When their paths first cross, Ben Livingston is a fledgling screenwriter on the brink of success; Tatum Connelly is a struggling actress tending bar in a New York City dive. They fall in love, they marry, they become parents, and they think only of the future. But as the years go by, Tatum's stardom rises while Ben's fades. In a marriage that bears the fallout of ambition and fame, Ben and Tatum are at a crossroads. Now all they can do is think back....

Twenty years ago, six Penn students shared a house, naively certain that their friendships would endure - until the death of their ringleader and dear friend Bea splintered the group for good. Now, mostly estranged from one another, the remaining five reluctantly gather at that same house on the eve of what would have been Bea's fortieth birthday.

What happens when you think you have it all, and then, suddenly it’s taken away? Willa Chandler-Golden’s father changed the world: with his self-help best seller Is It Really Your Choice? Why Your Entire Life May Be Out of Your Control, millions of devoted fans found solace in the notion that everything happens for a reason. Though Willa isn’t entirely convinced of his prophesies, she readily admits that the universe has delivered her a solid life: a reliable husband, a fast-paced career.

Emme Wynn has wanted nothing more her whole life than to feel like part of a family. Having grown up on the run with her con artist mother, she’s been shuffled from town to town, drawn into bad situations, and has learned some unsavory habits that she’s tried hard to overcome. When her estranged grandmother tracks her down out of the blue and extends a job offer—helping to run her booth at an open-air marketplace in small-town Sweetgrass, Alabama—Emme is hopeful that she’ll finally be able to plant the roots she’s always dreamed of.

Cleo McDougal is a born politician. From congresswoman to senator, the magnetic, ambitious single mother now has her eye on the White House - always looking forward, never back. Until an estranged childhood friend shreds her in an op-ed hit piece gone viral. With seven words - "Cleo McDougal is not a good person" - the presidential hopeful has gone from in control to damage control, and not just in Washington but in life.

Tilly Farmer is 32 and has the perfect life she always dreamed of: married to her high-school sweetheart, working as a guidance counselor in her hometown, trying for a baby. Perfect.... Then, one sweltering afternoon at the local fair, everything changes. Tilly wanders into the fortune tellers tent and is greeted by an old childhood friend, now a psychic, who offers her more than just a reading. "I'm giving you the gift of clarity," her friend says. "It's what I always thought you needed."

Olivia Bender designs exquisite home interiors that satisfy the most demanding clients. But her own deepest desire can’t be fulfilled by marble counters or the perfect rug. She desperately wants to be a mother. Fertility treatments and IVF keep failing. And just when she feels she’s at her lowest point, the police deliver shocking news to Olivia and her husband, Park. DNA results show that the prime suspect in a murder investigation is Park’s son. Olivia is relieved, knowing this is a mistake. Despite their desire, the Benders don’t have any children. Then comes the confession.

For Sewanee Chester, being an audiobook narrator is a long way from her old dreams, but the days of being a star on film sets are long behind her. She’s found success and satisfaction from the inside of a sound booth and it allows her to care for her beloved, ailing grandmother. When she arrives in Las Vegas last-minute for a book convention, Sewanee unexpectedly spends a whirlwind night with a charming stranger.

Little River, New York, 1994: April Sawicki is living in a motorless motorhome that her father won in a poker game. Failing out of school, picking up shifts at a local diner, she’s left fending for herself in a town where she’s never quite felt at home. When she “borrows” her neighbor’s car to perform at an open mic night, she realizes her life could be much bigger than where she came from. After a fight with her dad, April packs her stuff and leaves for good, setting off on a journey to find a life that’s all hers.

Lillie Silva knew life as an empty nester would be hard after her only child left for college, but when her husband abruptly dumps her for another woman just as her son leaves, her world comes crashing down. Besides the fact that this announcement is a complete surprise (to say the least), what shocks Lillie most is that she isn't...heartbroken. She's furious. Lillie has loved her life on Cape Cod, but as a mother, wife and nurse-midwife, she's used to caring for other people...not taking care of herself.

Ainsley O'Leary is so ready to get married - she's even found the engagement ring her boyfriend has stashed away. What she doesn't anticipate is for Eric to blindside her with a tactless breakup he chronicles in a blog - which (of course) goes viral. Devastated and humiliated, Ainsley turns to her half sister, Kate, who's already struggling after the sudden loss of her new husband.

Quinn Maguire has a stable life, a fiancé, and what she thinks is a clear vision for her future. All of that comes undone by her mother’s deathbed confession - the absentee father Quinn spent thirty years resenting is not her real father at all. With that one revealing whisper, Quinn embarks on a journey to Maui, her mother’s childhood home, a storied paradise that holds the truth about her mother’s past and all its secrets Quinn is determined to uncover.

Eve, Justin, Susie, and Ed have been friends since they were teenagers. Now in their thirties, the four are as close as ever, Thursday night bar trivia is sacred, and Eve is still secretly in love with Ed. Maybe she should have moved on by now, but she can’t stop thinking about what could have been. And she knows Ed still thinks about it, too. But then, in an instant, their lives are changed forever.

Who you want people to be makes you blind to who they really are. It’s been a year since Billie Flanagan — a Berkeley mom with an enviable life — went on a solo hike in Desolation Wilderness and vanished from the trail. Her body was never found, just a shattered cellphone and a solitary hiking boot. Her husband and teenage daughter have been coping with Billie’s death the best they can: Jonathan drinks as he works on a loving memoir about his marriage; Olive grows remote, from both her father and her friends at the all-girls school she attends.

Aly Jackson has waited her whole life to become editor in chief of All Good magazine. But six months into the job, she overhears her coworkers belittling her. Aly’s clapback? A very public, career-jeopardizing meltdown. To undo the mess, she agrees to a monthlong unpaid leave. Reluctant but determined to turn misfortune into opportunity, Aly retreats to the Lake Michigan beach house her brother, Luke, left to her when he died nearly a year earlier. Except when Aly arrives, she discovers Luke’s slacker best friend, Wyatt, inherited the place, too.