Listen in as Drs Michael Wechsler and Geoffrey Chupp discuss real-world examples of how they use precision medicine in their own clinics to treat moderate to severe asthma.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969685). The topics and discussions are planned, produced, and reviewed independently of the advertiser. This podcast is intended only for US healthcare professionals.

Resources

Theophylline (Rx) https://reference.medscape.com/drug/theo-24-theochron-theophylline-343447

Merged Affinity Network Association Clustering: Joint Multi-Omic/Clinical Clustering to Identify Disease Endotypes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195153/

How Is the Type 2 (T2 High) Subtype of Asthma? https://www.medscape.com/answers/137501-198413/how-is-the-type-2-t2-high-subtype-of-asthma

Targeting Interleukins to Treat Severe Asthma https://www.medscape.com/viewarticle/771133_4

Asthma Workup https://emedicine.medscape.com/article/296301-workup

ImmunoCAP for IgE-Mediated Hyperreactivity Analysis https://www.bioagilytix.com/immunocap-platform-for-immunogenicity-testing/

Bronchiectasis https://emedicine.medscape.com/article/296961-overview

T-Helper Type 2–Driven Inflammation Defines Major Subphenotypes of Asthma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742757/

Efficacy and Safety of Tralokinumab in Patients With Severe Uncontrolled Asthma: A Randomised, Double-blind, Placebo-Controlled, Phase 2b Trial https://linkinghub.elsevier.com/retrieve/pii/S2213-2600(15)00197-6

Mepolizumab for Prednisone-Dependent Asthma With Sputum Eosinophilia https://www.nejm.org/doi/full/10.1056/nejmoa0805435

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma https://www.nejm.org/doi/full/10.1056/nejmoa0808991

Effect of Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma (AMAZES): A Randomised, Double-blind, Placebo-Controlled Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31281-3/fulltext

A Randomized, Open-Label, Pragmatic Study to Assess Reliever-Triggered Inhaled Corticosteroid in African American/Black and Hispanic/Latinx Adults With Asthma: Design and Methods of the PREPARE Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130188/

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study https://clinicaltrials.gov/ct2/show/NCT04129931

Drs Michael Wechsler and Mario Castro discuss precision medicine for moderate to severe asthma and the past, present, and future of clinical trials.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969686). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE) Network https://preciseasthma.org/preciseweb/

Asthma https://emedicine.medscape.com/article/296301-overview

The Many 'Buckets' of Severe Asthma: Moving Toward Personalized Managements https://www.jaci-inpractice.org/article/S2213-2198(17)30379-3/pdf

What is Fractional Exhaled Nitric Oxide (FeNO) in Pulmonary Function Testing?https://www.medscape.com/answers/303239-77907/what-is-fractional-exhaled-nitric-oxide-feno-in-pulmonary-function-testing

Periostin is a Systemic Biomarker of Eosinophilic Airway Inflammation in Asthmatic Patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626285/

Asthma Workup Approach Considerations https://emedicine.medscape.com/article/296301-workup

PrecISE: Precision Medicine in Severe Asthma: An Adaptive Platform Trial With Biomarker Ascertainment https://www.jacionline.org/article/S0091-6749(21)00352-3/fulltext

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma https://www.nejm.org/doi/full/10.1056/NEJMoa1613125

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study https://clinicaltrials.gov/ct2/show/NCT04129931

Designing Clinical Trials to Address the Needs Of Childhood And Adult Asthma: The National Heart, Lung, and Blood Institute's AsthmaNet https://www.jacionline.org/article/S0091-6749(13)01638-2/pdf

Severe Asthma Research Program http://www.severeasthma.org/

Airways Clinical Research Centers https://www.lung.org/research/airways-clinical-research-centers

Lung Health Cohort Study: Making History https://www.lung.org/research/lung-health-cohort-study

Drs Wechsler and Akuthota discuss novel therapies in severe asthma treatment, including precision medicine, biomarkers, and new biologic agents.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969688). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Omalizumab https://reference.medscape.com/drug/xolair-omalizumab-343444

Mepolizumab https://reference.medscape.com/drug/nucala-mepolizumab-1000034

Bronchial Thermoplasty https://emedicine.medscape.com/article/2094272-overview

Eosinophilic Asthma and Sputum Eosinophilia https://www.webmd.com/asthma/eosinophilic-asthma-defined

Role of T2 Inflammation Biomarkers in Severe Asthma https://reference.medscape.com/medline/abstract/26574724

Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry https://linkinghub.elsevier.com/retrieve/pii/S2213-2198(21)00311-1

Dupilumab Prescribing Information https://www.regeneron.com/downloads/dupixent_fpi.pdf

FDA Approves Cinqair to Treat Severe Asthma https://www.fda.gov/news-events/press-announcements/fda-approves-cinqair-treat-severe-asthma

Benralizumab https://reference.medscape.com/drug/fasenra-benralizumab-1000213

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) https://emedicine.medscape.com/article/333492-overview

