On the surface, these seven women are as different as can be - but each has had her share of bad luck, from cheating husbands to sexist colleagues to a legal system that often doesn't do its job. Now, drawn together by tragedy, they're forging a bond that will help them right the wrongs committed against them and discover an inner strength they didn't know they had. The Sisterhood is learning that when bad things happen, you can roll over and play dead...or you can get up fighting...

After years of trying to become pregnant without success, Rachel Dawson and her husband Thomas felt their dreams had finally come true the day they brought home their newly adopted twin babies. Though the lawyer Baron Bell who arranged for the surrogate mother charged a hefty six-figure fee, one glance into the eyes of their precious children told them it was all worth it - until the birth mother reappeared, first demanding more money, then the twins themselves.

Through public triumphs and private sorrows, the men in the Sisters' lives - husbands, friends, colleagues, and lovers - have offered invaluable aid and support. In the process, they've become an informal brotherhood of their own, able to relate to the unique challenges and rewards of life among the vigilantes.

When Samantha Rainford - newly wed to Douglas Cosmo Rainford III - returns home from her honeymoon to find divorce papers waiting, she's shocked and heartbroken. Then she discovers that she's not the first to be abandoned - she's one of four (or maybe more) ex-Mrs. Rainfords - and decides it's time to put into practice that old truism: Don't get mad, get even.

Teresa "Toots" Amelia Loudenberry has crammed a great deal of living - not to mention eight much-loved husbands - into her varied and rewarding life. Newly single, Toots is ready to taste life again, and fate has just handed her the perfect opportunity.

Mateo Castillo is a rising star chef on the Manhattan culinary scene. But just as he’s about to reap the rewards of his skill and hard work by being featured on a major TV cooking competition, Mateo collapses in his restaurant’s kitchen—and regains consciousness in a hospital emergency room. If it weren’t for a security guard finding him in time, Mateo would have bled to death. The cause of his sudden illness is as mysterious as it is worrying, and Mateo and his family undergo a battery of genetic tests. Yet the answers that start to emerge only raise more questions.

At 29, Alison Marshall is ready to find a place to call home. With no family and no ties, she’s drifted from one small Florida town to another since high school, working odd jobs, saving hard, and building a nest egg. Once she finds the right place to settle down, she’ll know. And when she reaches beautiful Palmetto Island, she thinks she may have found it. The small, close-knit island community seems to have everything Alison needs. On a hunch, she contacts the island’s only realtor, and learns that an old beach house is on the market.

Ellie Bowman barely remembers the incident that put her into a coma. When she awoke, filled with unease, all she knew for certain was that her boyfriend, Rick, was missing. She knew she needed to get away from her old life and recover in safety. With the proceeds of a video game she helped develop, Ellie starts over in rural Missouri, working from her cottage and trusting no one except her friend and business partner.

On the eve of her retirement, Georgia attorney Mikala Aulani is as vivacious and vibrant as ever, eagerly anticipating a happy future with her partner, Ben. But if Kala has learned anything in 35 years of practicing law, it’s that the truth can always surprise you. And when Adam Star turns up at her office, confessing to the long-ago murder of his wife, Kala must return to a notorious case that has never stopped haunting her. Ten years have passed since young nurse Sophie Lee was accused of murdering her wealthy patient.

College senior Lily Madison is on her own and desperate to pay for her last semester of school. With nowhere to turn, she makes the difficult decision to donate her eggs to a fertility clinic. Sam Parker is also a penniless student who supplements his tuition money by visiting a sperm bank. One day, Lily and Sam meet at the clinic and talk about their secret. Despite their obvious attraction, Lily and Sam go their separate ways.

With a heart full of dreams, Sallie Coleman leaves Texas and heads west determined to get as far from the squalor of her dirt poor beginnings. With its shifting sands, smoky saloons, and bingo palaces, Las Vegas seems like a paradise. A paradise where an extraordinary twist of fate makes Sallie the most powerful businesswoman in Nevada.

Tessa Jamison couldn't have imagined anything worse than losing her beloved twin girls and husband - until she was convicted of their murder. For 10 years, she has counted off the days in Florida's Correctional Center for Women, fully expecting to die behind bars. Fighting to prove her innocence holds little appeal now that her family's gone. But on one extraordinary day, her lawyers announce that Tessa's conviction has been overturned due to a technicality, and she's released on bail to await a new trial. Hounded by the press, Tessa retreats to the small tropical island owned by her late husband's pharmaceutical company. There, she begins to gather knowledge about others in similar situations to her own...people who have lost their families in horrific ways, only to see the perpetrators walk away unpunished. For the first time since her nightmare began, Tessa feels a sense of purpose.

Kate and Alex Rocket are blessed with a wonderful marriage and a lovely home. Although Kate is unable to bear children, she and Alex look upon Sara and Emily, affectionate daughters of their good friends Don and Debbie Winter, as part of their family. With one phone call, everything changes. Sara accuses Alex of a heinous act, opening up a vicious rift between the couples. In a single moment an idyllic all-American life has imploded into an unfathomable nightmare. Kate can only watch helplessly as her innocent husband is convicted and sent to prison.

Back in college, Jane Lewis would have given anything to be like homecoming queen Connie Bryan. Instead she was just Plain Jane - overweight, frumpy, and painfully shy. That was then. Today, a lovely and confident Dr. Jane Lewis has a thriving psychotherapy practice, her own radio talk show, a beautiful old Louisiana mansion, and her affectionate, nutty dog, Olive, to keep her company. The only thing missing is someone to share her life.

Josh Coleman left SunStar, the thoroughbred horse farm he'd built from nothing, unfinished when he took to his deathbed. But his family's unfinished business cannot be ignored now that his long-lost daughter has come back to settle an old score. No longer resembling the teenage waif who slipped away in the middle of the night with her illegitimate child 30 years ago, Nealy is rich, sophisticated, and renowned in the racing world-a woman to be reckoned with - and her shocking return changes everything.