On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

After years of trying to become pregnant without success, Rachel Dawson and her husband Thomas felt their dreams had finally come true the day they brought home their newly adopted twin babies. Though the lawyer Baron Bell who arranged for the surrogate mother charged a hefty six-figure fee, one glance into the eyes of their precious children told them it was all worth it - until the birth mother reappeared, first demanding more money, then the twins themselves.

Through public triumphs and private sorrows, the men in the Sisters' lives - husbands, friends, colleagues, and lovers - have offered invaluable aid and support. In the process, they've become an informal brotherhood of their own, able to relate to the unique challenges and rewards of life among the vigilantes.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

On the eve of her retirement, Georgia attorney Mikala Aulani is as vivacious and vibrant as ever, eagerly anticipating a happy future with her partner, Ben. But if Kala has learned anything in 35 years of practicing law, it’s that the truth can always surprise you. And when Adam Star turns up at her office, confessing to the long-ago murder of his wife, Kala must return to a notorious case that has never stopped haunting her. Ten years have passed since young nurse Sophie Lee was accused of murdering her wealthy patient.

Olivia Lowell always believed her father's claim that her mother died in childbirth, until the shocking day a lawyer informs her that her mother has just passed away, leaving her a fortune. The money comes with a caveat - and a confession. In her will, Olivia's mother reveals that she and two college friends committed a crime long ago, and now she wants Olivia to track down her accomplices and convince them to come clean.

Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

When Samantha Rainford - newly wed to Douglas Cosmo Rainford III - returns home from her honeymoon to find divorce papers waiting, she's shocked and heartbroken. Then she discovers that she's not the first to be abandoned - she's one of four (or maybe more) ex-Mrs. Rainfords - and decides it's time to put into practice that old truism: Don't get mad, get even.

As far as former NFL star Jake Masters is concerned, dreams are risky propositions. Years ago he came achingly close to achieving his ambition of playing in the Super Bowl - before a spinal injury ended his career. Confined to a wheelchair, unwilling to take a chance on another risky surgery that could restore his mobility, Jake now stays cocooned behind the imposing gates of his lavish home.

Lucy Baker walks away from her high-flying legal career when she successfully defends yet another heinous criminal. Almost a year after her life-changing decision, Lucy has never been happier. Leaving New York City for the suburbs, tending her garden and her dog, Lucy is making future plans with her fiancé, Jonathan St. Clair - and getting acquainted with her neighbors, including the handsome, exasperating one next door, Wylie Wilson....

On his thirty-fifth birthday, Jake St. Cloud inherits a fortune - and learns the whereabouts of his mysterious half-brother. On her deathbed, Selma St. Cloud revealed that Jake had a sibling, a product of his father's affair. At last, Jake is in a position to track down Alex Rosario and make amends for their father's past neglect.

At 29, Alison Marshall is ready to find a place to call home. With no family and no ties, she’s drifted from one small Florida town to another since high school, working odd jobs, saving hard, and building a nest egg. Once she finds the right place to settle down, she’ll know. And when she reaches beautiful Palmetto Island, she thinks she may have found it. The small, close-knit island community seems to have everything Alison needs. On a hunch, she contacts the island’s only realtor, and learns that an old beach house is on the market.

A brilliant career and loving friends weren't enough to heal Dr. Sara Killian's aching heart. For brief, magical moment, world famous rock star Dallas Lord was part of her life. Then he was suddenly and tragically taken away. But before he disappeared, Dallas gave Sara a priceless gift - a beautiful love song written just for her. It's a legacy that will take Sara places she'd never dreamed of - into intrigue, betrayal, and deadly danger.

Professional mountaineer Lily is building a new life for herself - in ways she never would have expected. She's traded the mountain wilderness of Wyoming for the lush river country of the deep South, where she is busy restoring a fine old Natchez, Mississippi house. And she's rediscovered happiness with Matt Starr, the man she has always loved. But Lily's dreams for the future are suddenly threatened when Matt disappears without a trace.

From her silver Mercedes to her designer kitchen, Molly's life is gleaming and beautiful - at least on the surface. Married to Tanner, a top cosmetic dentist, she has a wonderful daughter finishing high school and twin stepsons from Tanner's first marriage. No one in her exclusive neighborhood in Goldenhills, Massachusetts, knows what living with the demanding Tanner is really like. They know even less about the life she left behind in Florida almost two decades ago.