For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight-how the same simple chemistry gives rise to life and causes our demise.

Robert Sapolsky’s Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but that doesn’t mean it doesn’t exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and in his inimitable way, delightful) full-frontal assault on the pleasant fantasy that there is some separate self telling our biology what to do.

The brain is made up of 85 billion neurons, which are connected by over 100 trillion synapses. For over a century, a diverse array of researchers have been trying to find a language that can be used to capture the essence of what these neurons do and how they communicate - and how those communications create thoughts, perceptions, and actions. The language they were looking for was mathematics, and we would not be able to understand the brain as we do today without it.

Not only can we not currently explain the origin of the universe, it is questionable we will ever be able to explain it. The notion that there are universes within particles, or that particles are conscious, is ascientific, as is the hypothesis that our universe is a computer simulation. On the other hand, the idea that the universe itself is conscious is difficult to rule out entirely.

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

For as long as we’ve studied human cognition, we’ve believed that our senses give us direct access to the world. What we see is what’s really there—or so the thinking goes. But new discoveries in neuroscience and psychology have turned this assumption on its head. What if rather than perceiving reality passively, your mind actively predicts it?

You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.

Language is perhaps humanity’s most astonishing capacity - and one that remains poorly understood. In The Language Game, cognitive scientists Morten H. Christiansen and Nick Chater show us where generations of scientists seeking the rules of language got it wrong. Language isn’t about hardwired grammars but about near-total freedom, something like a game of charades, with the only requirement being a desire to understand and be understood.

The science of emotion is in the midst of a revolution on par with the discovery of relativity in physics and natural selection in biology. Leading the charge is psychologist and neuroscientist Lisa Feldman Barrett, whose research overturns the long-standing belief that emotions are automatic, universal, and hardwired in different brain regions. Instead, Barrett shows, we construct each instance of emotion through a unique interplay of brain, body, and culture.

While cells are commonly considered the building block of living things, it is actually the communication between cells that brings us to life, controlling our bodies and brains, determining whether we are healthy or sick, and directly influencing how we think, feel, and behave. In The Secret Language of Cells, doctor and neuroscientist Jon Lieff lets us listen in on these conversations, and reveals their significance for everything from mental health to cancer.

Oxygen takes the listener on an enthralling journey, as gripping as a thriller, as it unravels the unexpected ways in which oxygen spurred the evolution of life and death.

From the creation of the first encyclopedia to Wikipedia, from ancient museums to modern kindergarten classes—this is Simon Winchester’s brilliant and all-encompassing look at how humans acquire, retain, and pass on information and data, and how technology continues to change our lives and our minds. Throughout this fascinating tour, Winchester forces us to ponder what rational humans are becoming. What good is all this knowledge if it leads to lack of thought? What is information without wisdom?

According to the prevailing scientific paradigm, the universe tends toward randomness; it functions according to laws without purpose, and life is an accident devoid of meaning. Thanks to a new understanding of evolution, as well as recent advances in our understanding of the phenomenon known as emergence, a new cosmic narrative is taking shape: Nature’s simplest “parts” come together to form ever-greater “wholes” in a process that has no end in sight. Bobby Azarian explains the science behind this new view of reality and explores what it means for all of us.

We are in the midst of a global mental health crisis, and mental illnesses are on the rise. But what causes mental illness? And why are mental health problems so hard to treat? Drawing on decades of research, Harvard psychiatrist Dr. Chris Palmer outlines a revolutionary new understanding that for the first time unites our existing knowledge about mental illness within a single framework: mental disorders are metabolic disorders of the brain. Brain Energy will transform the field of mental health, and the lives of countless people around the world.

Why do minds exist? How did mud and stone develop into beings that can experience longing, regret, love, and compassion - beings that are aware of their own experience? Until recently, science offered few answers to these existential questions. Journey of the Mind is the first book to offer a unified account of the mind that explains how consciousness, language, the Self, and civilization emerged incrementally out of chaos.