Hypereosinophilic Syndrome https://emedicine.medscape.com/article/202030-overview

Anti-IL-5 Therapy in Patients With Severe Eosinophilic Asthma – Clinical Efficacy and Possible Criteria for Treatment Response https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-018-0689-2

Mepolizumab for Severe Eosinophilic Asthma (DREAM): A Multicentre, Double-blind, Placebo-Controlled Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60988-X/fulltext

Allergic and Environmental Asthma https://emedicine.medscape.com/article/137501-overview

FDA Approves Maintenance Treatment for Severe Asthma https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-maintenance-treatment-severe-asthma

Tezepelumab in Adults and Adolescents With Severe, Uncontrolled Asthma https://www.nejm.org/doi/full/10.1056/NEJMoa2034975

Efficacy and Safety of Itepekimab in Patients With Moderate-to-Severe Asthma https://www.nejm.org/doi/10.1056/NEJMoa2024257

The Targeted Eosinophil-Lowering Effects of Dexpramipexole in Clinical Studies https://www.sciencedirect.com/science/article/abs/pii/S107997961630328X

CRTH2 Antagonists in Asthma: Current Perspectives https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733922

Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE) https://preciseasthma.org/preciseweb/

A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype https://clinicaltrials.gov/ct2/show/NCT04718389

Drs Wechsler and Jackson discuss their partnerships with nurses, asthma educators, psychologists, speech therapists, and other specialists when diagnosing and treating patients with severe asthma.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969689). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Asthma https://emedicine.medscape.com/article/296301-overview

Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma https://jamanetwork.com/journals/jama/fullarticle/2598265

Churg-Strauss Disease https://emedicine.medscape.com/article/1178795-overview

Aspergillosis https://emedicine.medscape.com/article/296052-overview

Chronic Obstructive Pulmonary Disease (COPD) https://emedicine.medscape.com/article/297664-overview

Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview#a9

Esophageal Manometry https://emedicine.medscape.com/article/1891791-overview

Obstructive Sleep Apnea (OSA) https://emedicine.medscape.com/article/295807-overview

Granulomatosis With Polyangiitis (GPA, formerly Wegener Granulomatosis) https://emedicine.medscape.com/article/332622-overview

Anti-IL–5 Therapy in Patients With Severe Eosinophilic Asthma https://www.medscape.com/viewarticle/900560

Strongyloidiasis Infection FAQs https://www.cdc.gov/parasites/strongyloides/gen_info/faqs.html

What are the social and environmental determinants of asthma? Drs Wechsler, Cardet, and Kraft have a wide-ranging discussion about the science, publications, and their experience as clinicians.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969690). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Asthma https://emedicine.medscape.com/article/296301-overview

The School Inner-City Asthma Intervention Study: Design, Rationale, Methods, and Lessons Learned https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557648/

2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://www.jacionline.org/article/S0091-6749(20)31404-4/fulltext

Allergic and Environmental Asthma https://emedicine.medscape.com/article/137501-overview

Comparing Asthma Treatments: A Study Focusing on African-American, Hispanic, and Latino Adults -- The PREPARE Study for PeRson EmPowered Asthma Relief https://www.pcori.org/research-results/2016/comparing-asthma-treatments-study-focusing-african-american-hispanic-and-latino-adults-prepare-study-person-empowered-asthma-relief

Percentage of People With Asthma Who Smoke https://www.cdc.gov/asthma/asthma_stats/people_who_smoke.htm

Associations Between Historical Residential Redlining and Current Age-Adjusted Rates of Emergency Department Visits Due to Asthma Across Eight Cities in California: An Ecological Study https://linkinghub.elsevier.com/retrieve/pii/S2542-5196(19)30241-4

Socioeconomic Status and Asthma Control in African American Youth in SAGE II https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257058/

Combatting the Health Consequences of Poverty and Stress https://www.hsph.harvard.edu/news/magazine/fall09wrights/

Designing Clinical Trials to Address the Needs of Childhood and Adult Asthma: The National Heart, Lung, and Blood Institute's AsthmaNet https://www.jacionline.org/article/S0091-6749(13)01638-2/fulltext

AsthmaNet Best African American Response to Asthma Drugs (BARD) https://biolincc.nhlbi.nih.gov/studies/asthmanet_bard/

Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899291/

Primary Adherence to Controller Medications for Asthma Is Poor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342835/

Asthma and African Americans https://minorityhealth.hhs.gov/omh/browse.aspx?lvl=4&lvlid

Drs Wechsler, Bacharier, and Phipatanakul discuss moderate to severe childhood asthma.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969691). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources:

Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network https://preciseasthma.org/preciseweb/

Inhaled Corticosteroid Therapy in Children: An Assessment of the Potential for Side Effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC475319/pdf/thorax00304-0005.pdf

