Showing titles in History & Commentary

Nearly two decades after it closed, the South Carolina State Hospital continues to hold a palpable mystique in Columbia and throughout the state. Founded in 1821 as the South Carolina Lunatic Asylum, it housed, fed, and treated thousands of patients incapable of surviving on their own. The patient population in 1961 eclipsed 6,600, well above its listed capacity of 4,823. By the mid-1990s, the patient population had fallen under 700, and the hospital had become a symbol of captivity, horror, and chaos.

In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness. As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety.

The gripping story of a chemical weapons catastrophe, the cover-up, and how one American Army doctor’s discovery led to the development of the first drug to combat cancer, known today as chemotherapy.

Thought of as the seat of our soul, then as a mysteriously animated object, the heart is still more a mystery than it is understood. Why do most animals only get one billion beats? (And how did modern humans get to over two billion - effectively letting us live out two lives?) Why are sufferers of gingivitis more likely to have heart attacks? And what does it really feel like to touch your own heart, or to have someone else's beating inside your chest?

Feeling feverish, tired, or achy? Listening to Gina Kolata's engrossing account of the 1918 Influenza epidemic is sure to give you the chills. A gripping work of science writing, Flu addresses the prospects for a great epidemic recurring, and considers what can be done to prevent it.

Over the past 50 years, rates of autoimmunity and chronic disease have exploded. In this provocative book, Dr. Thomas Cowan argues for a direct causal relationship to a corresponding increase in the number of vaccines American children typically receive. The goal of these vaccines is precisely what we’re now seeing in such abundance among our chronically ill children: the provocation of immune response. Cowan looks at emerging evidence that certain childhood illnesses are actually protective of disease later in life.

In 1930s and 1940s Vienna, child psychiatrist Hans Asperger sought to define autism as a diagnostic category, aiming to treat those children, usually boys, he deemed capable of participating fully in society. Depicted as a compassionate and devoted researcher, Asperger was in fact deeply influenced by Nazi psychiatry. Although he did offer individualized care to children he deemed promising, he also prescribed harsh institutionalization and even transfer to Spiegelgrund for children with greater disabilities, who, he held, could not integrate into the community.

At one time heart disease was a death sentence. By the middle of the 20th century, it was killing millions, and, as with the Black Death centuries before, physicians stood helpless. Visionaries, though, had begun to make strides earlier. On September 7, 1895, Ludwig Rehn successfully sutured the heart of a living man with a knife wound to the chest for the first time.

At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.

The Panic Virus is a gripping scientific detective story about how grassroots radicals, snake-oil salesmen, and cynical journalists have perpetrated the biggest health-scare hoax of all time. It explores what happens when the media treats all viewpoints as equally valid, regardless of facts, from parents who are convinced that vaccines caused their children's autism to right-wing radicals who believe that climate change is a myth

Interweaving history, original reportage, and personal narrative, Pandemic explores the origin of epidemics, drawing parallels between the story of cholera - one of history's most disruptive and deadly pathogens - and the new pathogens that stalk humankind today, from Ebola and avian influenza to drug-resistant superbugs.

Today, astonishing surgical breakthroughs are making limb transplants, face transplants, and a host of other previously undreamed-of operations possible. But getting here has not been a simple story of medical progress. In Blood and Guts, veteran science writer Richard Hollingham weaves a compelling narrative from the key moments in surgical history. We have a ringside seat in the operating theater of University College Hospital in London as world-renowned Victorian surgeon Robert Liston performs a remarkable amputation in 30 seconds - from first cut to final stitch.

This audiobook explores big questions like these, explaining the breakthroughs and discoveries that have shaped our modern-day understanding of medicine and helped us protect and promote our health. Written in plain English, The Medicine Book cuts through the jargon and is packed with pithy explanations of the most important milestones in medical history to untangle knotty concepts.

Plagues upon the Earth is a monumental history of humans and their germs. Weaving together a grand narrative of global history with insights from cutting-edge genetics, Kyle Harper explains why humanity’s uniquely dangerous disease pool is rooted deep in our evolutionary past, and why its growth is accelerated by technological progress. He shows that the story of disease is entangled with the history of slavery, colonialism, and capitalism, and reveals the enduring effects of historical plagues all around us, in patterns of wealth, health, power, and inequality.

He has been called the greatest surgeon of the 20th century. The son of Lebanese immigrants, Michael DeBakey rose from humble beginnings in a backwater Louisiana town to dominate the landscape of modern medicine. His contributions to our understanding and treatment of cardiovascular disease, in particular, were innumerable and epoch-making. DeBakey led a life of high drama, from the streets of Jazz Age New Orleans and the operating theaters of pre-war Europe, to the battlefields of World War II and the floodwaters of Hurricane Katrina.

Ever since the 1918 Spanish influenza pandemic, scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu to the 1924 outbreak of pneumonic plague in Los Angeles to the 1930 "parrot fever" pandemic, through the more recent SARS, Ebola, and Zika epidemics, the last one hundred years have been marked by a succession of unanticipated pandemic alarms.

Sometimes in medicine the only way to know what is truly going on in a patient is to operate, to look inside with one's own eyes. This audio is exploratory surgery on medicine itself, laying bare a science not in its idealized form, but as it actually is - complicated, perplexing, and profoundly human. Atul Gawande offers an unflinching view from the scalpel's edge, where science is ambiguous, information is limited, the stakes are high. In dramatic and revealing stories of patients and doctors, he explores how deadly mistakes occur and why good surgeons go bad.

The "absorbing and powerful" (Wall Street Journal) story of two pioneering suffragette doctors who shattered social expectations and transformed modern medicine during World War I. In No Man's Land, Wendy Moore illuminates this turbulent moment of global war and pandemic when women were, for the first time, allowed to operate on men. Their fortitude and brilliance serve as powerful reminders of what women can achieve against all odds.

To these seven narratives of neurological disorder Dr. Sacks brings the same humanity, poetic observation, and infectious sense of wonder that are apparent in his bestsellers Awakenings and The Man Who Mistook His Wife for a Hat. These men, women, and one extraordinary child emerge as brilliantly adaptive personalities, whose conditions have not so much debilitated them as ushered them into another reality.

Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type - from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope....