
The Catalyst
RNA and the Quest to Unlock Life's Deepest Secrets
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Narrated by:
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Joshua Saxon
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By:
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Thomas R. Cech
About this listen
For over half a century, DNA has dominated science and the popular imagination as the "secret of life." But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the center of biology's greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century.
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies may enable us to improve and even extend life beyond nature's current limits.
©2024 Thomas R. Cech (P)2024 HighBridge, a division of Recorded BooksListeners also enjoyed...
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The knowledge of death is so terrifying that we live most of our lives in denial of it. One of the most difficult moments of childhood must be when each of us first realizes that not only we but all our loved ones will die—and there is nothing we can do about it. Or at least, there hasn’t been. Today, we are living through a revolution in biology. Giant strides are being made in understanding why we age—and why some species live longer than others. Could we eventually cheat disease and death and live for a very long time, possibly many times our current lifespan?
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Brilliant. The book was fantastic and level headed. I appreciated also the way he criticized Sinclair.
- By Keto Bro on 04-14-24
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Every Living Thing
- The Great and Deadly Race to Know All Life
- By: Jason Roberts
- Narrated by: David de Vries
- Length: 14 hrs and 2 mins
- Unabridged
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In the eighteenth century, two men—exact contemporaries and polar opposites—dedicated their lives to the same daunting task: identifying and describing all life on Earth. Carl Linnaeus, a pious Swedish doctor with a huckster’s flair, believed that life belonged in tidy, static categories. Georges-Louis de Buffon, an aristocratic polymath and keeper of France’s royal garden, viewed life as a dynamic swirl of complexities. Each began his task believing it to be difficult but not impossible: How could the planet possibly hold more than a few thousand species—or as many could fit on Noah’s Ark?
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Fascinating history of scientific thought
- By Candy Dan on 06-10-24
By: Jason Roberts
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The Billion Dollar Molecule
- One Company's Quest for the Perfect Drug
- By: Barry Werth
- Narrated by: Stephen Bowlby
- Length: 18 hrs and 25 mins
- Unabridged
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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
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Book is interesting but narrator is not
- By Alexa on 05-05-23
By: Barry Werth
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Gene Machine
- The Race to Decipher the Secrets of the Ribosome
- By: Venki Ramakrishnan
- Narrated by: Matthew Waterson
- Length: 8 hrs and 11 mins
- Unabridged
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Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.
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biochemistry+autobiography+science politics
- By Irina Bataeva on 02-15-19
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How We Age
- The Science of Longevity
- By: Coleen T. Murphy
- Narrated by: Rosemary Benson
- Length: 19 hrs and 38 mins
- Unabridged
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All of us would like to live longer, or to slow the debilitating effects of age. In How We Age, Coleen Murphy shows how recent research on longevity and aging may be bringing us closer to this goal. Murphy, a leading scholar of aging, explains that the study of model systems, particularly simple invertebrate animals, combined with breakthroughs in genomic methods, have allowed scientists to probe the molecular mechanisms of longevity and aging.
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Only for Professionals
- By Inga on 04-24-24
By: Coleen T. Murphy
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From One Cell
- A Journey into Life's Origins and the Future of Medicine
- By: Ben Stanger
- Narrated by: Noah James Butler
- Length: 10 hrs and 19 mins
- Unabridged
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Each of us began life as a single cell. From this humble origin, we embarked on a risky journey fraught with opportunities for disaster. Yet, amazingly, we reached our destination intact, emerging as dazzlingly complex, exquisitely engineered assemblages of trillions of cells. This metamorphosis constitutes one of nature's most spectacular yet commonplace magic tricks—and one of its most coveted secrets. In From One Cell, physician and researcher Ben Stanger offers a glimpse into what scientists are discovering about how life and the body take shape.
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great content
- By Amazon Customer on 01-22-24
By: Ben Stanger
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Life Ascending
- The Ten Great Inventions of Evolution
- By: Nick Lane
- Narrated by: Graeme Malcolm
- Length: 13 hrs and 7 mins
- Unabridged
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Where does DNA come from? What is consciousness? How did the eye evolve? Drawing on a treasure trove of new scientific knowledge, Nick Lane expertly reconstructs evolution's history by describing its 10 greatest inventions - from sex and warmth to death - resulting in a stunning account of nature's ingenuity.
