A silent epidemic of chronic illnesses afflicts tens of millions of Americans: These are diseases that are poorly understood, frequently marginalized, and can go undiagnosed and unrecognized altogether. Renowned writer Meghan O’Rourke delivers a revelatory investigation into this elusive category of “invisible” illness that encompasses autoimmune diseases, post-treatment Lyme disease syndrome, and now long COVID, synthesizing the personal and the universal to help all of us through this new frontier.

From a darkened world, bound by four walls, a young woman called Jessica tells the tale of her battle against the M. E. Monster. The severest form of a neuroimmune disease called Myalgic Encephalomyelitis went to war with her at just 15 years old. From beneath her dark glasses, Jessica glimpses a world far different from the one she remembers as a teenage schoolgirl. This true story follows her path as she ends up living in a hospital for years with tubes keeping her alive.

In the summer of 2015, Ross Douthat was moving his family, with two young daughters and a pregnant wife, from Washington, DC, to a sprawling farmhouse in a picturesque Connecticut town when he acquired a mysterious and devastating sickness. It left him sleepless, crippled, wracked with pain - a shell of himself. After months of seeing doctors and descending deeper into a physical inferno, he discovered that he had a disease which, according to CDC definitions, does not actually exist.

As Melissa Bond raises her infant daughter and a special-needs one-year-old son, she suffers from unbearable insomnia, sleeping an hour or less each night. She loses her job as a journalist (a casualty of the 2008 recession), and her relationship with her husband grows distant. Her doctor casually prescribes benzodiazepines—a family of drugs that includes Xanax, Valium, Klonopin, Ativan—and increases her dosage regularly.

Talking about death and dying is considered taboo in polite company, and even in the medical field. Our ideas about dying are confusing at best: Will our memories flash before our eyes? Regrets consume our thoughts? Does a bright light appear at the end of a tunnel? For most people, it will be a slower process, one eased with preparedness, good humor, and a bit of faith. At the forefront of changing attitudes around palliative care is hospice nurse Hadley Vlahos, who shows that end-of-life care can teach us just as much about how to live as it does about how we die.

From New York Times best-selling author and blogger Heather B. Armstrong comes an honest and irreverent memoir - reminiscent of the New York Times best-seller Brain on Fire - about her experience as one of only a few people to participate in an experimental treatment for depression involving 10 rounds of a chemically induced coma approximating brain death.

In the summer after graduating from college, Suleika Jaouad was preparing, as they say in commencement speeches, to enter “the real world”. She had fallen in love and moved to Paris to pursue her dream of becoming a war correspondent. The real world she found, however, would take her into a very different kind of conflict zone. It started with an itch - first on her feet, then up her legs, like a thousand invisible mosquito bites. Then a trip to the doctor and, a few weeks shy of her 23rd birthday, a diagnosis: leukemia, with a 35 percent chance of survival.

Meant to be a last-minute anniversary gift for her then boyfriend (and now husband), the highly energetic and loud-mouthed Vizla puppy named Harlow turns out to be the best snap decision twenty-year-old Taylor ever makes—and the beginning of the most epic friendship she ever has. As Wolfe’s resistance to 9-5’s and traditional adulthood grows, Harlow becomes the perfect companion for her eccentricities in a world that thrives on conformity.

Margaret Jacobsen is just about to step into the bright future she’s worked for so hard and so long: a new dream job, a fiancé she adores, and the promise of a picture-perfect life just around the corner. Then, suddenly, on what should have been one of the happiest days of her life, everything she worked for is taken away in a brief, tumultuous moment. In the hospital and forced to face the possibility that nothing will ever be the same again, Maggie must confront the unthinkable.

After 30 years of a healthy, rewarding, and exciting life, I wake up in a hospital bed unable to move. The neurosurgeon leans down and breaks the news: You won't regain any function in your body and you will never walk again. My medical insurance sends me home, discontinues my care, and tells me to "adapt to my new life". Little Big Steps is the story of the pivotal moments, interactions, and breakthroughs following the injury that turned my life upside down.

On the way home from swim practice, 18-year-old athlete Brian Boyle’s future changed in an instant when a dump truck plowed into his Camaro. He was airlifted to a shock-trauma hospital. He had lost sixty percent of his blood, his heart had moved across his chest, and his organs and pelvis were pulverized. He was placed in a medically-induced coma.

Best friends Lindsey, Kendra, and Dani endure every parent’s nightmare when a tragic accident befalls their teenage boys, leaving one dead, another in a coma, and a third too traumatized to speak. Reeling from the worst night of their lives, the three mothers plunge into a desperate investigation of the bizarre incident. How could something so horrible happen in their wealthy Southern California suburb? They soon discover that the accident was just the beginning, and troubling discoveries lead to chilling questions: Do they really know their children? Do they even know each other?

Oksana Masters was born in Ukraine—in the shadow of Chernobyl—seemingly with the odds stacked against her. She came into the world with one kidney, a partial stomach, six toes on each foot, webbed fingers, no right bicep, and no thumbs. Her left leg was six inches shorter than her right, and she was missing both tibias.

Two years and 6,000 miles away from the explosion that took his leg, Josh Carpenter struggles to reclaim his former life as a college student. Mary Fischer, a civilian for the first time in years, strikes out on her own to create a new, independent life away from the army and her controlling mother. The last time Josh saw Mary, his National Guard unit was leaving Kuwait, headed north to the war. The last time Mary saw Josh, she watched as his unconscious body was rolled onto a plane bound for a hospital in Germany.

After being diagnosed in her early forties with metastatic melanoma - a "rapidly fatal" form of cancer - journalist and mother of two Mary Elizabeth Williams finds herself in a race against the clock. She takes a once-in-a-lifetime chance and joins a clinical trial for immunotherapy, a revolutionary drug regimen that trains the body to vanquish malignant cells. Astonishingly, her cancer disappears entirely in just a few weeks. But at the same time, her best friend embarks on a cancer journey of her own - with very different results.