In the turbulent summer of 1974, Kate Mularkey has accepted her place at the bottom of the eighth-grade social food chain. Then, to her amazement, the "coolest girl in the world" moves in across the street and wants to be her friend. Tully Hart seems to have it all - beauty, brains, ambition. On the surface they are as opposite as two people can be: Kate, doomed to be forever uncool, with a loving family who mortifies her at every turn.

For 18 years, Jude Farraday has put her children’s needs above her own, and it shows - her twins, Mia and Zach, are bright and happy teenagers. When Lexi Baill moves into their small, close-knit community, no one is more welcoming than Jude. Lexi, a former foster child with a dark past, quickly becomes Mia’s best friend. Then Zach falls in love with Lexi and the three become inseparable. Jude does everything to keep her kids on track for college and out of harm’s way. It has always been easy - until senior year of high school. Suddenly she is at a loss.

Ani FaNelli seems to have it all: a glamorous job at a glossy magazine, an enviable figure with the wardrobe to match, and a handsome fiancé from a distinguished blue-blood family. But Ani FaNelli is an invention, that veneer of perfection carefully assembled in an attempt to distance herself from a shocking, sordid past.

In 1985, Yale Tishman, the development director for an art gallery in Chicago, is about to pull off an amazing coup, bringing in an extraordinary collection of 1920s paintings as a gift to the gallery. Yet as his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister.

Being the middle child has its ups and downs. But for Grace, an only child who was adopted at birth, discovering that she is a middle child is a different ride altogether. After putting her own baby up for adoption, she goes looking for her biological family, including: Maya, her loudmouthed younger bio sister, who has a lot to say about their newfound family ties. And Joaquin, their stoic older bio brother, who has no interest in bonding over their shared biological mother.

Rachel Blum and Andy Landis are eight years old when they meet late one night in an ER waiting room. Born with a congenital heart defect, Rachel is a veteran of hospitals, and she's intrigued by the boy who shows up all alone with a broken arm. He tells her his name. She tells him a story. After Andy's taken back to the emergency room and Rachel's sent back to her bed, they think they'll never see each other again.

In the spring of 1981, the young Skinner siblings - fierce Renee, dreamy Caroline, golden boy Joe, and watchful Fiona - lose their father to a heart attack and their mother to a paralyzing depression, events that thrust them into a period they will later call “the Pause”. Caught between the predictable life they once led and an uncertain future that stretches before them, the siblings navigate the dangers and resentments of the Pause to emerge fiercely loyal and deeply connected. Two decades later, the Skinners find themselves again confronted with a family crisis....

Two cousins, Rory and Arden, lie unconscious in a hospital burn unit. The fire, which broke out in their shared college dorm room, killed another student, and the police want answers. Tension between Rory and Arden's parents was already at an all-time high before the fire, owing to a recent financial crisis and the decline of the family business. As the parents huddle anxiously in the waiting room, carefully avoiding the subject of their own unraveling relationships, disturbing truths come to light.

He was tall, at least six feet, with dirty blond hair that hung over his eyes. His T-shirt read Nietzsche Is My Homeboy. So, that was Matt. Who Julie Seagles likes. A lot. But there is also Finn. Who she flat out loves. Complicated? Awkward? Completely. But really, how was this freshly-minted Boston transplant and newbie college freshman supposed to know that she would end up living with the family of an old friend of her mother’s? This was all supposed to be temporary.

Dr. Olivia Simon is on duty in the emergency room of North Carolina's Outer Banks Hospital when a gunshot victim is brought in. Midway through the desperate effort to save the young woman's life, Olivia realizes who she is - Annie O'Neill, the woman Olivia's husband, Paul, is in love with.

Helena Conway has fallen in love. Unwillingly. Unwittingly. But not unprovoked. Kit Isley is everything she's not - unstructured, untethered, and not even a little bit careful. It could all be so beautiful...if he wasn't dating her best friend. Helena must defy her heart, do the right thing, and think of others. Until she doesn't.

Lorraine—“Rainy”—lives at the top of Tiger Mountain. Remote, moody, cloistered in pine trees and fog, it’s a sanctuary, a new life. She can hide from the disturbing past she wants to forget. If she’s allowed to. When Rainy reluctantly agrees to a girls’ weekend in Vegas, she’s prepared for an exhausting parade of shots and slot machines. But after a wild night, her friend Braithe doesn’t come back to the hotel room.

Seventeen-year-old Evan Panos doesn't know where he fits in. His strict immigrant Greek mother refuses to see him as anything but a disappointment. His quiet, workaholic father is a staunch believer in avoiding any kind of conflict. And his best friend, Henry, has somehow become distractingly attractive over the summer.

Fifteen years ago, Vida Avery arrived alone and pregnant at elite Fayer Academy. By living on campus, on an island off the New England coast, Vida has cocooned herself and her son, Peter, from the outside world and from an inside secret. For years, she has lived largely through the books she teaches, but when she accepts the impulsive marriage proposal of ardent widower Tom Belou, the prescribed life Vida has constructed is swiftly dismantled.

I’ve been listening to my father sing for my whole life. I carry him in my pocket on my MP3 player. It’s just that we’ve never met face to face. My mother would never tell me how I came to be, or why my rock star father and I have never met. I thought it was her only secret. I was wrong. When she dies, he finally appears. Suddenly I have a first-class ticket into my father’s exclusive world. A world I don’t want any part of - not at this cost. Only three things keep me going: my a cappella singing group, a swoony blue-eyed boy named Jake, and the burning questions in my soul.

