The prize-winning and best-selling author of Say Nothing presents a grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

This is the story of the most successful cocaine dealers in the world: Pablo Escobar Gaviria, Jorge Luis Ochoa Vasquez, Carlos Lehder Rivas, and Jose Gonzalo Rodriguez Gacha. In the 1980s, they controlled more than 50 percent of the cocaine flowing into the United States. The cocaine trade is capitalism on overdrive - supply meeting demand on exponential levels. Here you'll find the story of how the modern cocaine business started and how it turned a ragtag group of hippies and sociopaths into regal kings.

In 1929, in the blue-collar city of Portsmouth, Ohio, a company built a swimming pool the size of a football field; named Dreamland, it became the vital centre of the community. Now, addiction has devastated Portsmouth, as it has hundreds of small rural towns and suburbs across America—addiction like no other the country has ever faced. How that happened is the riveting story of Dreamland.

In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched.

Of all the things humans rely on plants for - sustenance, beauty, medicine, fragrance, flavor, fiber - surely the most curious is our use of them to change consciousness: to stimulate or calm, fiddle with or completely alter, the qualities of our mental experience. Take coffee and tea: People around the world rely on caffeine to sharpen their minds. But we do not usually think of caffeine as a drug, or our daily use as an addiction, because it is legal and socially acceptable.

In 1967, during the time of peace, free love, and hitchhiking, 19-year-old Mary Terese Fleszar was last seen walking home to her apartment in Ypsilanti, Michigan. One month later, her naked body stabbed over 30 times and missing both feet and a forearm was discovered on an abandoned farm. A year later, the body of 20-year-old Joan Schell was found, similarly violated. Over the next two years, five more bodies of female students were uncovered around the area.

For 31 years, a monster terrorized the residents of Wichita, Kansas. A bloodthirsty serial killer, self-named "BTK" - for "bind them, torture them, kill them" - he slaughtered men, women, and children alike, eluding the police for decades while bragging of his grisly exploits to the media. The nation was shocked when the fiend who was finally apprehended turned out to be Dennis Rader - a friendly neighbor...a devoted husband...a helpful Boy Scout dad...the respected president of his church. Written by four award-winning crime reporters who covered the story for more than 20 years, Bind, Torture, Kill is the most intimate and complete account of the BTK nightmare

From the New York Times best-selling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair.

Keeping skin healthy is a booming industry, and yet it seems like almost no one agrees on what actually works. What one person says is vital another says is toxic. We have not cured acne or eczema, allergies keep getting worse, and autoimmune conditions are becoming increasingly common. In Clean, doctor and journalist James Hamblin explores how we got here, examining the science and culture of how we care for our skin today.

We are living in a strange world—Salmon calls it “the New Not Normal.” The Phoenix Economy explores the ramifications of the pandemic years, many of which are surprisingly positive. In doing so, Salmon makes sense of one of the most disorienting and devastating events of our lifetimes. He examines the critical aspects of our lives that have been transformed in three parts: Time and Space, Mind and Body, and Business and Pleasure.

She Has Her Mother's Laugh presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it.

If anyone could be considered a Russian counterpart to the infamous British double-agent Kim Philby, it was Oleg Gordievsky. The son of two KGB agents and the product of the best Soviet institutions, the savvy, sophisticated Gordievsky grew to see his nation's communism as both criminal and philistine. He took his first posting for Russian intelligence in 1968 and eventually became the Soviet Union's top man in London, but from 1973 on he was secretly working for MI6.

The dramatic story of the explosive 1894 clash of industry, labor, and government that shook the nation and marked a turning point for America. The Edge of Anarchy offers a vivid account of the greatest uprising of working people in American history. At the pinnacle of the Gilded Age, a boycott of Pullman sleeping cars by hundreds of thousands of railroad employees brought commerce to a standstill across much of the country. Famine threatened, riots broke out along the rail lines. Soon the US Army was on the march and gunfire rang from the streets of major cities.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

In her gripping, necessary, and deeply humane follow-up to the New York Times bestseller Dopesick, journalist Beth Macy brings us to the next frontier of the opioid crisis, telling the story of the everyday heroes fighting to stem the tide of drug overdose in communities that are too often left to fend for themselves, and of the activists and relatives of the dead who are still struggling for accountability in America’s courts. Like the treatment innovators she profiles, Beth Macy meets the opioid crisis where it is—not where we think it should be or wish it was.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

Five years in the making, this brilliant, in-depth investigative reporting on the history, politics, and science of alcoholism will show how AA became our nation's de facto treatment policy, even as evidence for more effective remedies accumulated. US of AA is a character-driven, beautifully written exposé, full of secrecy, irony, liquor industry money, the shrillest of scare tactics and, at its center, a grand deception. US of AA shines a much-needed spotlight on the addiction treatment industry. It will forever change the way we think about the entire enterprise.

Past antidrug campaigns actually encouraged drug use. A few years ago, America stopped dropping acid altogether. The meth epidemic peaked a long, long time ago. NAFTA opened the border and created a bonanza for cocaine and meth traffickers just as President Clinton knew it would. President Reagan may have inadvertently caused the crack epidemic. Kids today are doing fewer illegal drugs than kids from any time in the recent past, and for a surprising reason.

