In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

Perfect Mexican daughters do not go away to college. And they do not move out of their parents' house after high school graduation. Perfect Mexican daughters never abandon their family. But Julia is not your perfect Mexican daughter. That was Olga's role. Then a tragic accident on the busiest street in Chicago leaves Olga dead and Julia left behind to reassemble the shattered pieces of her family. And no one seems to acknowledge that Julia is broken, too. Instead, her mother seems to channel her grief into pointing out every possible way Julia has failed.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

After 27 years of marriage and three children, Anna Oh - wife, mother, outsider artist - has fallen in love with Viveca, the wealthy Manhattan art dealer who orchestrated her success. They plan to wed in the Oh family’s hometown of Three Rivers in Connecticut. But the wedding provokes some very mixed reactions and opens a Pandora’s Box of toxic secrets - dark and painful truths that have festered below the surface of the Ohs' lives.

Being the middle child has its ups and downs. But for Grace, an only child who was adopted at birth, discovering that she is a middle child is a different ride altogether. After putting her own baby up for adoption, she goes looking for her biological family, including: Maya, her loudmouthed younger bio sister, who has a lot to say about their newfound family ties. And Joaquin, their stoic older bio brother, who has no interest in bonding over their shared biological mother.

When Lauren and Ryan’s marriage reaches the breaking point, they come up with an unconventional plan. They decide to take a year off in the hopes of finding a way to fall in love again. One year apart, and only one rule: they cannot contact each other. Aside from that, anything goes. Lauren embarks on a journey of self-discovery, quickly finding that her friends and family have their own ideas about the meaning of marriage. These influences, as well as her own healing process and the challenges of living apart from Ryan, begin to change Lauren’s ideas about monogamy and marriage.

After grad school, Shay Dixon feels like she's had enough for awhile. Inspired by her spiritual adviser - a soul-soothing blues player named Nina Simon - Shay calls her estranged mother Nona for the first time in years, and shocks herself by asking if it would be okay to come home for a while.

Jill MacSweeny just wishes everything could go back to normal. But ever since her dad died, she's been isolating herself from her boyfriend, her best friends - everyone who wants to support her. And when her mom decides to adopt a baby, it feels like she's somehow trying to replace a lost family member with a new one.

At the age of 29, Hannah Martin still has no idea what she wants to do with her life. She has lived in six different cities and held countless meaningless jobs since graduating college. On the heels of leaving yet another city, Hannah moves back to her hometown of Los Angeles and takes up residence in her best friend Gabby’s guestroom. Shortly after getting back to town, Hannah goes out to a bar one night with Gabby and meets up with her high school boyfriend, Ethan. Just after midnight, Gabby asks Hannah if she’s ready to go. A moment later, Ethan offers to give her a ride.

Dear Anna, What I have to tell you is difficult to write, but I know it will be far more difficult for you to hear, and I'm so sorry. The unfinished letter is the only clue Tara and Emerson have to the reason behind their close friend Noelle's suicide. Everything they knew about Noelle - her calling as a midwife, her passion for causes, her love for her friends and family - described a woman who embraced life. Yet there was so much they didn't know. With the discovery of the letter and its heartbreaking secret, Noelle's friends begin to uncover the truth about this complex woman who touched each of their lives.

Newly orphaned, recently divorced, and semiadrift, Nina Popkin is on a search for her birth mother. She's spent her life looking into strangers' faces, fantasizing they're related to her, and now, at thirty-five, she's ready for answers. Meanwhile, the last thing Lindy McIntyre wants is someone like Nina bursting into her life, announcing that they're sisters and campaigning to track down their mother. She's too busy with her successful salon, three children, beautiful home, and...oh yes, some pesky little anxiety attacks.

Jonathan and Rosie have been together so long they finish each other's sentences - so when he (finally) proposes and asks her to move across the country with him, everyone is happily surprised. But when things suddenly unravel, Rosie sends Jonathan packing and moves back home with Soapie, the irascible, opinionated grandmother who raised her.

In her twenties, Emma Blair marries her high school sweetheart, Jesse. They build a life for themselves, far away from the expectations of their parents and the people of their hometown in Massachusetts. They travel the world together, living life to the fullest and seizing every opportunity for adventure. On their first wedding anniversary, Jesse is on a helicopter over the Pacific when it goes missing. Just like that, Jesse is gone forever.

Penny spends her afternoons sitting outside a sandwich shop, surrounded by ghosts. Fourteen years ago, this shop was her childhood dance studio - and she was a dancer on the rise. Now she’s a suburban housewife, dreading the moment her son departs for MIT, leaving her with an impeccably decorated McMansion and a failing marriage. She had her chance at wild, stars-in-her-eyes happiness, but that was a lifetime ago. After The Kiss. Before The Decision.