Joan Goodwin has been obsessed with the stars for as long as she can remember. Thoughtful and reserved, Joan is content with her life as a professor of physics and astronomy at Rice University and as aunt to her precocious niece, Frances. That is, until she comes across an advertisement seeking the first women scientists to join NASA’s space shuttle program. Suddenly, Joan burns to be one of the few people to go to space.

Sara has just landed at LAX, returning home from a conference abroad, when agents from the Risk Assessment Administration pull her aside and inform her that she will soon commit a crime. Using data from her dreams, the RAA’s algorithm has determined that she is at imminent risk of harming the person she loves most: her husband. For his safety, she must be kept under observation for twenty-one days. The agents transfer Sara to a retention center, where she is held with other dreamers, all of them women trying to prove their innocence from different crimes.

Doctor Jack Troy was born and raised in Faha, but his responsibilities for the sick and his care for the dying mean he has always been set apart from the town. His eldest daughter, Ronnie, has grown up in her father’s shadow, and remains there, having missed one chance at love – and passed up another offer of marriage from an unsuitable man. But in the Advent season of 1962, as the town readies itself for Christmas, Ronnie and Doctor Troy’s lives are turned upside down when a baby is left in their care.

At forty, Peter, an asylum lawyer in New York City, is overworked and isolated. He spends his days immersed in the struggles of immigrants only to return to an empty apartment and occasional hook-ups with a man who wants more than Peter can give. But when the asylum case of a young gay man pierces Peter's numbness, the event that he has avoided for twenty years returns to haunt him. Ann, his mother, who runs a women's retreat center she founded after leaving his father, is wounded by the estrangement from Peter but cherishes the world she has built.

The four Endicott siblings—Gemma, Connor, Roddy, and Jude—were once inseparable, a bond created by the absence of their dazzling, mercurial mother, who would return for a few weeks each summer to whisk them off on sprawling road trips around the country. Decades later, the unthinkable has happened: the Endicotts haven’t spoken in years . . . until an out-of-the-blue text arrives from Jude, now a famous actress, summoning them to a small town in North Dakota.

His family farm and the surrounding community now emptied by war, young Hani embarks on an epic quest–assisted by a brooding yet brilliant donkey–to find his lost sister in the ruins of Troy. Some war stories transcend time and circumstance, and so it is with the resourceful and heartbroken Hani, who must employ every bit of intelligence, every scrap of ingenuity, and ultimately every ounce of his spirit and humor to withstand the forces of civilization’s collapse.

The third of four children born to a middle-class Calcutta family, quiet Durga is surprisingly the first to leave the nest of her loving, overbearing family. She is not as charming as her older sister, Tia, as lighthearted as her brother, Arjun, or as clever as her younger sister, Parul. But when she arrives in Ireland to work at a tech company, she finds that for the first time ever she is free—to have fun, to stay out, to sample everything that life has to offer. Suddenly, Durga can be whoever she wants to be. And she wants it all. But freedom comes at a price.

Lily—a bored, beautiful twenty-something—wakes up on a remote desert compound, alongside nineteen other contestants competing on a massively popular reality show. To win, she must outlast her housemates to stay in the Compound the longest, while competing in challenges for luxury rewards like champagne and lipstick, plus communal necessities to outfit their new home, like food, appliances, and a front door. Cameras are catching all her angles, good and bad, but Lily has no desire to leave: why would she, when the world outside is falling apart?

The venerated Reverend Doctor John Freeman did not raise his son, Davis, to be touched by any man, let alone a white man. He did not raise his son to whisper that man’s name with tenderness. But on the eve of his wedding, all Davis can think about is how beautiful he wants to look when he meets his beloved Everett at the altar. Never mind that his mother, who died decades before, and his father, whose anger drove Davis to flee their home in Chagrin Falls, Ohio, for a freer life in New York City, won’t be there to walk him down the aisle.

Pauline, a young chambermaid who works at the legendary Mapes Hotel in Reno, Nevada, is asked to step in for a colleague and clean Suite 614. Although she was told the rooms were empty, a dazed, sleepy woman appears before her. This is Mrs. Miller, aka Marilyn Monroe, whose stay in Reno coincides with the breakdown of her marriage to Arthur Miller and the filming of what was to be her last film, The Misfits.

