When Abraham Verghese, a physician whose marriage is unraveling, relocates to El Paso, Texas, he hopes to make a fresh start as a staff member at the county hospital. There he meets David Smith, a medical student recovering from drug addiction, and the two men begin a tennis ritual that allows them to shed their inhibitions and find security in the sport they love and with each other. This friendship between doctor and intern grows increasingly rich and complex, more intimate than two men usually allow.

Eighteen-year-old Eva Yin is admitted into an ER in the San Francisco Bay Area for a serious blood infection - the souvenir of a missed shot of heroin. Barely recovered and against medical advice, she leaves the hospital for New York City only to end up homeless and facing prostitution and violence. Being a heroin addict is like running in circles. You run, and you run, and you end up exactly where you started.

Jude Hassan was an ordinary, all-American kid. He had two amazing parents who gave him everything, especially a loving home. At fourteen, Jude's family moved from their home in the city to a beautiful suburban town on the outskirts of St. Louis. Suddenly, Jude was faced with being the new kid for the first time in his young life. He struggled to find his way in his new surroundings but continued to make straight A’s and excel in sports. When a fellow student approached him about attending a party, he was apprehensive but eager to experience his first social gathering. Unfortunately, that ...

As Melissa Bond raises her infant daughter and a special-needs one-year-old son, she suffers from unbearable insomnia, sleeping an hour or less each night. She loses her job as a journalist (a casualty of the 2008 recession), and her relationship with her husband grows distant. Her doctor casually prescribes benzodiazepines—a family of drugs that includes Xanax, Valium, Klonopin, Ativan—and increases her dosage regularly.

Journalist Jenny Valentish investigates the female experience of drugs and alcohol, using her own story to light the way. Mining the expertise of leading researchers, she explores the early predictors of addiction, such as childhood trauma and temperament, and teenage impulsivity. Drawing on neuroscience, she explains why other self-destructive behaviours - such as eating disorders and high-risk sex - are interchangeable with substance use.