Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity’s uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality.

According to the accepted narrative of progress, humans have thrived thanks to their brains and brawn, collectively bending the arc of history. But in this revelatory book, Professor Jonathan Kennedy argues that the myth of human exceptionalism overstates the role that we play in social and political change. Instead, it is the humble microbe that wins wars and topples empires.

What won't we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine - yes, that strychnine, the one used in rat poison - was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices.

In The End Is Always Near, Dan Carlin looks at questions and historical events that force us to consider what sounds like fantasy; that we might suffer the same fate that all previous eras did. Will our world ever become a ruin for future archaeologists to dig up and explore? The questions themselves are both philosophical and like something out of The Twilight Zone.

Most stories of medical progress come with ready-made heroes. John Snow traced the origins of London's 1854 cholera outbreak to a water pump, leading to the birth of epidemiology. Florence Nightingale's contributions to the care of soldiers in the Crimean War transformed hospitals from crucibles of infection to sanctuaries of recuperation. Yet histories of individual innovators ignore many key sources of medical knowledge.

Cities and countries engulfed by panic and death, desperate for vaccines but fearful of what inoculation may bring. This is what the world has just gone through with Covid-19. But as Simon Schama shows in his epic history of vulnerable humanity caught between the terror of contagion and the ingenuity of science, it has happened before.

You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.

As a University of Chicago–trained economist and Harvard medical school professor and doctor, Anupam Jena is uniquely equipped to answer these questions. And as a critical care doctor at Massachusetts General who researches health care policy, Christopher Worsham confronts their impact on the hospital’s sickest patients. In this singular work of science and medicine, Jena and Worsham show us how medicine really works, and its effect on all of us.

In Jared Diamond’s follow-up to the Pulitzer-Prize winning Guns, Germs and Steel, the author explores how climate change, the population explosion, and political discord create the conditions for the collapse of civilization. Environmental damage, climate change, globalization, rapid population growth, and unwise political choices were all factors in the demise of societies around the world, but some found solutions and persisted.

Twenty-five years ago, Neil Howe and the late William Strauss dazzled the world with a provocative new theory of American history. Looking back at the last 500 years, they’d uncovered a distinct pattern: modern history moves in cycles, each one lasting roughly 80 to 100 years, the length of a long human life, with each cycle composed of four eras—or “turnings”—that always arrive in the same order and each last about 25 years. The last of these eras—the fourth turning—was always the most perilous, a period of civic upheaval and national mobilization.

As a Yale School of Medicine physician, the New York Times best-selling author of Every Patient Tells a Story, and an inspiration and adviser for the hit Fox TV drama, House, M.D., Lisa Sanders has seen it all. And yet, she is often confounded by the cases she describes in her column: unexpected collections of symptoms that she and other physicians struggle to diagnose. Dr. Sanders shows how making the right diagnosis requires expertise, painstaking procedure, and sometimes a little luck.

A fascinating account of the world’s most famous disease - polio - told as you have never heard it before. Epidemics of paralysis began to rage in the early 1900s, seemingly out of nowhere. Doctors, parents, and health officials were at a loss to explain why this formerly unheard-of disease began paralyzing so many children. Why did this disease start to become such a horrible problem during the late 1800s? Why did it affect children more often than adults? Why was it originally called teething paralysis by mothers and their doctors?

For those who could read between the lines, the censored news out of China was terrifying. But the president insisted there was nothing to worry about. Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios. Michael Lewis’ taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19.

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

Considered the definitive history of the American healthcare system, The Social Transformation of American Medicine examines how the roles of doctors, hospitals, health plans, and government programs have evolved over the last two and a half centuries. Updated with a new preface and an epilogue analyzing developments since the early 1980s, this new edition is a must-listen for anyone concerned about the future of our fraught healthcare system.