Helena Conway has fallen in love. Unwillingly. Unwittingly. But not unprovoked. Kit Isley is everything she's not - unstructured, untethered, and not even a little bit careful. It could all be so beautiful...if he wasn't dating her best friend. Helena must defy her heart, do the right thing, and think of others. Until she doesn't.

Daphne Mitchell has always believed in cause and effect, right and wrong, good and bad. The good: her dream job as a doctor; Owen, her childhood sweetheart and now husband; the beautiful farmhouse they're restoring together. In fact most of her life has been good - until the day Owen comes home early from work to tell her he's fallen head over heels for someone else.

The last time Lex was happy, it was before. When she had a family that was whole. A boyfriend she loved. Friends who didn't look at her like she might break down at any moment. Now she's just the girl whose brother killed himself. And it feels like that's all she'll ever be. As Lex starts to put her life back together, she tries to block out what happened the night Tyler died. But there's a secret she hasn't told anyone--a text Tyler sent that could have changed everything.

Dr. Olivia Simon is on duty in the emergency room of North Carolina's Outer Banks Hospital when a gunshot victim is brought in. Midway through the desperate effort to save the young woman's life, Olivia realizes who she is - Annie O'Neill, the woman Olivia's husband, Paul, is in love with.

Leigh is the mother of high-achieving, popular high school senior Kara. Their relationship is already strained for reasons Leigh does not fully understand when, in a moment of carelessness, Kara makes a mistake that ends in tragedy, the effects of which not only divide Leigh's family, but polarize the entire community.

Two cousins, Rory and Arden, lie unconscious in a hospital burn unit. The fire, which broke out in their shared college dorm room, killed another student, and the police want answers. Tension between Rory and Arden's parents was already at an all-time high before the fire, owing to a recent financial crisis and the decline of the family business. As the parents huddle anxiously in the waiting room, carefully avoiding the subject of their own unraveling relationships, disturbing truths come to light.

Ramona was only five years old when Hurricane Katrina changed her life forever. Since then it's been Ramona and her family against the world. Standing over six feet tall, with unmistakable blue hair, Ramona is sure of three things: She likes girls, she's fiercely devoted to her family, and she knows she's destined for something bigger than the trailer she calls home in Eulogy, Mississippi. But juggling multiple jobs, her flaky mom, and her well-meaning but ineffectual dad forces her to be the adult of the family.

It’s been six years since Pen Calloway watched her best friends walk out of her life. And through the birth of her daughter, the death of her father, and the vicissitudes of single motherhood, she has never stopped missing them. Pen, Cat, and Will met on their first day of college and formed what seemed like a magical and lifelong bond, only to see their friendship break apart amid the realities of adulthood. When, after years of silence, Cat - the bewitching, charismatic center of their group - e-mails Pen and Will with an urgent request to meet at their college reunion, they can’t refuse.

It's been a year since it happened - when Paige Hancock's first boyfriend died in an accident. After shutting out the world for two years, Paige is finally ready for a second chance at high school...and she has a plan. First: Get her old crush, Ryan Chase, to date her - the perfect way to convince everyone she's back to normal. Next: Join a club. But when Ryan's sweet, nerdy cousin, Max, moves to town and recruits Paige for the Quiz Bowl team, her perfect plan is thrown for a serious loop.

Seventeen-year-old Vivian Apple never believed in the evangelical Church of America, unlike her recently devout parents. But when Vivian returns home the night after the supposed 'Rapture,' all that's left of her parents are two holes in the roof. Suddenly, she doesn't know who or what to believe. With her best friend Harp and a mysterious ally, Peter, Vivian embarks on a desperate cross-country road trip through a paranoid and panic-stricken America to find answers.

Seventeen-year-old Jonah Daniels has lived in Verona Cove, California, his whole life, and only one thing has ever changed: His father used to be alive, and now he is not. With a mother lost in a deep bout of depression, Jonah and his five siblings struggle to keep up their home and the restaurant their dad left behind. But at the start of summer, a second change rolls in: Vivi Alexander, the new girl in town.

After grad school, Shay Dixon feels like she's had enough for awhile. Inspired by her spiritual adviser - a soul-soothing blues player named Nina Simon - Shay calls her estranged mother Nona for the first time in years, and shocks herself by asking if it would be okay to come home for a while.

Lilith Whitmore appoints recent empty-nester Wilda to the Rush Advisory Board and suggests their daughters, both incoming freshman, room together. It's all part of Lilith's plan to ensure her own daughter receives an Alpha Delt bid - no matter what. Cali Watkins possesses all the qualities sororities are looking for in a potential new member, but her resume lacks a vital ingredient: pedigree. And if anyone discovers the dark family secrets she's hiding, she'll be dropped from rush in an instant.

Angela is being held in a police interrogation room. Her ex's wife has gone missing, and Detective Novak is sure Angela knows something, despite her claim that she's not involved. At Novak's prodding, Angela tells a story going back 10 years, explaining how she met and fell in love with her high school friend HP. But as her past unfolds, she reveals a disconcerting love triangle and a dark, tangled web of betrayals. Is Angela a scorned ex-lover with criminal intent? Or a pawn in someone else's revenge scheme?

Olivia Kaspen has just discovered that her ex-boyfriend Caleb Drake has lost his memory. With an already lousy reputation for taking advantage of situations, Olivia must decide how far she is willing to go to get Caleb back.