Between 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by Purdue Pharma’s aggressive marketing of OxyContin. Families, working class and wealthy, have been torn apart, businesses destroyed, and public officials pushed to the brink. Meanwhile, the drugmaker’s owners, Raymond and Mortimer Sackler, whose names adorn museums worldwide, made enormous fortunes from the commercial success of OxyContin.

The opioid epidemic has been described as "one of the greatest mistakes of modern medicine." But calling it a mistake is a generous rewriting of the history of greed, corruption, and indifference that pushed the US into consuming more than 80 percent of the world's opioid painkillers. Journeying through lives and communities wrecked by the epidemic, Chris McGreal reveals not only how Big Pharma hooked Americans on powerfully addictive drugs but the corrupting of medicine and public institutions that let the opioid makers get away with it.

From the New York Times best-selling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair.

In 1929, in the blue-collar city of Portsmouth, Ohio, a company built a swimming pool the size of a football field; named Dreamland, it became the vital centre of the community. Now, addiction has devastated Portsmouth, as it has hundreds of small rural towns and suburbs across America—addiction like no other the country has ever faced. How that happened is the riveting story of Dreamland.

Profanity has always been a deliciously vibrant part of our lexicon, an integral part of being human. In fact, our ability to curse comes from a different part of the brain than other parts of speech - the urgency with which we say "f--k!" is instead related to the instinct that tells us to flee from danger. Language evolves with time, and so does what we consider profane or unspeakable. Nine Nasty Words is a rollicking examination of profanity, explored from every angle: historical, sociological, political, linguistic.

By following the struggle for survival of one small-town hospital, and the patients who walk, or are carried, through its doors, The Hospital takes listeners into the world of the American medical industry in a way no audiobook has done before. Americans are dying sooner, and living in poorer health. Alexander argues that no plan will solve America’s health crisis until the deeper causes of that crisis are addressed.

In 2011, a 26-year-old libertarian programmer named Ross Ulbricht launched the ultimate free market: the Silk Road, a clandestine website hosted on the Dark Web where anyone could trade anything - drugs, hacking software, forged passports, counterfeit cash, poisons - free of the government's watchful eye. It wasn't long before the media got wind of the new website where anyone - not just teenagers and weed dealers but terrorists and black hat hackers - could buy and sell contraband detection-free.

The prize-winning and best-selling author of Say Nothing presents a grand, devastating portrait of three generations of the Sackler family, famed for their philanthropy, whose fortune was built by Valium and whose reputation was destroyed by OxyContin. Empire of Pain is a masterpiece of narrative reporting and writing, exhaustively documented and ferociously compelling.

The definitive investigation and exposé of how some of the nation's largest corporations created and fueled the opioid crisis—from the Pulitzer Prize-winning Washington Post reporters who first uncovered the dimensions of the deluge of pain pills that ravaged the country and the complicity of a near-omnipotent drug cartel.

From blurry vision to crooked teeth, ACLs that tear at alarming rates and spines that seem to spend a lifetime falling apart, it's a curious thing that human beings have beaten the odds as a species. After all, we're the only survivors on our branch of the tree of life. Why is it that human mothers have such a life-endangering experience giving birth? And why are there entire medical specialties for teeth and feet? In this funny, wide-ranging and often surprising book, biologist Alex Bezzerides tells us just where we inherited our achy, brilliant bodies in the process of evolution.

Coffee is an indispensable part of daily life for billions of people around the world - one of the most valuable commodities in the history of global capitalism, the leading source of the world's most popular drug, and perhaps the most widespread word on the planet. Augustine Sedgewick's Coffeeland tells the hidden and surprising story of how this came to be, tracing coffee's 500-year transformation from a mysterious Muslim ritual into an everyday necessity.

Devil Take the Hindmost is a lively, original, and challenging history of stock market speculation from the 17th century to the present day. Edward Chancellor traces the origins of the speculative spirit back to ancient Rome and chronicles its revival in the modern world.

From an award-winning Fortune reporter, an explosive narrative investigation of the generic drug boom that reveals the life-threatening dangers posed by globalization - The Jungle for pharmaceuticals.

