
Valley of Forgetting
Alzheimer's Families and the Search for a Cure
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Narrated by:
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Carolina Hoyos
About this listen
The riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer’s disease
“Powerful. . . . a poignant depiction of a community in crisis.”—Publishers Weekly
In the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer’s disease. Over the next forty years of working with the “paisa mutation” kindred, he went on to build a world-class research program in a region beset by violence and poverty.
In Valley of Forgetting, Jennie Erin Smith brings listeners into the clinic, the laboratories, and the Medellín trial center where Lopera’s patients receive an experimental drug to see if Alzheimer’s can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones’ brains to science and subjected themselves to invasive testing to help uncover how Alzheimer’s develops and whether it can be stopped. Findings from this unprecedented effort could hold the key to understanding and treating the disease, though it is unclear what, if anything, the families will receive in return.
Smith’s immersive storytelling brings this complex drama to life, inviting listeners on a scientific journey that is as deeply moving as it is engrossing.
©2025 Jennie Erin Smith (P)2025 Penguin AudioCritic reviews
“A multigenerational saga that is a compelling story in itself. . . . [Smith] has spent years inside the homes of both the patients and the researchers, and in exam rooms and other intimate spaces that give the author a stunning level of vivid firsthand detail.”—BookPage (starred review)
“Jennie Erin Smith writes with such narrative skill, such empathy and curiosity, such a strong sense of the place where science and people meet, that you come out with the feeling of having witnessed an extraordinary investigation into the mysteries of what makes us human.”—Juan Gabriel Vásquez, author of The Sound of Things Falling
“Valley of Forgetting is the masterfully told story of how, over the past four decades, a human drama of extraordinary significance has quietly unfolded in a rural province of Colombia. Jennie Erin Smith deserves a wide readership for this book that is at once revealing, unsettling, timely, and ultimately, deeply moving.”—Jon Lee Anderson, author of Che Guevara: A Revolutionary Life and To Lose a War
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Story
From That Small Island: The Story of the Irish is a global and ambitious retelling of Irish history that explores these questions to ask how Ireland has been shaped by the world and the world has been shaped by the Irish. From the island's earliest settlers more than 12,000 years ago to today and from Europe and North America to Asia, Africa, and South America, Bríona Nic Dhiarmada and Jane Ohlmeyer offer a new narrative of Irish history: open and integrated, situated within its broader global and environmental contexts, and peopled by the voices of those who have often been excluded from it.
By: Jane Ohlmeyer, and others
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Miracles and Wonder
- The Historical Mystery of Jesus
- By: Elaine Pagels
- Narrated by: Eunice Wong
- Length: 8 hrs and 54 mins
- Unabridged
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Overall
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Performance
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Story
Early in her career, Elaine Pagels changed our understanding of the origins of Christianity with her work in The Gnostic Gospels. Now, in the culmination of a decades-long career, she explores the biggest subject of all, Jesus. In Miracles and Wonder she sets out to discover how a poor young Jewish man inspired a religion that shaped the world.
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I had high hopes for this title
- By Christine on 04-02-25
By: Elaine Pagels
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To Lose a War
- The Fall and Rise of the Taliban
- By: Jon Lee Anderson
- Length: 12 hrs
- Unabridged
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Overall
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Performance
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Story
From one of the greatest foreign correspondents of our time, whose essential and profound on the ground reporting from Afghanistan for The New Yorker from before 9/11 to the return of the Taliban to power in 2021 has definitively shaped our understanding of the country and its fate, comes the complete accounting of that era, combining previously published dispatches and new reporting into a narrative of great impact and lasting value.
By: Jon Lee Anderson