Inhaled Corticosteroids in Children: Effects on Bone Mineral Density and Growth https://linkinghub.elsevier.com/retrieve/pii/S2213-2600(14)70024-4

Aerochamber https://aerochamber.com/

Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview

Using Impulse Oscillometry in Clinical Practice https://www.medscape.com/viewarticle/862265

Global Initiative for Asthma Guidelines https://ginasthma.org/

National Asthma Education Prevention Program Guidelines https://www.nhlbi.nih.gov/health-topics/asthma-management-guidelines-2020-updates

Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf

Mepolizumab Prescribing Information https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Nucala/pdf/NUCALA-PI-PIL-IFU-COMBINED.PDF

Benralizumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/3647bed4-ce91-4fe7-9bc5-32dbee73f80a/3647bed4-ce91-4fe7-9bc5-32dbee73f80a_viewable_rendition__v.pdf

Dupilumab in Children With Uncontrolled Moderate-to-Severe Asthma https://www.nejm.org/doi/10.1056/NEJMoa2106567

Dupilumab Prescribing Information https://www.regeneron.com/downloads/dupixent_fpi.pdf

Tezepelumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/e306dc06-d580-4457-b15f-9f28545ad63a/e306dc06-d580-4457-b15f-9f28545ad63a_viewable_rendition__v.pdf

Preventing Asthma in High Risk Kids (PARK) With Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887056/

Join Drs Mike Wechsler and Josh Kosowsky as they work through the management of a patient presenting with moderate to severe asthma in the ER.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987112). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Asthma https://emedicine.medscape.com/article/296301-overview

National Center for Health Statistics - Asthma https://www.cdc.gov/nchs/fastats/asthma.htm

Beta2-Agonists https://www.ncbi.nlm.nih.gov/books/NBK542249/

Noninvasive Ventilation Procedures https://emedicine.medscape.com/article/1417959-overview

The Use of Heliox in Critical Care https://pubmed.ncbi.nlm.nih.gov/25024941/

High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients With Severe Bronchial Asthma Complicated With Respiratory Failure https://pubmed.ncbi.nlm.nih.gov/32211084/

Anti-IL-5 Therapies for Asthma https://pubmed.ncbi.nlm.nih.gov/35838542/

Recent Advances in the Inhibition of the IL-4 Cytokine Pathway for the Treatment of Allergen-Induced Asthma https://pubmed.ncbi.nlm.nih.gov/34948449/

Targeting TSLP in Asthma https://pubmed.ncbi.nlm.nih.gov/35685846/

National Hospital Ambulatory Medical Care Survey: 2020 Emergency Department Summary Tables https://www.cdc.gov/nchs/data/nhamcs/web_tables/2020-nhamcs-ed-web-tables-508.pdf

FDA Approves Drug Combination Treatment for Adults With Asthma https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-combination-treatment-adults-asthma

Join Drs Mike Wechsler and Mario Castro as they discuss the diagnosis and treatment of allergic asthma in the clinic.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987113). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Asthma: A Syndrome Composed of Heterogeneous Diseases https://pubmed.ncbi.nlm.nih.gov/18681077/

Allergic Endotypes and Phenotypes of Asthma https://pubmed.ncbi.nlm.nih.gov/32037107/

Comorbidities and the Impact of Atopic Dermatitis https://pubmed.ncbi.nlm.nih.gov/31034875/

Biomarkers for Diagnosis and Prediction of Therapy Responses in Allergic Diseases and Asthma https://pubmed.ncbi.nlm.nih.gov/32893900/

2023 GINA Report for Asthma https://pubmed.ncbi.nlm.nih.gov/37302397/

Pulmonary Function Testing in the Diagnosis of Asthma: A Population Study https://pubmed.ncbi.nlm.nih.gov/22030804/

Using Fractional Exhaled Nitric Oxide Measurement in Clinical Asthma Management https://pubmed.ncbi.nlm.nih.gov/34673021/

2020 NAEPP Guidelines Update and GINA 2021-Asthma Care Differences, Overlap, and Challenges https://pubmed.ncbi.nlm.nih.gov/34718214/

Understanding the Key Issues in the Treatment of Uncontrolled Persistent Asthma With Type 2 Inflammation https://pubmed.ncbi.nlm.nih.gov/33542055/

2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://pubmed.ncbi.nlm.nih.gov/33280709/

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial https://pubmed.ncbi.nlm.nih.gov/21536936/

Dupilumab Efficacy in Patients With Uncontrolled, Moderate-to-Severe Allergic Asthma https://pubmed.ncbi.nlm.nih.gov/31521831/

Efficacy of Tezepelumab in Patients With Evidence of Severe Allergic Asthma: Results From the Phase 3 NAVIGATOR Study https://pubmed.ncbi.nlm.nih.gov/36507576/

The Evolving Landscape of Immunotherapy for the Treatment of Allergic Conditions https://pubmed.ncbi.nlm.nih.gov/37170653/

Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf