
The Catalyst
RNA and the Quest to Unlock Life's Deepest Secrets
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Narrated by:
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Joshua Saxon
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By:
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Thomas R. Cech
About this listen
For over half a century, DNA has dominated science and the popular imagination as the "secret of life." But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the center of biology's greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century.
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies may enable us to improve and even extend life beyond nature's current limits.
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Story
No animal is so entangled in human history as the horse. The thread starts in prehistory, with a slight, shy animal, hunted for food. Domesticating the horse allowed early humans to settle the vast Eurasian steppe; later, their horses enabled new forms of warfare, encouraged long-distance trade routes, and ended up acquiring deep cultural and religious significance.
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The authors love of his material
- By Jim7 on 05-02-25
By: David Chaffetz
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Language City
- The Fight to Preserve Endangered Mother Tongues in New York
- By: Ross Perlin
- Narrated by: Ross Perlin
- Length: 10 hrs and 53 mins
- Unabridged
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Half of all 7,000-plus human languages may disappear over the next century, and when they're gone, it will be forever. Ross Perlin, a linguist and codirector of the Manhattan-based non-profit Endangered Language Alliance, is racing against time to map little-known languages across the most linguistically diverse city in history: contemporary New York.
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Fascinating Read
- By annei on 06-02-24
By: Ross Perlin
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The Billion Dollar Molecule
- One Company's Quest for the Perfect Drug
- By: Barry Werth
- Narrated by: Stephen Bowlby
- Length: 18 hrs and 25 mins
- Unabridged
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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
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Book is interesting but narrator is not
- By Alexa on 05-05-23
By: Barry Werth
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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Impossible Monsters
- Dinosaurs, Darwin, and the Battle Between Science and Religion
- By: Michael Taylor
- Narrated by: Michael Langan
- Length: 15 hrs
- Unabridged
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Impossible Monsters reveals the central role of dinosaurs and their discovery in toppling traditional religious authority, and in changing perceptions about the Bible, history, and mankind's place in the world.
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Repetitive and not that interesting
- By Michael on 09-09-24
By: Michael Taylor
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Charge
- Why Does Gravity Rule?
- By: Frank Close
- Narrated by: Perry Daniels
- Length: 5 hrs and 13 mins
- Unabridged
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The charges of the proton and electron are opposite and equal, even though the proton is bigger. But why are they equal? This is one of the deepest unresolved puzzles of physics. Frank Close takes us on a journey into the quantum subatomic world of particles. He describes the strong and weak forces that operate alongside electromagnetism, the color and flavor charges, as well as the parallels between them, giving hints of a deeper unity.
By: Frank Close
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Life Ascending
- The Ten Great Inventions of Evolution
- By: Nick Lane
- Narrated by: Graeme Malcolm
- Length: 13 hrs and 7 mins
- Unabridged
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Where does DNA come from? What is consciousness? How did the eye evolve? Drawing on a treasure trove of new scientific knowledge, Nick Lane expertly reconstructs evolution's history by describing its 10 greatest inventions - from sex and warmth to death - resulting in a stunning account of nature's ingenuity.
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Great and informative but with prior knowledge
- By Joshua on 07-06-10
By: Nick Lane
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The Epigenetics Revolution
- How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance
- By: Nessa Carey
- Narrated by: Donna Postel
- Length: 11 hrs and 16 mins
- Unabridged
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Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.
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Begins Accessible, Then Becomes Too Technical
- By wbiro on 07-26-17
By: Nessa Carey
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Most Delicious Poison
- The Story of Nature's Toxins―from Spices to Vices
- By: Noah Whiteman
- Narrated by: Noah Whiteman
- Length: 11 hrs and 8 mins
- Unabridged
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Scratch beneath the surface of a coffee bean, a red pepper flake, a poppy seed, a mold spore, a foxglove leaf, a magic-mushroom cap, a marijuana bud, or an apple seed, and we find a bevy of strange chemicals. We use these to greet our days (caffeine), titillate our tongues (capsaicin), recover from surgery (opioids), cure infections (penicillin), mend our hearts (digoxin), bend our minds (psilocybin), calm our nerves (CBD), and even kill our enemies (cyanide). But why do plants and fungi produce such chemicals? And how did we come to use and abuse some of them?
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Off topic
- By Stewart on 12-26-23
By: Noah Whiteman
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Medieval Horizons
- Why the Middle Ages Matter
- By: Ian Mortimer
- Narrated by: Ian Mortimer
- Length: 10 hrs and 23 mins
- Unabridged
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We tend to think of the Middle Ages as a dark, backward, and unchanging time characterized by violence, ignorance, and superstition. By contrast, we believe progress arose from science and technological innovation, and that inventions of recent centuries created the modern world. We couldn't be more wrong.
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Altered my perception of History
- By IowaGreyhound on 06-25-24
By: Ian Mortimer
RNA as catalyst.
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The down mark is for the speaker who just murdered too many well-known bio words- very distracting.
Among the best at telling the story of science
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Captivating
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I have one major complaint, though, about a minor point raised in the closing chapter. In discussing CRISPR he mentions the project to eradicate malaria by eradicating the Aedes aegypti mosquito which transmits the plasmodium parasite. He raises as a serious ethical concern whether this action might have unintended consequences, a la the cane toads introduced to Australia, Kudzu introduced to the American South, etc. These examples he gives are all invasive species which, lacking natural predators, do harm to native ecosystems. But this is not analogous in any way to removing a nuisance species. Yes, this is accomplished by "introducing" the gene-drive males into an endemic mosquito population. But the result isn't out of control growth. Quite the opposite. So shockingly invalid is this comparison that I have a hard time believing it is made in good faith. I think he lazily copied this fallacious argument from a anti-GMO source without even seriously considering it himself.
All about RNA
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The narration also was disappointing. Among other things, the narrator could’ve spent a few minutes learning how to pronounce the words he was supposed to read. Or someone who actually understood the subject matter should’ve proof-listened to the narration and insisted on corrections. And it’s not just technical/biological terms that he mispronounces. He even mispronounces La Jolla (California), as “la-HOLE-a.” A truly slipshod effort.
Disappointing
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Disappointing reader!!
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