The Creative Destruction of Medicine
How the Digital Revolution Will Create Better Health Care
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Narrated by:
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Dick Hill
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By:
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Eric Topol
About this listen
Until very recently, if you were to ask most doctors, they would tell you there were only two kinds of medicine: the quack kind, and the evidence-based kind. The former is baseless, and the latter based on the best information human effort could buy, with carefully controlled double-blind trials, hundreds of patients, and clear indicators of success. Well, Eric Topol isn't most doctors, and he suggests you entertain the notion of a third kind of medicine, one that will make the evidence-based state-of-the-art stuff look scarcely better than an alchemist trying to animate a homunculus in a jar.
It turns out that plenty of new medicines - although tested with what seem like large trials - actually end up revealing most of their problems only once they get out in the real world, with millions of people with all kinds of conditions mixing them with everything in the pharmacopeia. The unexpected interactions of drugs, patients, and diseases can be devastating. And the clear indicators of success often turn out to be minimal, often as small as one fewer person dying out of a hundred (or even a thousand), and often at exorbitant cost.
How can we avoid these dangerous interactions and side-effects? How can we predict which person out of a hundred will be helped by a new drug, and which fatally harmed? And how can we avoid having to need costly drugs in the first place? It sure isn't by doing another 400-person trial.
As Topol argues in The Creative Destruction of Medicine, it's by bringing the era of big data to the clinic, laboratory, and hospital, with wearable sensors, smartphone apps, and whole-genome scans providing the raw materials for a revolution. Combining all the data those tools can provide will give us a complete and continuously updated picture of every patient, changing everything from the treatment of disease, to the prolonging of health, to the development of new treatments. As revolutionary as the past 20 years in personal technology and medicine have been - remember phones the sizes of bricks that only made calls, or when the most advanced "genotyping" we could do involved discerning blood types and Rh-factors? - Topol makes it clear that we haven't seen a thing yet. With an optimism matched only by a realism gained through 25 years in a tough job, Topol proves the ideal guide to the medicine of the future - medicine he himself is deeply involved in creating.
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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In to the abyss we ascend, a scary future
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A Nation in Pain
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Published in partnership with the International Association for the Study of Pain, A Nation in Pain offers a sweeping, deeply researched account of the chronic pain crisis, from neurobiology to public policy, and presents practical solutions that are within our grasp today. Drawing on both her personal experience with chronic pain and her background as an award-winning health journalist, she guides us through recent scientific discoveries, including genetic susceptibility to pain.
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Broad but superficial.
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The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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Are you one of the 82 million Americans currently diagnosed with cardiovascular disease - or one of the millions more who think they are healthy but are at risk? Whether your goal is to get the best treatment or to stay out of the cardiologist’s office, your heart’s health depends on accurate information and correct answers to key questions. In Heart 411 two renowned experts, heart surgeon Marc Gillinov and cardiologist Steven Nissen, tackle the questions their patients have raised over decades....
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The human brain is perhaps the most powerful and mysterious arrangement of matter in the known universe. New discoveries that unravel this mystery and let us tap into this power offer almost limitless potential - the ability to reshape ourselves and our thought processes, to improve our health and extend our lives, and to enhance and augment the ways we interact with the world around us. In The NeuroGeneration, award-winning inventor Tan Le explores exciting advancements in brain science and neurotechnology that are revolutionizing the way we think, work, and heal.
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Chock full of eye opening information!
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Editor of the award-winning site Feministing.com, Maya Dusenbery brings together scientific and sociological research, interviews with experts within and outside the medical establishment, and personal stories from women across the country to provide the first comprehensive, accessible look at how sexism in medicine harms women today.
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One of the most important books ever written
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American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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Eye opening introduction to biomedical R&D
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One out of three women alive today, and one out of two men, will face a cancer diagnosis, according to the World Health Organization. Ty Bollinger takes this personally: in the course of a decade, he says, "I lost my entire family to cancer. I don't believe I had to lose them." The Truth about Cancer has been written for one simple reason: to share the knowledge we need to protect ourselves, treat ourselves, and in some cases save our lives or the lives of those we love.
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save a life with this valuable information.
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The hazards of electronic pollution may once have been the stuff of science fiction, but now we know they're all too real. And with the advent of 5G ultra-wideband technology, the danger is greater than ever. Dr. Joseph Mercola, one of the world's foremost authorities on alternative health, has mined the scientific literature to offer a radical new understanding of how electromagnetic fields impact your body and mind.
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Top 10 best books ever
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New Yorker staff writer Michael Specter has twice won the Global Health Council’s Excellence in Media Award, as well as the Science Journalism Award from the American Association for the Advancement of Science. In Denialism, he fervently argues that people are turning away from new technologies and engaging in a kind of magical thinking that is hindering scientific progress.
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A compelling read
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Influenza
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On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
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Important read
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Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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Excellent content, solid execution
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The Problem of Alzheimer's
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In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. Sixteen million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their 70s and 80s, the number of patients will rise to an estimated 13.8 million by 2025. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis.
