Showing titles in History & Commentary

In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look down their hand-made microscopes. What they see introduces a radical concept that sweeps through biology and medicine, touching virtually every aspect of the two sciences and altering both forever. It is the fact that complex living organisms are assemblages of tiny self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christens them "cells".

During the worst smallpox epidemic in Boston history, Mather convinced Doctor Boylston to try a procedure that he believed would prevent death - by making an incision in the arm of a healthy person and implanting it with smallpox. "Inoculation" led to vaccination, one of the most profound medical discoveries in history.

Drawing on scholarship in the rhetoric of health and medicine, the health and medical humanities, and related fields, Derkatch offers a nuanced account of how language, belief, behavior, experience, and persuasion collide to produce and promote wellness, one of the most compelling and harmful concepts that govern contemporary Western life.

For 4,000 years, the size and vitality of cities, economies, and empires were heavily determined by infection. Striking humanity in waves, the cycle of plagues set the tempo of civilizational growth and decline, since common response to the threat was exclusion — quarantining the sick or keeping them out. But the unprecedented hygiene and medical revolutions of the past two centuries have allowed humanity to free itself from the hold of epidemic cycles — resulting in an urbanized, globalized, and unimaginably wealthy world.

Few diseases are more gruesome than typhus. Transmitted by body lice, it afflicts the dispossessed - refugees, soldiers, and ghettoized peoples - causing hallucinations, terrible headaches, boiling fever, and often death. The disease plagued the German army on the Eastern Front and left the Reich desperate for a vaccine. For this they turned to the brilliant and eccentric Polish zoologist Rudolf Weigl.

For centuries, people have talked of a powerful bodily disorder called migraine, which currently affects about a billion people around the world. Yet until now, the rich history of this condition has barely been told. In Migraine, award-winning historian Katherine Foxhall reveals the ideas and methods that ordinary people and medical professionals have used to describe, explain, and treat migraine since the Middle Ages.

In The Invention of the Modern Dog, Michael Worboys, Julie-Marie Strange, and Neil Pemberton explore when, where, why, and how Victorians invented the modern way of ordering and breeding dogs. Though talk of "breed" was common before this period in the context of livestock, the modern idea of a dog breed defined in terms of shape, size, coat, and color arose during the Victorian period in response to a burgeoning competitive dog show culture.

Each of us will know physical pain in our lives, but none of us knows when it will come or how long it will stay. Today as much as 10 percent of the population of the United States suffers from chronic pain. It is more widespread, misdiagnosed, and undertreated than any major disease. While recent research has shown that pain produces pathological changes to the brain and spinal cord, many doctors and patients still labor under misguided cultural notions and outdated scientific dogmas.

At the turn of the last century, a smallpox epidemic swept the United States. The age-old disease spread swiftly through an increasingly interconnected American landscape: from southern plantations to the immigrant neighborhoods of northern cities to far-flung villages on the edges of the American empire. In Pox, historian Michael Willrich offers a gripping chronicle of how the nation's continent-wide fight against smallpox launched one of the most important civil liberties struggles of the 20th century.

An estimated 10 percent of Americans are implanted with medical devices - like pacemakers, artificial hips, cardiac stents, etc. The overwhelming majority of high-risk implanted devices have never undergone a single clinical trial. The FDA lets device manufacturers decide whether to report serious complications or deaths that may have been caused by their products. Here, award-winning journalist Jeanne Lenzer brings these horrifying statistics to life through the story of one working-class man who, after his "cure" nearly kills him, ends up in a battle for justice.

The second-century Greek physician Galen—the most famous doctor in antiquity after Hippocrates—is a central figure in Western medicine. A talented doctor, surgeon, writer, philosopher, teacher, pharmacologist, and inventor, Galen attended the court of Marcus Aurelius, living through outbreaks of plague that devastated the Roman Empire. He also served as a physician for professional gladiators. In writings that provided the foundation of Western medicine up to the nineteenth century, Galen created a unified account of health and disease.

In Chasing the Intact Mind, Lutz traces the history of the intact mind concept, explaining how it influences current policy and practice affecting those with autism.

Detrás de cada fármaco se esconde una historia. Puede ser la de un investigador excéntrico que resultó ser un genio, un momento decisivo en la historia geopolítica, un nuevo avance tecnológico o un inesperado pero afortunado efecto secundario descubierto en un ensayo clínico. A través de datos curiosos, anécdotas poco conocidas y personajes un tanto extravagantes, Thomas Hager propone un recorrido por las diez drogas más significativas de la historia a la vez que muestra la evolución de nuestra cultura y práctica de la medicina.

In this ground-breaking history Elinor Cleghorn unpacks the roots of the perpetual misunderstanding, mystification and misdiagnosis of women's bodies, illness and pain. From the 'wandering womb' of ancient Greece to today's shifting understanding of hormones, menstruation and menopause, Unwell Women is the revolutionary story of women who have suffered, challenged and rewritten medical misogyny. Drawing on Elinor's own experience as an unwell woman, this is a powerful and timely exposé of the medical world and woman's place within it.

Based on extensive research into the business records of mountain entrepreneurs, country stores, and pharmaceutical companies, Ginseng Diggers: A History of Root and Herb Gathering in Appalachia is the first book to unearth the unique relationship between the Appalachian region and the global trade in medicinal plants. Historian Luke Manget expands our understanding of the gathering commons by exploring how and why Appalachia became the nation’s premier purveyor of botanical drugs in the late-nineteenth century.

Now more than 133 million Americans live with chronic illness, accounting for nearly three-quarters of all health care dollars, and untold pain and disability. There has been an alarming rise in illnesses that defy diagnosis through clinical tests or have no known cure. Millions of people, especially women, with illnesses such as irritable bowel syndrome, chronic pain, and chronic fatigue syndrome face skepticism from physicians and the public alike.

One hundred years after a milestone medical discovery, Insulin: The Crooked Timber tells the story of how insulin was transformed from what one clinician called "thick brown muck" into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune. Taking the listener on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, the book reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes.

When a waiting world learned on April 12, 1955, that Jonas Salk had successfully created a vaccine to prevent poliomyelitis, he became a hero overnight. Born in a New York tenement, humble in manner, Salk had all the makings of a 20th-century icon - a knight in a white coat. In the wake of his achievement, he received a staggering number of awards and honors; for years his name ranked with Gandhi and Churchill on lists of the most revered people.

With a death toll of between 50 and 100 million people and a global reach, the Spanish flu of 1918–1920 was the greatest human disaster. And yet, in our popular conception it exists largely as a footnote to World War I. Laura Spinney recounts the story of an overlooked pandemic, tracing it from Alaska to Brazil, from Persia to Spain and from South Africa to Odessa. She shows how the pandemic was shaped by the interaction of a virus and the humans it encountered, and how this devastating natural experiment put both the ingenuity and the vulnerability of humans to the test.

A vibrant young Hispano woman, Shonnie Medina, inherits a breast-cancer mutation known as BRCA1.185delAG. It is a genetic variant characteristic of Jews. The Medinas knew they were descended from Native Americans and Spanish Catholics, but they did not know that they had Jewish ancestry as well. The mutation most likely sprang from Sephardic Jews hounded by the Spanish Inquisition. The discovery of the gene leads to a fascinating investigation of cultural history and modern genetics by Dr. Harry Ostrer and other experts on the DNA of Jewish populations.