The Panic Virus is a gripping scientific detective story about how grassroots radicals, snake-oil salesmen, and cynical journalists have perpetrated the biggest health-scare hoax of all time. It explores what happens when the media treats all viewpoints as equally valid, regardless of facts, from parents who are convinced that vaccines caused their children's autism to right-wing radicals who believe that climate change is a myth

Scientology, created in 1954 by a prolific sci-fi writer named L. Ron Hubbard, claims to be the world's fastest-growing religion, with millions of members around the world and huge financial holdings. Its celebrity believers keep its profile high, and its teams of "volunteer ministers" offer aid at disaster sites such as Haiti and the World Trade Center. But Scientology is also a notably closed faith, harassing journalists and others through litigation and intimidation, even infiltrating the highest levels of government to further its goals.

In June 2009, Wendell Potter made national headlines with his scorching testimony before the Senate panel on health care reform. This former senior vice president of CIGNA explained how health insurers make promises they have no intention of keeping, how they flout regulations designed to protect consumers, and how they skew political debate with multibillion-dollar public relations campaigns designed to spread disinformation.

This comprehensive and gripping narrative, which received the 2006 Pulitzer Prize for history, covers all the challenges, characters, and controversies in America's relentless struggle against polio. Funded by philanthropy and grassroots contributions, Salk's killed-virus vaccine (1954) and Sabin's live-virus vaccine (1961) began to eradicate this dreaded disease.

Teeth takes listeners on a disturbing journey into America's silent epidemic of oral disease, exposing the hidden connections between tooth decay and stunted job prospects, low educational achievement, social mobility, and the troubling state of our public health.

On a cool, overcast afternoon in April 2016, a salacious tip arrived at the L.A. Times that reporter Paul Pringle thought should have taken, at most, a few weeks to check out: a drug overdose at a fancy hotel involving one of the University of Southern California’s shiniest stars—Dr. Carmen Puliafito, the head of the prestigious medical school. Pringle, who’d long done battle with USC and its almost impenetrable culture of silence, knew reporting the story wouldn’t be a walk in the park. USC is the largest private employer in the city of L.A., and it casts a long shadow.

Dr. Marty Makary is co-developer of the life-saving checklist outlined in Atul Gawande's best-selling The Checklist Manifesto. As a busy surgeon who has worked in many of the best hospitals in the nation, he can testify to the amazing power of modern medicine to cure. But he's also been a witness to a medical culture that routinely leaves surgical sponges inside patients, amputates the wrong limbs, and overdoses children because of sloppy handwriting. Over the last 10 years, neither error rates nor costs have come down, despite scientific progress.

A riveting, powerful telling of the story of the grassroots movement of activists, many of them in a life-or-death struggle, who seized upon scientific research to help develop the drugs that turned HIV from a mostly fatal infection to a manageable disease. Ignored by public officials, religious leaders, and the nation at large, and confronted with shame and hatred, this small group of men and women chose to fight for their right to live by educating themselves and demanding to become full partners in the race for effective treatments.

E. Fuller Torrey's audiobook provides an inside perspective on the birth of the federal mental health program. On staff at the National Institute of Mental Health when the program was being developed and implemented, Torrey draws on his own first-hand account of the creation and launch of the program, extensive research, one-on-one interviews with people involved, and recently unearthed audiotapes of interviews with major figures involved in the legislation. As such, this book provides historical material previously unavailable to the public.

Everyone knows that football is violent and dangerous. But what the players who built the NFL into a $10 billion industry didn’t know—and what the league sought to shield from them—is that no amount of padding could protect the human brain from the force generated by modern football.

Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time - the groundbreaking program to answer the most essential question for humanity: How do we live and die? - and the visionary mastermind behind it.

American society has always been fertile ground for conspiracy theories, but with the election of Donald Trump, previously outlandish ideas suddenly attained legitimacy. Trump himself is a conspiracy enthusiast: from his claim that global warming is a Chinese hoax to the accusations of “fake news”, he has fanned the flames of suspicion. But it was not by the power of one man alone that these ideas gained new power. Republic of Lies looks beyond the caricatures of conspiracy theorists to explain their tenacity.

In 1929, in the blue-collar city of Portsmouth, Ohio, a company built a swimming pool the size of a football field; named Dreamland, it became the vital centre of the community. Now, addiction has devastated Portsmouth, as it has hundreds of small rural towns and suburbs across America—addiction like no other the country has ever faced. How that happened is the riveting story of Dreamland.

The prize-winning and best-selling author of Say Nothing presents a grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched.

American Pain chronicles the rise and fall of this game-changing pill mill and how it helped tip the nation into its current opioid crisis. The narrative, which swings back and forth between Florida and Kentucky, is populated by a diverse cast of characters.

This haunting and propulsive debut follows a journalist's years-long investigation into his father's old classmate: former high school valedictorian Paul Volkman, who seemed destined for greatness after earning his MD and PhD from the prestigious University of Chicago, but is now serving four consecutive life sentences at a federal prison in Arizona.

Pharmaceutical breakthroughs such as antibiotics and vaccines rank among some of the greatest advancements in human history. Yet, exorbitant prices for life-saving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in drug companies. Now, Americans are demanding a national reckoning with a monolithic industry.

Brantt Myhres wasn't around for the birth of his daughter. Myhres had played for seven different NHL teams, and had made millions. But he'd been suspended four times, all for drug use, and he had partied his way out of the league. This is his story, in his own words, of how he fought his way out of minor hockey into the big league, but never left behind the ghosts of a bleak and troubled childhood.

John Kapoor had already amassed a small fortune in pharmaceuticals when he founded Insys Therapeutics. It was the early 2000s, a boom time for painkillers, and he developed a novel formulation of fentanyl, the most potent opioid on the market.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.