It can come in waves - like tidal waves. It changes societies. It disrupts life. It ends lives. As far back as 3000 B.C.E. (the Bronze Age), plagues have stricken mankind. COVID-19 is just the latest example, but history shows that life continues. It shows that knowledge and social cooperation can save lives. Viruses are neither alive nor dead and are the closest thing we have to zombies. Their only known function is to replicate themselves, which can have devastating consequences on their hosts.

Between Hope and Fear tells the remarkable story of vaccine-preventable infectious diseases and their social and political implications. While detailing the history of vaccine invention, Michael Kinch reveals the ominous reality that our victories against vaccine-preventable diseases are not permanent - and could easily be undone. Between Hope and Fear relates the remarkable intersection of science, technology, and disease that has helped eradicate many of the deadliest plagues known to man.

Interweaving history, original reportage, and personal narrative, Pandemic explores the origin of epidemics, drawing parallels between the story of cholera - one of history's most disruptive and deadly pathogens - and the new pathogens that stalk humankind today, from Ebola and avian influenza to drug-resistant superbugs.

The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous viruses. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile. Viruses, Plagues, and History paints a sweeping portrait of humanity's long-standing conflict with our unseen viral enemies.

In 2014, Sierra Leone, Liberia, and Guinea suffered the worst epidemic of Ebola in history. The brutal virus spread rapidly through a clinical desert, where basic health-care facilities were few and far between. Causing severe loss of life and economic disruption, the Ebola crisis was a major tragedy of modern medicine. But why did it happen, and what can we learn from it?

In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus travelled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test. As socially significant as both world wars, the Spanish flu dramatically disrupted - and often permanently altered - global politics, race relations, and family structures while spurring innovation in medicine, religion, and the arts.

Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito. Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito’s reign through human history.

It's on the television, in the papers, and in our minds. Every day we're bludgeoned by news of how bad everything is - financial collapse, unemployment, growing poverty, environmental disasters, disease, hunger, war. But the rarely acknowledged reality is that our progress over the past few decades has been unprecedented. By almost any index you care to identify, things are markedly better now than they have ever been for almost everyone alive.

Johannes Krause is the director of the Max Planck Institute for Evolutionary Anthropology and a brilliant pioneer in the field of archaeogenetics - archaeology augmented by DNA sequencing technology - which has allowed scientists to reconstruct human history reaching back hundreds of thousands of years before recorded time. In this surprising account, Krause and journalist Thomas Trappe rewrite a fascinating chapter of this history, the peopling of Europe, that takes us from the Neanderthals and Denisovans to the present.

On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?

In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.

Quarantine is our most powerful response to uncertainty: it means waiting to see if something hidden inside us will be revealed. It is also one of our most dangerous, operating through an assumption of guilt. In quarantine, we are considered infectious until proven safe. Until Proven Safe tracks the history and future of quarantine around the globe, chasing the story of emergency isolation through time and space - from the crumbling lazarettos of the Mediterranean, built to contain the Black Death, to an experimental Ebola unit in London, and from the hallways of the CDC.

Ever since the 1918 Spanish influenza pandemic, scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu to the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 "parrot fever" pandemic, through the more recent SARS, Ebola, and Zika epidemics, the last one hundred years have been marked by a succession of unanticipated pandemic alarms.

An Epidemic of Absence asks what will happen in developing countries, which, as they become more affluent, have already seen an uptick in allergic disease: Will India end up more allergic than Europe? Velasquez-Manoff also details a controversial underground movement that has coalesced around the treatment of immune-mediated disorders with parasites. Against much of his better judgment, he joins these do-it-yourselfers and reports his surprising results.

Medical doctor and national bestselling author of Make America Healthy Again Nicole Saphier reveals how politicization of the COVID-19 pandemic has baffled the public by creating distrust, fueling conspiracy theories, and making it harder for Americans to understand the necessary path forward. The pandemic has resulted in a failure of government, much of which is unavoidable in a unique disaster scenario. However, the rampant politicization of science has hopelessly muddied the water and knee-jerk anti-Trumpism made it all worse.