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A must read
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What listeners say about The Creative Destruction of Medicine
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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- Lynn
- 04-17-12
A Rx Prediction for Health Care
The US is behind a number of countries when it comes to use of medical information technology (IT). Physicians in the US have been notorious for being late adaptors of new technology and IT. Eric Topol, MD, in his book The Creative Destruction of Medicine, addresses issues surrounding the digital revolution and building the health system of the future. This is a thoughtful, intelligent book which walks the novice through what is possible, the tests and images available, what is to potentially come into wide use, and why we should care. There is a tipping point (my term) on the horizon that will change health care in the USA forever. The digital revolution that is turning higher education upside down, revolutionizing the retail sector, and upending banking and finance is on the cusp of changing how we maintain wellness in the country. Negatively, Topol allocates long passages to genetic decoding, imaging, and other methodology. That can be very interesting to general readers, but I really wanted more information and speculation about what is to come as a result of digital influence on the practice of medicine. Some parts of the books are a little, but then I am a grown up and benefit without being entertained. I don’t mind “lots of words and no pictures.” The Dick Hill reading is very good.
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5 people found this helpful
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- richie rich & the deuterostomes
- 01-25-15
Very interesting, but in someways very naive.
Where does The Creative Destruction of Medicine rank among all the audiobooks you’ve listened to so far?
Dr. Topol presents a very lively, and optimistic view of medicine and patterns that may advance it in the near future. The optimism espoused is very heavily dependent on technological advances (which is in many ways understandable), but the author doesn't address how to rid ourselves of our terrible health care delivery system. The role of non-scientists and non-clinical care givers in our current system.
What was one of the most memorable moments of The Creative Destruction of Medicine?
The ridiculous amount of bureaucracy organizations like the FDA represent, and still how many times corners get cut on the road to approval when the applicant has the money to pay.
The ridiculous concept of surrogate endpoints, and misleading statistics.
Was this a book you wanted to listen to all in one sitting?
No, I went a referred to some sources that Dr. Topol mentioned and I took a circuitous path.
Any additional comments?
Interesting points throughout the book, but also very disturbing that the health care industry has little resemblance to evidence based medicine.
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2 people found this helpful
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- salt_doll
- 07-13-17
Fantastic read for everyone in healthcare
Dr Topol talks about the practice of medicine in United States and how outdated it is and how advances in genomics, technology, digital monitoring are largely left out. He also gives a comprehensive overview of all of the above with lot of references and examples. I listened to it on my daily commute so it was impactful. I can imagine it getting a bit tedious for a reader.
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- Thomas Graham
- 03-27-21
Eric Topols insight into medicines future
Dr Topol describes a vision for medicine 10 years ago which is ironically coming into being because of an enormous population based disaster, COVID SARS2.
He argues against population based medicine assuming that large clinical trials do not target the correct patients, and genetics could facilitate that target. One would have to accept that the more we know about our genetic background, population medicine is NOT just intervention. We’re it not for our large investigative population based epidemiological studies many of our diseases would have taken years longer to assess causal associations. That said, treating whole populations for the protection of the few does not make sense and genotyping, as he proposes, is a very appropriate way to target intervention and perhaps drug development.
As a large proponent of big data, I would suggest Dr Topol is also advocating for large population based studies to sort through multi factorial health issues to look at best ways to ameliorate global health.
The book is very worthwhile reading/listening to and his insight from a decade before is prescient.
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- P Branson Summers
- 11-16-16
informative, but dry
enjoyed it for the most part, but somewhat dry. lots of science, very informative and enlightening
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- barbara sherry
- 08-24-24
Understanding healthcare causes is complicated
Dr. Topol synthesized the background of an amazing amount solvable healthcare structural issues in a very understandable way. I loved it.
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- Andy
- 03-05-14
glimpse into a better future...maybe
Fascinating survey of how technology is fueling positive changes in healthcare. Eric Topol provides a clear view of the path forward, along with the obstacles that need to be overcome. While it won't happen soon enough for many people, positive change is on the way.
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1 person found this helpful
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- Talia
- 05-21-14
Poor plot orginization
Would you try another book from Eric Topol and/or Dick Hill?
no
What was most disappointing about Eric Topol’s story?
It was a long list of new things in medicine poorly organized into a book
How could the performance have been better?
He could have read the book at a normal pace instead of the slowest reading ever in a poor attempt to make the book seem longer
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- Ricky
- 04-29-13
Not at all about The Digital Revolution
This book is for the most part a rant on the inadequacies of medical science. If I wanted a book on that subject I would have bought one.
I wanted a book that goes in depth on how the digital revolution is making health care better.
A very negative book too, just keeps on complaining over and over.
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1 person found this helpful
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- Mini girl
- 01-05-17
Narrator kills it
This may well be a great book but I just couldn't tolerate the narrator's 1950's melodramatic newscaster reading style. Didn't even get to the end of the first chapter.
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