Nora Gallagher can begrudgingly admit that she and Gray Ferris are both stellar Philadelphia real estate agents, but that's the beginning and the end of the similarities between them. But when the two women begin to learn that maybe they're not as different as they think, they may finally figure out the most important thing they have in common when it comes to finding a life worth living.

Danielle Clark's life is going according to plan. She's in the middle of her surgical residency and she and her fiance, Will, are the perfect match. At least that's what everyone tells them. When Will brings home a rescue dog, it's hard to tell who's less enthused, Dani or her cat, Jinx. The dog wreaks havoc on the household and needs training, but who has time for that? Certainly not Dani.

Since A-List actress and Hollywood's sweetheart Wren Acker came out, not only is she at the top of the acting world; she's also crush number one for her queer fanbase. Loving life, loving her job, loving her cat-everything is fantastic. Except that lack of any kind of private life. When a car accident brings her to the ER, the bottom falls out of her world when she realizes that reserved Doctor Taylor, her physician, is Madison Taylor from camp way back when she was a kid. And boy, does Madison still hold a well-earned grudge for how that all ended.

High-flying pediatric surgeon Emily Lawrence is new to Washington, DC. Her first week in her new job puts her on a collision course with the most powerful woman in America, President Calvin. Constance "Connie" Calvin's first term is proving turbulent thanks to trying to juggle work and life as a widowed single mother to a twelve-year-old boy. Running for re-election is imminent, and the critics are gunning for her. Worse, her famed icy cool is in danger of melting in the face of Emily's passion, commitment, and charm.

Bailey Kaczmarek has three loves: her dog, her construction company, and her very large family. After she finds out that her fiancée never stopped dating, she resolves to be content with what she has, rather than search for happiness in a relationship. It’s not like she has much free time anyway. Skye Kohl is a high-powered commercial real estate broker, who spends most of her waking hours negotiating some of the largest leases in the nicest buildings in Chicago. She’s so focused on topping the list of the most influential brokers in the city, that she ignores her love life.

Flying-phobic ER nurse Olive Murphy is still gripping the armrest from her first-ever take-off when the pilot announces an in-flight medical emergency. Olive leaps into action and saves a life, but ends up getting stuck in the airport hours away from the marathon she's running in honor of her brother. Luckily for her, Stella Soriano, the stunning type A copilot, offers to give her a ride. After the two spend a magical day together, Stella makes a surprising request: Will Olive be her fake girlfriend?

Hannah Martin has an unusual job: she's a professional cuddler. While she has a big heart for her clients, she hasn't found someone special to snuggle up to in her personal life. Winter Sullivan isn't looking for love. She's an aloof workaholic who's built walls of ice around herself. She would rather drive toothpicks under her fingernails than cuddle, and she certainly doesn't want to share her space with anyone. When Winter's estranged father dies, he leaves her one last surprise: she and Hannah, a perfect stranger, will inherit a building together.

When Cassie Klein goes to an off-campus bar to escape her school’s Family Weekend, she isn’t looking for a hookup—it just happens. Buying a drink for a stranger turns into what should be an uncomplicated, amazing one-night stand. But then the next morning rolls around and her friend drags her along to meet her mom—the hot, older woman Cassie slept with. What should have been a one-time fling quickly proves impossible to ignore, and soon Cassie and Erin are sneaking around. Worst of all, they start to realize they have something real. But is being honest about it worth the cost?

Ellie Beckett's life is simple and uncomplicated; she's on track to become a leading expert in biomedical engineering, she has a pub where she feels comfortable enough to hang out multiple times a week, and so what if she doesn't have time for . . . people? She doesn't need or want them. Until she meets Mia Sharpe. As it turns out, maybe Ellie does want at least one person.

When professional soccer player Alex Grey goes on a vacation to the local South Carolina islands, she isn't anticipating any life-changing events. Just a relaxing weekend to prepare for the upcoming season. But that quickly changes when she finds herself the lone witness to a sailing accident and makes the decision to risk her own life to save a drowning woman—unwittingly coming to the rescue of a US senator's wife, Catharine Cleveland.

Sydney MacKenzie, personal assistant to the rich and famous, is looking forward to a well-earned break to go travelling in her beloved VW camper van, Gertie. That is, until Gertie cries off sick. When her boss calls in a favor, one that will pay Sydney handsomely and put Gertie back on the road, she can’t refuse.

Mac and Jamie had their life together all planned out. Until Jamie did the unforgivable and left Mac for another woman. Twenty years later, they meet again for the first time at a friend’s wedding. Mac’s pain lingers, while Jamie is still haunted by regret.

Eve Marlow has her eyes on the prize: a third season of her popular business makeover show, Do Over. But when her ratings take an unexpected dive, Eve needs a blockbuster new client, or she can kiss season three goodbye. She has her work cut out for her, and that’s before she discovers a litter of newborn kittens in a trash can. Now she’s desperate to find someone to take them so she can concentrate on reviving her career.

Brooks Boseman, born into privilege in an old New Orleans plantation home, could have opted for an easy life just like her siblings, but after a broken heart, she escapes to New York where no one knows her name. A call from the family matriarch changes everything. Her brother Curtis is getting married, and Brooks needs to be at the engagement party. Only she can’t possibly go, not with Curtis set to marry the secret love of her youth, Fallon Goodwin.

Riley, a New York workaholic, has health issues that leave her no choice but to move to a small town to lead a calmer life. She hates the huge mansion she bought on a whim and stands out like a sore thumb in the cheery community of Mystic.