"The dead can't hurt you. Only the living can." Effie Jones, a former slave who escaped to the Union side as a child, knows the truth of her words. Taken in by an army surgeon and his wife during the War, she learned to read and write, to tolerate the sight of blood and broken bodies - and to forget what is too painful to bear. Now a young freedwoman, she has returned south to New Orleans and earns her living as an embalmer, her steady hand and skillful incisions compensating for her white employer's shortcomings.

Once a trailblazer in the field of medicine, Dr. Tucia Hatherley hasn't touched a scalpel or stethoscope since she made a fatal mistake in the operating theater. Instead, she works in a corset factory, striving to earn enough to support her disabled son. When even that livelihood is threatened, Tucia is left with one option-to join a wily, charismatic showman named Huey and become part of his traveling medicine show.

In the slums of 1880s New York, Una Kelly has grown up to be a rough-and-tumble grifter, able to filch a pocketbook in five seconds flat. But when another con-woman pins her for a murder she didn't commit, Una is forced to flee. Running from the police, Una lies her way into an unlikely refuge: the nursing school at Bellevue Hospital.

Eleven-year-old Grace Carter has a talent for hiding things. She's had plenty of practice, burying thoughts and feelings that might anger her strict evangelical pastor father. The Knowing, as Grace calls it, offers glimpses of people's pasts and futures. It enables her to see into the depth of her mother's sadness, and even allows Grace to talk to Isaac, her twin brother who died at birth. To her wise, loving Aunt Pearl, the Knowing is a family gift; to her daddy, it's close to witchcraft.

Los Angeles, 1920s: Socialite Mirielle West's days are crowded with shopping, luncheons, and prepping for the myriad glittering parties she attends with her actor husband, Charlie. She's been too busy to even notice the small patch of pale skin on the back of her hand. Other than an occasional overindulgence in gin and champagne, which helps to numb the pain of recent tragedy, Mirielle is the picture of health. But her doctor insists on more tests, and Mirielle reluctantly agrees. The diagnosis - leprosy - is devastating and unthinkable.

On a summer evening in 1931, Lilly Blackwood glimpses circus lights from the grimy window of her attic bedroom. Lilly isn't allowed to explore the meadows around Blackwood Manor. She's never even ventured beyond her narrow room. Momma insists it's for Lilly's own protection, that people would be afraid if they saw her. But on this unforgettable night, Lilly is taken outside for the first time - and sold to the circus sideshow.

In early 1943, Magda Ritter's parents send her to relatives in Bavaria, hoping to keep her safe from the Allied bombs strafing Berlin. Young German women are expected to do their duty - working for the Reich or marrying to produce strong, healthy children. After an interview with the civil service, Magda is assigned to the Berghof, Hitler's mountain retreat. Only after weeks of training does she learn her assignment: she will be one of several young women tasting the Führer's food, offering herself in sacrifice to keep him from being poisoned.

Deep in the tobacco land of North Carolina, nothing's been the same since the boys shipped off to war and worry took their place. Thirteen-year-old Lucy Brown is precocious and itching for adventure. Then Allie Bert Tucker wanders into town, an outcast with a puzzling past, and Lucy figures the two of them can solve any curious crime they find - just like her hero, Nancy Drew. Their chance comes when a man goes missing, a woman stops speaking, and an eccentric gives the girls a mystery to solve that takes them beyond the ordinary.

Ellis Island, 1902. Francesca arrives on the shores of America, her sights set on a better life than the one she left in Italy. That same day, aspiring linguist Alma reports to her first day of work at the immigrant processing center. Ellis, though, is not the refuge it first appears thanks to President Roosevelt's attempts to deter crime. Francesca and Alma will have to rely on each other to escape its corruption and claim the American dreams they were promised.

Three generations of the Brown women travel west together on the Oregon Trail, but each seeks something different. When the trail divides, a decision must be made that could bring survival or tragedy. The challenges faced will form the character of one woman - and impact the future for many more.

As a child, Emma Malloy left isolated Coal River, Pennsylvania, vowing never to return. Now, orphaned and penniless at 19, she accepts a train ticket from her aunt and uncle and travels back to the rough-hewn community. Treated like a servant by her relatives, Emma works for free in the company store. There, miners and their impoverished families must pay inflated prices for food, clothing, and tools while those who owe money are turned away to starve.

Missouri, February 1874: The last thing struggling homesteader Ginny needs is a scandal on her hands. But when a badly injured drifter arrives at Snow Farm in desperate need of medical attention, Ginny’s kind nature and good upbringing means she has no choice but to treat his wounds and care for him until he’s back on his feet, no matter the danger he might pose.

During the Great Depression, labor camps crop up in remote areas throughout the American South. Destitute workers live under terrible conditions. Trapped in these isolated locations, workers are entirely dependent on the often greedy, abusive camp owners who provide food and housing at grossly inflated prices. But for the most desperate among America's vast unemployed, these camps are often the last and only option.

When Andrea moves to Moses Lake, Texas, with her son, she hopes her job will provide purpose and solace from an ordeal that shattered her life and shook her faith. Mart, the new game warden, hopes to escape the constant reminders of a tragedy he can’t forgive himself for. Soon a girl’s plight offers them both a chance for redemption and draws them closer than they ever anticipated.

In the holy city of Tova, the winter solstice is usually a time for celebration and renewal, but this year it coincides with a solar eclipse, a rare celestial even proscribed by the Sun Priest as an unbalancing of the world. Meanwhile, a ship launches from a distant city bound for Tova and set to arrive on the solstice. The captain of the ship, Xiala, is a disgraced Teek whose song can calm the waters around her as easily as it can warp a man’s mind. Her ship carries one passenger.