting sands, smoky saloons, and bingo palaces, Las Vegas seems like a paradise. A paradise where an extraordinary twist of fate makes Sallie the most powerful businesswoman in Nevada.

Luna Bodman always looks forward to a new shipment of furniture at the restoration shop. Her brother, Cullen, has a knack for finding discarded pieces with an intriguing history, and Luna likes to sit with each item to see if she can feel any kind of vibrations. Usually, Cullen does his thing while Luna does hers, but the arrival of an old armoire triggers a reaction in Luna that’s impossible to ignore. From the moment Luna wiggles inside the armoire and closes her eyes, she feels an overpowering and disturbing sensation.

If her abusive husband hadn't tried to kill her and her beloved dog Lucie, Helen Ward might never have left her million-dollar home and run far away. Now Helen's changed her identity and moved across the country, hopeful that she can be safe, happy, maybe even loved. And when she meets college professor Sam Tolliver, she begins to believe fairytales do come true.

Gus Hollister owes all his success to his feisty grandmother, Rose, and he knows it. It was Rose and her two sisters, Iris and Violet, who raised Gus, sent him to the best schools, and helped him start his own accounting business. Rose even bought the house Gus lives in with his wife, Elaine. But now, Gus stands to lose everything - his home, his car, and his business. Worse, he’s alienated his beloved grandma, who tried to warn him about Elaine’s greedy, gold-digging ways.

Kate and Alex Rocket are blessed with a wonderful marriage and a lovely home. Although Kate is unable to bear children, she and Alex look upon Sara and Emily, affectionate daughters of their good friends Don and Debbie Winter, as part of their family. With one phone call, everything changes. Sara accuses Alex of a heinous act, opening up a vicious rift between the couples. In a single moment an idyllic all-American life has imploded into an unfathomable nightmare. Kate can only watch helplessly as her innocent husband is convicted and sent to prison.