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Great and informative but with prior knowledge
- By Joshua on 07-06-10
By: Nick Lane
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Written in Water
- The Ephemeral Life of the Classic in Art
- By: Rochelle Gurstein
- Narrated by: Stephen Graybill
- Length: 20 hrs and 43 mins
- Unabridged
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Is there such a thing as a timeless classic? More than a decade ago, Rochelle Gurstein set out to explore and establish a solid foundation for the classic in the history of taste. To her surprise, that history instead revealed repeated episodes of soaring and falling reputations, rediscoveries of long-forgotten artists, and radical shifts in the canon, all of which went so completely against common knowledge that it was hard to believe it was true.
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Spycraft
- Tricks and Tools of the Dangerous Trade from Elizabeth I to the Restoration
- By: Pete Langman, Nadine Akkerman
- Narrated by: Nan McNamara
- Length: 9 hrs and 2 mins
- Unabridged
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In this engaging, accessible account, Nadine Akkerman and Pete Langman explore the methods spies actually used in the period, including disguises, invisible inks, and even poisons. Drawing on a vast array of archival sources, they show how understanding the tricks and tools of espionage allows us to reimagine well-known stories such as the Babington and Gunpowder plots.
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Needs accompanying PDF
- By Amazon Customer on 09-26-24
By: Pete Langman, and others
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Charge
- Why Does Gravity Rule?
- By: Frank Close
- Narrated by: Perry Daniels
- Length: 5 hrs and 13 mins
- Unabridged
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The charges of the proton and electron are opposite and equal, even though the proton is bigger. But why are they equal? This is one of the deepest unresolved puzzles of physics. Frank Close takes us on a journey into the quantum subatomic world of particles. He describes the strong and weak forces that operate alongside electromagnetism, the color and flavor charges, as well as the parallels between them, giving hints of a deeper unity.
By: Frank Close
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Impossible Monsters
- Dinosaurs, Darwin, and the Battle Between Science and Religion
- By: Michael Taylor
- Narrated by: Michael Langan
- Length: 15 hrs
- Unabridged
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Impossible Monsters reveals the central role of dinosaurs and their discovery in toppling traditional religious authority, and in changing perceptions about the Bible, history, and mankind's place in the world.
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Repetitive and not that interesting
- By Michael on 09-09-24
By: Michael Taylor
What listeners say about The Catalyst
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- James Grogan
- 04-15-25
RNA as catalyst.
The narrative presents a story of biomedical research about complex biomolecules called RNA, following the insights and discoveries of esteemed scientists over the last half century. The story provides some insight into the process of how science occurs, emphasizing progress and the value that RNA holds for medical treatments. The fortuitous and complex aspects of RNA research are outlined as an homage to an exciting sliver of modern biological science. The reading includes many mispronounced words, but otherwise moves along nicely.
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- Auinash Kalsotra
- 09-16-24
Captivating
Highly accessible to non experts. A wonderful weekend read. Will recommend to high school students and teachers
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1 person found this helpful
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- Trebla
- 08-23-24
Among the best at telling the story of science
As a biology major I was aware of much that Cech covers, but with the addition of much I did not know existed about RNA. Perhaps the best part is his descriptions of the visits, talks, papers, friends that actually drive basic science- it is a team sport.
The down mark is for the speaker who just murdered too many well-known bio words- very distracting.
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- Amazon Customer
- 08-14-24
Disappointing
Given the author’s qualifications, I was expecting something way less superficial. It’s also full of dozens of unneeded and unilluminating analogies that largely serve only as a distraction. Also annoying was the increasingly common in audiobooks disclaimer that the narration refers to illustrations/charts that are found only in the paper/e-book versions of this book, instead of actually providing a PDF of those to refer to.
The narration also was disappointing. Among other things, the narrator could’ve spent a few minutes learning how to pronounce the words he was supposed to read. Or someone who actually understood the subject matter should’ve proof-listened to the narration and insisted on corrections. And it’s not just technical/biological terms that he mispronounces. He even mispronounces La Jolla (California), as “la-HOLE-a.” A truly slipshod effort.
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- Anonymous User
- 08-22-24
Disappointing reader!!
The reading is more robotic and most of the information is needless— wish it was more direct and accurate.
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- Mom
- 07-31-24
a discredit to women scientists everywhere
I was so excited to read this book. I pre-ordered the hard copy and the audible version. Midway through chapter one I immediately stopped. I requested a refund for both books and WILL NOT read or recommend it to anyone. Thomas Cech has done a great dishonor to women scientists everywhere. He proudly discussed DNA, Watson and Crick, Kings College with NO mention of Rosalind Franklin, further proving that old, white male scientists go out of their way to discredit women in science.
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1 person found this helpful