Redefining our traditional understanding of the New Deal, Fear Itself finally examines this pivotal American era through a sweeping international lens that juxtaposes a struggling democracy with enticing ideologies like Fascism and Communism. Ira Katznelson, "a towering figure in the study of American and European history" (Cornel West), boldly asserts that, during the 1930s and 1940s, American democracy was rescued yet distorted by a unified band of southern lawmakers who safeguarded racial segregation as they built a new national state to manage capitalism and assert global power.

Crystal methamphetamine is widely considered to be the most dangerous drug in the world, and nowhere is that more true than in the small towns of the American heartland. Methland tells the story of Oelwein, Iowa (pop. 6,159), which, like thousands of other small towns across the country, has been left in the dust by the consolidation of the agricultural industry, a depressed local economy, and an out-migration of people.

When Vonlee "Nicole" Titlow and her aunt, Billie Jean Rogers, came home from a night of gambling in a casino near Detroit, they told police they found Billie's husband unconscious on the floor of the Rogers' mansion. Just another of his alcoholic benders, they assumed. But this time, Donald Rogers didn't wake up.

In 2015, Mary Yoder returned home from the chiropractic center that she operated with her husband, Bill, complaining that she felt unwell. Mary, health-conscious and vibrant, was suddenly vomiting, sweating, and weak. Doctors in the ER and ICU were baffled as to the cause of her rapidly progressing illness. Her loved ones - including Bill and their children, Adam, Tamryn, and Liana - gathered in shock to say good-bye. In the weeks that followed Mary's death, the grief-stricken family received startling news from the medical examiner: Mary had been deliberately poisoned with colchicine.

In the aftermath of a flood that washes away much of a small Tennessee town, evangelical preacher Asher Sharp offers shelter to two gay men. In doing so, he starts to see his life anew - and risks losing everything: his wife, locked into her religious prejudices; his congregation, which shuns Asher after he delivers a passionate sermon in defense of tolerance; and his young son, Justin, caught in the middle of what turns into a bitter custody battle. With no way out but ahead, Asher takes Justin and flees to Key West, where he hopes to find his brother, Luke, whom he'd turned against years ago after Luke came out.

The Mexican drug trade has inspired prejudiced narratives of a war between north and south, White and Brown; between noble cops and vicious kingpins, corrupt politicians and powerful cartels. In this first comprehensive history of the trade, historian Benjamin T. Smith tells the real story of how and why this one-peaceful industry turned violent. He uncovers its origins and explains how this illicit business essentially built modern Mexico, affecting everything from agriculture to medicine to economics - and the country’s all-important relationship with the United States.

A deeply human story, Fentanyl, Inc. is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it.

Two days after Christmas, 2011, Russel Faria returned to his Troy, Missouri, home to find his wife, Betsy, dead, a knife still lodged in her neck. She had been stabbed 55 times in a brutal murder that would set off a chain of events leading to one man's wrongful conviction and imprisonment, another man's death, the revelation of a diabolical scheme, and an astounding miscarriage of justice left unresolved for another 10 years.

While his wife and two-year-old daughter watched TV in the living room, David Poses was in the kitchen, measuring the distance from his index finger to his armpit. He needed to be sure he could pull the trigger with a shotgun barrel in his mouth. Twenty-six inches. Thirty-two years old. More than a decade in a double life fueled by depression and heroin.

Growing up on the Navajo Indian Reservation, David Crow and his siblings idolized their dad. Tall, strong, smart, and brave, the self-taught Cherokee regaled his family with stories of his World War II feats. But as time passed, David discovered the other side of Thurston Crow, the ex-con with his own code of ethics that justified cruelty, violence, lies - even murder. A shrewd con artist with a genius IQ, Thurston intimidated David with beatings to coerce him into doing his criminal bidding. David's mom, too mentally ill to care for her children, couldn't protect him.

Best-selling author Bryan Burrough recently made a shocking discovery: The small town of Temple, Texas, where he had grown up, had harbored a dark secret. One of his high school classmates, Danny Corwin, was a vicious serial killer. In this chilling tale, Burrough raises important questions of whether serial killers can be recognized before they kill or rehabilitated after they do. It is also a story of Texas politics and power that led the good citizens of the town of Temple to enable a demon who was their worst nightmare.

What won't we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine - yes, that strychnine, the one used in rat poison - was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices.