The Carriers
What the Fragile X Gene Reveals About Family, Heredity, and Scientific Discovery
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Narrated by:
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Amy Tallmage
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By:
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Anne Skomorowsky
About this listen
A tiny mutation on the X chromosome can shape a family’s history. Passed down from a “carrier” parent to a child, fragile X syndrome is the most common inherited cause of intellectual disability and autism. Beyond that—and a rarity among genetic disorders—some fragile X carriers not only transmit the mutation, but also experience related conditions themselves. In such cases, carriers can have tremors, infertility, and psychiatric disorders that complicate raising children with fragile X syndrome—and all too often, they suffer in silence.
The Carriers investigates this common but still little-known genetic condition and its life-altering consequences. Anne Skomorowsky reveals how this disorder afflicts families across generations, telling the stories of the mothers and grandparents of fragile X patients and considering how genes interact with family dynamics. She interweaves the personal narratives and family histories of the people affected by fragile X disorders with clear and accessible explanations of the science behind them. Skomorowsky unpacks the latest research on the fragile X mutation and explores the history of its discovery. She highlights the roles of women as carriers, caregivers, and researchers who have made astonishing scientific breakthroughs over the last three decades.
The Carriers is an essential book for fragile X families, including those just learning they are carriers, and for all those interested in the complexities of heredity, the ethical dilemmas of genetic medicine, and the relationship between genes and personality.
©2022 Anne Skomorowsky (P)2022 Audible, Inc.Listeners also enjoyed...
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Story
Every 69 seconds, someone is diagnosed with Alzheimer's disease. Of the top 10 killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer's, an inherited genetic mutation that causes the disease in 100 percent of cases, and has a 50 percent chance of being passed onto the next generation.
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A Cover-to-Cover Slug in the Gut, but Inspiring
- By Gillian on 04-16-17
By: Niki Kapsambelis
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Vagina Obscura
- An Anatomical Voyage
- By: Rachel E. Gross
- Narrated by: Siho Ellsmore
- Length: 10 hrs and 50 mins
- Unabridged
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The Latin term for the female genitalia, pudendum, means “parts for which you should be ashamed”. Until 1651, ovaries were called female testicles. The fallopian tubes are named for a man. Named, claimed, and shamed: Welcome to the story of the female body, as penned by men. Today, a new generation of (mostly) women scientists is finally redrawing the map. With modern tools and fresh perspectives, they’re looking at the organs traditionally bound up in reproduction—the uterus, ovaries, vagina—and seeing within them a new biology of change and resilience.
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poor narration
- By Jane on 08-23-22
By: Rachel E. Gross
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The Spectrum of Hope
- An Optimistic and New Approach to Alzheimer's Disease and Other Dementias
- By: Gayatri Devi MD
- Narrated by: Wendy Tremont King
- Length: 12 hrs and 41 mins
- Unabridged
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Imagine finding a glimmer of good news in a diagnosis of Alzheimer's. And imagine how that would change the outlook of the five million Americans who suffer from Alzheimer's disease and other dementias, not to mention their families, loved ones, and caretakers. A neurologist who's been specializing in dementia and memory loss for more than 20 years, Dr. Gayatri Devi rewrites the story of Alzheimer's by defining it as a spectrum disorder - like autism, Alzheimer's is a disease that affects different people differently.
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Aging with Grace
- By Lisa F on 05-19-21
By: Gayatri Devi MD
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Back to Normal
- Why Ordinary Childhood Behavior Is Mistaken for ADHD, Bipolar Disorder, and Autism Spectrum Disorder
- By: Enrico Gnaulati
- Narrated by: Matthew Kugler
- Length: 8 hrs and 31 mins
- Unabridged
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A veteran clinical psychologist exposes why doctors, teachers, and parents incorrectly diagnose healthy American children with serious psychiatric conditions. In recent years there has been an alarming rise in the number of American children and youth assigned a mental health diagnosis. Current data from the Centers for Disease Control reveal a 41 percent increase in rates of ADHD diagnoses over the past decade and a forty-fold spike in bipolar disorder diagnoses. Similarly, diagnoses of autism spectrum disorder has increased by 78 percent since 2002.
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surprisingly useful and specific
- By SaturdayDad on 03-07-14
By: Enrico Gnaulati
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Crazy Like Us
- The Globalization of the American Psyche
- By: Ethan Watters
- Narrated by: Patrick Lawlor
- Length: 8 hrs and 57 mins
- Unabridged
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America has been the world leader in generating new mental health treatments and modern theories of the human psyche. We export our psychopharmaceuticals packaged with the certainty that our biomedical knowledge will relieve the suffering and stigma of mental illness. We categorize disorders, thereby defining mental illness and health, and then parade these seemingly scientific certainties in front of the world.
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He is a reporter...
- By Briana on 05-07-18
By: Ethan Watters
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Doing Harm
- By: Maya Dusenbery
- Narrated by: Dara Rosenberg
- Length: 13 hrs and 33 mins
- Unabridged
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Editor of the award-winning site Feministing.com, Maya Dusenbery brings together scientific and sociological research, interviews with experts within and outside the medical establishment, and personal stories from women across the country to provide the first comprehensive, accessible look at how sexism in medicine harms women today.
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One of the most important books ever written
- By Dresden on 03-18-18
By: Maya Dusenbery
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- By: Francis S. Collins
- Narrated by: Greg Itzin
- Length: 10 hrs and 45 mins
- Unabridged
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A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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The future of medicine
- By Ronald E on 04-12-10
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The Body Keeps the Score
- Brain, Mind, and Body in the Healing of Trauma
- By: Bessel van der Kolk M.D.
