
The Catalyst
RNA and the Quest to Unlock Life's Deepest Secrets
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Narrated by:
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Joshua Saxon
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By:
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Thomas R. Cech
About this listen
For over half a century, DNA has dominated science and the popular imagination as the "secret of life." But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the center of biology's greatest mysteries: How did life begin? What makes us human? Why do we get sick and grow old? In The Catalyst, Cech finally brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its very origins to our future in the twenty-first century.
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the aging process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies may enable us to improve and even extend life beyond nature's current limits.
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Where does DNA come from? What is consciousness? How did the eye evolve? Drawing on a treasure trove of new scientific knowledge, Nick Lane expertly reconstructs evolution's history by describing its 10 greatest inventions - from sex and warmth to death - resulting in a stunning account of nature's ingenuity.
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Great and informative but with prior knowledge
- By Joshua on 07-06-10
By: Nick Lane
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The Code Breaker
- Jennifer Doudna, Gene Editing, and the Future of the Human Race
- By: Walter Isaacson
- Narrated by: Kathe Mazur, Walter Isaacson
- Length: 16 hrs and 4 mins
- Unabridged
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The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
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Except for the author, this book is good!
- By Johan on 03-14-21
By: Walter Isaacson
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Why War?
- By: Richard Overy
- Narrated by: Dennis Kleinman
- Length: 10 hrs and 2 mins
- Unabridged
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Why has war been such a consistent presence throughout the human past? A leading historian explains, drawing on rich examples and keen insight. Richard Overy is not the first scholar to take up the title question. In 1931, at the request of the League of Nations, Albert Einstein asked Sigmund Freud to collaborate on a short work examining whether there was "a way of delivering mankind from the menace of war." Published the next year as a pamphlet entitled Why War?, it conveyed Freud's conclusion that the "death drive" made any deliverance impossible.
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War is Peace
- By Anonymous User on 01-23-25
By: Richard Overy
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The Billion Dollar Molecule
- One Company's Quest for the Perfect Drug
- By: Barry Werth
- Narrated by: Stephen Bowlby
- Length: 18 hrs and 25 mins
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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing - atom by atom - both a new life-saving immunosuppressant drug and a drug to combat the virus that causes AIDS.
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Book is interesting but narrator is not
- By Alexa on 05-05-23
By: Barry Werth
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- By: Kevin Davies
- Narrated by: Kevin Davies
- Length: 16 hrs and 17 mins
- Unabridged
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Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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Excellent content, solid execution
- By Samuel Finlayson on 01-25-21
By: Kevin Davies
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Gene Machine
- The Race to Decipher the Secrets of the Ribosome
- By: Venki Ramakrishnan
- Narrated by: Matthew Waterson
- Length: 8 hrs and 11 mins
- Unabridged
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Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.
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biochemistry+autobiography+science politics
- By Irina Bataeva on 02-15-19
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The Secret Life of the Universe
- An Astrobiologist's Search for the Origins and Frontiers of Life
- By: Nathalie A. Cabrol
- Narrated by: Cassandra Campbell
- Length: 9 hrs and 18 mins
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We are living in a golden age in astronomy and in the search for life the universe. Over the last few decades, space exploration has shown that not only are there habitable environments within our solar system, but there are millions of exoplanets within our galaxy that could support life. We are on the cusp of breakthroughs that will revolutionize our understanding of our place in the cosmos in. In The Secret Life of the Universe, astrobiologist and the director of the Carl Sagan Center at the SETI Institute Nathalie A. Cabrol takes us to the frontiers of the search for life.
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Omg insufferably boring cliches
- By John on 08-18-24
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Life as No One Knows It
- The Physics of Life's Emergence
- By: Sara Imari Walker
- Narrated by: Sara Imari Walker
- Length: 7 hrs and 20 mins
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What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.
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Fascinating thought patterns
- By John linden on 09-10-24
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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Why Machines Learn
- The Elegant Math Behind Modern AI
- By: Anil Ananthaswamy
- Narrated by: Rene Ruiz
- Length: 13 hrs and 30 mins
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We are living through a revolution in machine learning-powered AI that shows no signs of slowing down. This technology is based on relatively simple mathematical ideas, some of which go back centuries, including linear algebra and calculus, the stuff of seventeenth- and eighteenth-century mathematics. It took the birth and advancement of computer science and the kindling of 1990s computer chips designed for video games to ignite the explosion of AI that we see today. In this enlightening book, Anil Ananthaswamy explains the fundamental math behind machine learning.
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A great listen, but a physical book is pre appropriate
- By Sameer D. on 11-07-24
What listeners say about The Catalyst
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- James Grogan
- 04-15-25
RNA as catalyst.
The narrative presents a story of biomedical research about complex biomolecules called RNA, following the insights and discoveries of esteemed scientists over the last half century. The story provides some insight into the process of how science occurs, emphasizing progress and the value that RNA holds for medical treatments. The fortuitous and complex aspects of RNA research are outlined as an homage to an exciting sliver of modern biological science. The reading includes many mispronounced words, but otherwise moves along nicely.
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- Auinash Kalsotra
- 09-16-24
Captivating
Highly accessible to non experts. A wonderful weekend read. Will recommend to high school students and teachers
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1 person found this helpful
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- Trebla
- 08-23-24
Among the best at telling the story of science
As a biology major I was aware of much that Cech covers, but with the addition of much I did not know existed about RNA. Perhaps the best part is his descriptions of the visits, talks, papers, friends that actually drive basic science- it is a team sport.
The down mark is for the speaker who just murdered too many well-known bio words- very distracting.
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- Amazon Customer
- 08-14-24
Disappointing
Given the author’s qualifications, I was expecting something way less superficial. It’s also full of dozens of unneeded and unilluminating analogies that largely serve only as a distraction. Also annoying was the increasingly common in audiobooks disclaimer that the narration refers to illustrations/charts that are found only in the paper/e-book versions of this book, instead of actually providing a PDF of those to refer to.
The narration also was disappointing. Among other things, the narrator could’ve spent a few minutes learning how to pronounce the words he was supposed to read. Or someone who actually understood the subject matter should’ve proof-listened to the narration and insisted on corrections. And it’s not just technical/biological terms that he mispronounces. He even mispronounces La Jolla (California), as “la-HOLE-a.” A truly slipshod effort.
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- Anonymous User
- 08-22-24
Disappointing reader!!
The reading is more robotic and most of the information is needless— wish it was more direct and accurate.
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- Mom
- 07-31-24
a discredit to women scientists everywhere
I was so excited to read this book. I pre-ordered the hard copy and the audible version. Midway through chapter one I immediately stopped. I requested a refund for both books and WILL NOT read or recommend it to anyone. Thomas Cech has done a great dishonor to women scientists everywhere. He proudly discussed DNA, Watson and Crick, Kings College with NO mention of Rosalind Franklin, further proving that old, white male scientists go out of their way to discredit women in science.
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1 person found this helpful