Filled to the brim with far-out facts, this wickedly informative narrative from the author of National Geographic's popular Gory Details blog takes us on a fascinating journey through an astonishing new reality. Blending humor and journalism in the tradition of Mary Roach, acclaimed science reporter Erika Engelhaupt investigates the gross, strange, and morbid absurdities of our bodies and our universe.

On March 11, 2011, a powerful earthquake sent a 120-foot-high tsunami smashing into the coast of northeast Japan. By the time the sea retreated, more than eighteen thousand people had been crushed, burned to death, or drowned. It was Japan’s greatest single loss of life since the atomic bombing of Nagasaki. It set off a national crisis and the meltdown of a nuclear power plant. And even after the immediate emergency had abated, the trauma of the disaster continued to express itself in bizarre and mysterious ways.

A clear-sighted revelation, a deep penetration into the world of Scientology by the Pulitzer Prize-winning author of The Looming Tower, the now-classic study of al-Qaeda’s 9/11 attack. Based on more than two hundred personal interviews with current and former Scientologists—both famous and less well known—and years of archival research, Lawrence Wright uses his extraordinary investigative ability to uncover for us the inner workings of the Church of Scientology.

As investigators brought out the bagged remains of several dozen young men from a small Chicago ranch home and paraded them in front of a crowd of TV reporters and spectators, attention quickly turned to the owner of the house. John Gacy was an upstanding citizen, active in local politics and charities, famous for his themed parties and appearances as Pogo the Clown. But in the winter of 1978-79, he became known as one of many so-called “sex murderers” who had begun gaining notoriety in the random brutality of the 1970s.

Blood carries life, yet the sight of it makes people faint. It is a waste product and a commodity pricier than oil. It can save lives and transmit deadly infections. Each one of us has roughly nine pints of it, yet many don’t even know their own blood type. And for all its ubiquitousness, the few tablespoons of blood discharged by 800 million women are still regarded as taboo: menstruation is perhaps the single most demonized biological event.

In Out Cold, science writer Phil Jaekl chronicles the underappreciated story of human innovation with cold, from Ancient Egypt, where it was used to treat skin irritations, to 18th-century London, where scientists used it in their first explorations of suspended animation. Throughout history, physicians have used cold to innovate life extension, enable distant space missions, and explore consciousness.

Barbara Butcher was early in her recovery from alcoholism when she found an unexpected lifeline: a job at the Medical Examiner’s Office in New York City. The second woman ever hired for the role of Death Investigator in Manhattan, she was the first to last more than three months. The work was gritty, demanding, morbid, and sometimes dangerous—and she loved it. In What the Dead Know, she writes with the kind of New York attitude and bravado you might expect from decades in the field, investigating more than 5,500 death scenes, 680 of which were homicides.

As a park ranger with the National Park Service's law enforcement team, Andrea Lankford led search and rescue missions in some of the most beautiful (and dangerous) landscapes across America, from Yosemite to the Grand Canyon. But though she had the support of the agency, Andrea grew frustrated with the service's bureaucratic idiosyncrasies, and left the force after twelve years. Two decades later, however, she stumbles across a mystery that pulls her right back where she left off: three young men have vanished from the Pacific Crest Trail.

The summer before his senior year in college, Greg Melville worked at the cemetery in his hometown, and thanks to hour upon hour of pushing a mower over the grassy acres, he came to realize what a rich story the place told of his town and its history. Thus was born Melville’s lifelong curiosity with how, where, and why we bury and commemorate our dead. Melville’s Over My Dead Body is a lively (pun intended) and wide-ranging history of cemeteries, places that have mirrored the passing eras in history but have also shaped it.

Most people want to avoid thinking about death, but Caitlin Doughty - a 20-something with a degree in medieval history and a flair for the macabre - took a job at a crematory, turning morbid curiosity into her life’s work. With an original voice that combines fearless curiosity and mordant wit, Caitlin tells an unusual coming-of-age story full of bizarre encounters, gallows humor, and vivid characters (both living and very dead).