- Narrated by: Sean Pratt
- Length: 16 hrs and 15 mins
- Unabridged
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Trauma is a fact of life. Veterans and their families deal with the painful aftermath of combat; one in five Americans has been molested; one in four grew up with alcoholics; one in three couples have engaged in physical violence. Dr. Bessel van der Kolk, one of the world’s foremost experts on trauma, has spent more than three decades working with survivors. In The Body Keeps the Score, he uses recent scientific advances to show how trauma literally reshapes both body and brain, compromising sufferers’ capacities for pleasure, engagement, self-control, and trust.
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Overall Worthwhile, Lingers Too Long in the Why
- By LittleBeadsOfMercury on 04-07-21
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Counterclockwise
- Mindful Health and the Power of Possibility
- By: Ellen J. Langer
- Narrated by: Sandra Burr
- Length: 7 hrs and 10 mins
- Unabridged
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If we could turn back the clock psychologically, could we also turn it back physically? For more than 30 years, award-winning social psychologist Ellen Langer has studied this provocative question, and now has a conclusive answer: opening our minds to what's possible, instead of clinging to accepted notions about what's not, can lead to better health at any age.
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Surprisingly disappointing
- By Stephen on 06-23-09
By: Ellen J. Langer
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Emotional Intelligence
- By: Daniel Goleman
- Narrated by: Barrett Whitener
- Length: 13 hrs and 32 mins
- Unabridged
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It is the tenth anniversary since the first publication of Daniel Goleman's groundbreaking bestseller, Emotional Intelligence, which maps the territory where IQ meets EQ, where we apply what we know to how we live. Spending over a year on the New York Times bestseller list, Emotional Intelligence provided the evidence for what many successful people already knew: being smart isn't just a matter of mastering facts; it's a matter of mastering your own emotions and understanding the emotions of the people around you.
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Good info, hard to listen sometimes
- By Stephanie on 04-16-03
By: Daniel Goleman
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Unbroken Brain
- A Revolutionary New Way of Understanding Addiction
- By: Maia Szalavitz
- Narrated by: Marisa Vitali
- Length: 12 hrs and 35 mins
- Unabridged
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Challenging both the idea of the addict's "broken brain" and the notion of a simple "addictive personality", Unbroken Brain offers a radical and groundbreaking new perspective, arguing that addiction is a learning disorder, and shows how seeing the condition this way can untangle our current debates over treatment, prevention, and policy.
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Not what I expected
- By Jennifer Sader on 08-28-16
By: Maia Szalavitz
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Brain Rules for Aging Well
- 10 Principles for Staying Vital, Happy, and Sharp
- By: John Medina
- Narrated by: John Medina
- Length: 8 hrs and 38 mins
- Unabridged
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How come I can never find my keys? Why don't I sleep as well as I used to? Why do my friends keep repeating the same stories? What can I do to keep my brain sharp? Scientists know. Brain Rules for Aging Well, by developmental molecular biologist Dr. John Medina, gives you the facts - and the prescription to age well - in his signature engaging style. With so many discoveries over the years, science is literally changing our minds about the optimal care and feeding of the brain. All of it is captivating. A great deal of it is unexpected.
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Scientific and practical
- By symya08 on 04-29-18
By: John Medina
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Saving Normal
- An Insider’s Revolt Against out-of-Control Psychiatric Diagnosis, DSM-5, Big Pharma, and the Medicalization of Ordinary Life
- By: Allen Frances MD
- Narrated by: Paul Boehmer
- Length: 11 hrs and 53 mins
- Unabridged
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In Saving Normal, Allen Frances, one of the world's most influential psychiatrists, warns that mislabeling everyday problems as mental illness has shocking implications for individuals and society: Stigmatizing a healthy person as mentally ill leads to unnecessary, harmful medications, the narrowing of horizons, misallocation of medical resources, and draining of the budgets of families and the nation.
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Right on the money
- By Mentecuerpo on 03-29-19
By: Allen Frances MD
What listeners say about The Carriers
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- MandSWinOK
- 05-17-22
Finally! A book for laymen saying "It's GENETIC!"
Mothers of non-typical kids have been accused of causing their kids' developmental differences due to bad parenting until now. NOW the genetic component of our families' differences is FINALLY being affirmed.
THANK YOU!
...but the excitement with which this sad news is delivered is a bit hard to take. Being different is not JUST fascinating. It's TOUGH!
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- WebSurfr04
- 02-16-23
Enlightening
This book gives you a full perspective on the subject
I enjoyed it and it really helped me understand the syndrome
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- Beast
- 01-30-23
Eye opening
As a pre mutation carrier definitely makes you wonder, opens your eyes about everything. A lot hit home and found to be a read I couldn’t put down.
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- Anonymous User
- 05-26-22
Extremely informative
As a carrier myself this book was so incredibly important. There is so little information about carriers available to the general public, so this culmination of cases and insights is monumental in gaining a deeper understanding of both fragile x permutation and fragile x itself. I have recommend this book to my extended family as well so that they can better understand the implications of carrier status.
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- Marie W
- 03-12-24
Now I understand my condition
I am not a doctor and I needed to understand what it meant to be a carrier and what it meant to the child I am carrying. This book was so helpful at one of the worst time of my life. It gave me the knowledge I did not have to make the best choice for myself and the baby.
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