Memphis, 1939. Twelve-year-old Rill Foss and her four younger siblings live a magical life aboard their family’s Mississippi River shantyboat. But when their father must rush their mother to the hospital one stormy night, Rill is left in charge - until strangers arrive in force. Wrenched from all that is familiar and thrown into a Tennessee Children’s Home Society orphanage, the Foss children are assured that they will soon be returned to their parents - but they quickly realize the dark truth.

Early one morning in 1929, Mary Seneca Steele spontaneously packs a suitcase, gathers up her son and daughter, and drives away in her abusive and dissolute husband’s brand-new Auburn Phaeton automobile, leaving her privileged life in Charleston behind. It is the beginning of a journey of enlightenment that leads Mary “Sen” to the mountains and mysteries of Appalachia, where she will learn unexpected family secrets, create a new life for herself and her children, and finally experience love and happiness before tragedy will once again test her.

Alice Wright marries handsome American Bennett Van Cleve hoping to escape her stifling life in England. But small-town Kentucky quickly proves equally claustrophobic, especially living alongside her overbearing father-in-law. So, when a call goes out for a team of women to deliver books as part of Eleanor Roosevelt’s new traveling library, Alice signs on enthusiastically. The leader, and soon Alice's greatest ally, is Margery, a smart-talking, self-sufficient woman who's never asked a man's permission for anything.

Jillian Kane appears to have it all - a successful career, a gorgeous home, a loving husband, and two wonderful children. The reality behind closed doors is something else entirely. For nine years, she has hid the bruises and the truth of her abusive marriage in order to protect Addie and Drew, knowing that if she left, Gordon would destroy her and destroy them. When she flees in an act of desperation, her worst nightmare is realized and she finds herself on the run with her two young children, no money, and no plan.

For years, rumors of the "Marsh Girl" have haunted Barkley Cove, a quiet town on the North Carolina coast. So in late 1969, when handsome Chase Andrews is found dead, the locals immediately suspect Kya Clark, the so-called Marsh Girl. But Kya is not what they say. Sensitive and intelligent, she has survived for years alone in the marsh that she calls home, finding friends in the gulls and lessons in the sand.

Texas, 1921. A time of abundance. The Great War is over, the bounty of the land is plentiful, and America is on the brink of a new and optimistic era. But for Elsa Wolcott, deemed too old to marry in a time when marriage is a woman’s only option, the future seems bleak. Until the night she meets Rafe Martinelli. By 1934, the world has changed; millions are out of work and drought has devastated the Great Plains. Elsa must make an agonizing choice: fight for the land she loves or leave it behind and go west, to California, in search of a better life for her family.

Ernt Allbright, a former POW, comes home from the Vietnam war a changed and volatile man. When he loses yet another job, he makes an impulsive decision: He will move his family north, to Alaska, where they will live off the grid in America’s last true frontier.

At the end of the Second World War, Cyril Conroy combines luck and a single canny investment to begin an enormous real estate empire, propelling his family from poverty to enormous wealth. His first order of business is to buy the Dutch House, a lavish estate in the suburbs outside of Philadelphia. Meant as a surprise for his wife, the house sets in motion the undoing of everyone he loves. The story is told by Cyril’s son Danny, as he and his older sister, the brilliantly acerbic and self-assured Maeve, are exiled from the house where they grew up by their stepmother.

In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

Jeannette Walls grew up with parents whose ideals and stubborn nonconformity were both their curse and their salvation. Rex and Rose Mary Walls had four children. In the beginning, they lived like nomads, moving among Southwest desert towns, camping in the mountains. Rex was a charismatic, brilliant man who, when sober, captured his children's imagination. Rose Mary painted and wrote and couldn't stand the responsibility of providing for her family; she called herself an "excitement addict."

Meredith and Nina Whitson are as different as sisters can be. One stayed at home to raise her children and manage the family apple orchard; the other followed a dream and traveled the world to become a famous photojournalist. But when their beloved father falls ill, Meredith and Nina find themselves together again, standing alongside their cold, disapproving mother, Anya, who even now, offers no comfort to her daughters.

Sam Hill always saw the world through different eyes. Born with red pupils, he was called “Devil Boy” or Sam “Hell” by his classmates; “God’s will” is what his mother called his ocular albinism. Her words were of little comfort, but Sam persevered. Sam believed it was God who sent Ernie Cantwell, the only African American kid in his class, to be the friend he so desperately needed. And that it was God’s idea for Mickie Kennedy to storm into Our Lady of Mercy like a tornado, uprooting every rule Sam had been taught about boys and girls. Forty years later, Sam, a small-town eye doctor, is no longer certain anything was by design.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

In 1958 Georgia, the shade of a 13-year-old black girl's skin can make the difference in her fate. Tangy Mae is the smartest of her mother's 10 children, but she is also the darkest complected. The Quinns - all different skin shades, all with unknown fathers - live with their charismatic, beautiful, and tyrannical mother, Rozelle, in poverty on the fringes of a Georgia town where Jim Crow rules. Rozelle's children live in fear of her mood swings and her violence, but they are devoted to her. Rozelle pulls her children out of school when they are 12 years old so that they can help support her by going to work.

Rita and Rosie Stevens are only nine and five years old when their widowed mother marries a violent bully called Jimmy Randall and has a baby boy by him. Under pressure from her new husband, she is persuaded to send the girls to an orphanage, not knowing that the papers she has signed will entitle them to do what they like with the children. And it is not long before the powers that be decide to send a consignment of orphans to their sister institution in Australia. Among them - without their family's consent or knowledge - are Rita and Rosie.