Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

On the eve of Newgate Prison's demolition, Watson spies Holmes leaving a public sale of the prison's miscellany in the company of a beautiful stranger, and in possession of an unusual trophy–the death mask of a woman who, more than 20 years earlier, had been executed for the murder of her three children. Holmes agrees to satisfy Watson's curiosity about the memento by recounting the decades-old history of its subject.

More tales from the dispatch box of Doctor John Watson. These 10 stories have appeared previously in various volumes of The MX Book of New Sherlock Holmes Stories and other anthologies. They come together as a collection for the first time.

For all we know, or think we know, about Sherlock Holmes and Doctor Watson, what we don’t know is far, far greater. In the duo’s first case, A Study in Scarlet, we learn that Holmes and Watson met on January 1st, 1881, and subsequently moved into an apartment together at 221b Baker Street. Their first case officially began on March 4th of that year, and it is argued that “The Adventure of the Resident Patient” possibly took place in October of 1881, depending on which version of the story you read. But what happened during the rest of 1881? Or all of 1882?

It's 1906. Far from England, the Ottoman Empire ruled by the despotic Sultan Abd-ul-Hamid 11 is on the verge of imploding. Rival Great Powers, especially Kaiser Wilhelm's Germany, sit watching like crows on a fence, ready to rush in to carve up the vast territories, menacing England's vital overland routes to her Indian possessions. At his medical practice in London's Marylebone, Watson receives a mystifying telegram. It's from Holmes.

In the year 1908, Holmes believed himself to be in retirement. Watson was once again in private practice and unwed. Mrs. Hudson had gone to Sussex to act as Holmes's housekeeper. But the fates had agreed that Martha Hudson and John Watson should be together. Or had they? When Dr. Watson proposes to Martha Hudson, it sets off a series of events that only Sherlock Holmes can deal with. Watson has already had three wives—all have died under unfortunate circumstances. Colm Campbell, Martha Hudson's nephew, thinks there is more here than meets the eye.

On concluding a long day of house calls, Dr. Watson receives an urgent summons to attend his friend, Sherlock Holmes. He arrives at 221B Baker Street to find Holmes in a state of deep shock and wearing scorched clothing that reeks of excrement.

Where Sherlock Holmes tends to go, then surely a crime must be detected. What begins as a chance encounter of a seemingly simple mystery at an Edinburgh home soon takes Holmes and Watson into conflict with the Edinburgh Police, an investigation involving murder and corruption, and crossing paths with the local populace including Dr. Joseph Bell.

From some clear pieces of glass and a raven's feather, the great detective must divine exactly who the client was and what prompted him to seek assistance at 221B. Fortunately, Holmes has a number of experts upon whom he can rely as well as his own vast store of esoteric knowledge. Treading a twisted path, Holmes soon finds himself matching wits with an unseen criminal, who appears to be the equal of the late Professor Moriarty. At the same time, he is tasked with sparing the monarchy any possible embarrassment that may stem from the investigation.

The apparition of a lady dressed in white and long thought dead, a deadly and shadowy form that wreaks terror on the heath, and a figure from the past who has accrued the power to commune with the dead! Here is collection of cases, some new, together with a few old favorites which sorely test Holmes' long-held beliefs to their very limits!

Sherlock Holmes and Doctor Watson are summoned to Theobald Grange, the Warwickshire home of Lady Heminworth. Being of a nervous and superstitious disposition, her Ladyship lives in fear. Her husband and elder son were recently murdered, apparently by the ghost of a court jester who was executed on the site centuries before. The apparition has warned that she, too, is to die. Holmes rejects a supernatural explanation, although his adversary seems unaffected by gunfire and is able to take flight and disappear.

In real life, 221B Baker Street is the home of a bank. When fans send letters to Sherlock Holmes, bank employee Addy Zhuang, known as "Sherlock's Secretary," replies. One day, the bank is robbed, but the thieves only take three letters addressed to Sherlock Holmes. The police conclude it was all a harmless prank, but Addy suspects something more malicious is happening.

When misadventure led a schoolboy in London to employment at Baker Street, few could have guessed where his introduction to Sherlock Holmes would lead. But as the lad matures and he finds himself caught in the middle of a murder investigation, his friendship with Holmes and Watson lures him into the role of detective. 'Billy' documents his experiences, and soon his sleuthing skills not only bring him to another murder, but also lay the foundation for his metamorphosis into a famous mystery writer.

There is a persistent and incorrect idea, reinforced by countless film misrepresentations, that Sherlock Holmes and Dr. Watson were always staid and dull British chaps of middle years (or older), with Holmes a spry, cranky, and impatient eccentric, and Watson a white-haired and portly Boobus Brittanicus, a la Nigel Bruce. Students of the true and Canonical Sherlock Holmes know this to be a falsehood.

Sherlock Holmes thrives on danger. Sudden knife attacks, being stalked, and facing a network of assassins present little more than a cheery break in the monotony. But the enigmatic Lady Beatrice presents danger of a different kind. Is she a murderer or a potential victim? Or something even more perilous? Uncovering her secrets could change Holmes's life forever, and in ways even he cannot anticipate.