Sybil Van Antwerp has throughout her life used letters to make sense of the world and her place in it. Most mornings, around half past ten, Sybil sits down to write letters—to her brother, to her best friend, to the president of the university who will not allow her to audit a class she desperately wants to take, to Joan Didion and Larry McMurtry to tell them what she thinks of their latest books, and to one person to whom she writes often yet never sends the letter.

The Kenner siblings are at odds. Jenn is a harried mom struggling under the weight of family obligations. Fred is a novelist who can’t write, maybe because she’s lost faith in storytelling itself. Jude is a recovering corporate lawyer with her own story to tell, and a grudge against her former favorite sister, Fred. George, the baby, is estranged from his wife and harboring both a secret about his former employer and an ill-advised crush on one of his sisters’ friends. Gathered after a major loss, each sibling needs the others more than ever—if only they could trust each other.

When Diane Schwebe, the director of a major New York museum, is awakened in the early morning by a text message from the museum’s lawyer, it is the start of a twenty-four hour roller-coaster ride. Diane has sacrificed many things in her life to help the fading institution stave off irrelevance and financial ruin. In this battle, she’s surrounded by her stalwart supporters and a motley assortment of museum employees, each on the precipice of collapse or revelation.

After suffering her first big heartbreak two years earlier, Penelope Lin has built a quiet life with no romantic entanglements. She spends her days cataloging a museum's vast collection of Qing Dynasty bound-foot shoes and in the comfortable company of close friends. One day, she happens to meet Hoang, who confesses to releasing mice from the cancer research lab where he works. Hoang's openness catches Penelope off guard; from then on, she finds her carefully constructed life slowly start to unravel.

Yetunde awakens aboard a slave ship en route to the United States with the spirit of her dead sister as her only companion. Desperate to survive the hell that awaits her at their destination, Yetunde finds help in an unexpected form—the Devil himself. The Devil, seeking a way to reenter the pearly gates of heaven, decides to prove himself to an indifferent God by protecting Yetunde and granting her a piece of his supernatural power. In return, Yetunde makes an incredible sacrifice.

When Hester is diagnosed with terminal cancer on her fortieth birthday, she knows immediately what she must do: abandon her possessions and drive to California to kill her estranged father. With no friends or family tying her to the life she’s built in New York City, she quits her wildly lucrative job in corporate law and starts driving west. She hasn’t made it far when she runs into John, an environmental activist in need of a ride to different superfund sites across the United States.

Sylvie is happy only when she’s in therapy. This is because Sylvie is in love with her therapist; she thinks about her every second they’re not together (roughly 167 hours and 10 minutes per week). In that room, Sylvie is able to talk about everything: the false hope promised by eighties music; what a dog’s inner life is really like and how sad, she, Sylvie is, outside that room. She’s aware she has an obsession, but whether it’s some flavor of erotic transference or a lost person’s need to connect, Sylvie isn’t sure.

In the wake of a catastrophic storm, Cora sets off with her nine-year-old daughter, Maia, to register her son's birth. Her husband, Gordon, a local doctor, respected in the community but a terrifying and controlling presence at home, intends for her to name the infant after him. But when the registrar asks what she'd like to call the child, Cora hesitates...

Abe Jacobs is Kanien’kehá:ka from Ahkwesáhsne—or, as white people say, a Mohawk Indian from the Saint Regis Tribe. At eighteen, Abe left the reservation where he was raised and never looked back. Now forty-three, Abe is suffering from a rare disease—one his doctors in Miami believe will kill him.

Duc Tran, the eccentric founder of the Vietnamese sandwich chain Duc’s Sandwiches, has decided to retire. No one has heard from his wife, Evelyn, in two decades. She abandoned the family without a trace, and clearly doesn’t want anything to do with Duc, the business, or their kids. But the money has to go to someone. With the help of the shady family lawyer, Duc informs his five estranged adult children that to receive their inheritance, his four daughters must revitalize run-down shops in old-school Little Saigon locations across America: Houston, San Jose, New Orleans, and Philadelphia.