An unidentified nude female sits propped against a fountain in Central Park. There are no signs of struggle. When Dr. Kay Scarpetta and her colleagues Benton Wesley and Pete Marino arrive on the scene, they instantly recognize the signature of serial killer Temple Brooks Gault. Scarpetta, on assignment with the FBI, visits the New York City morgue on Christmas morning, where she must use her forensic expertise to give a name to the nameless—a difficult task. But as she sorts through conflicting forensic clues, Gault claims his next victim.

Forensic pathologist Dr. Kay Scarpetta has come almost full circle, returning to Virginia, the state where she launched her storied career, as the chief medical examiner. Finding herself the new girl in town once again after being away for many years, she’s inherited both an overbearing secretary and a legacy of neglect and potential corruption.

A Massachusetts state investigator is called home from Knoxville, Tennessee, where he is completing a course at the National Forensic Academy. His boss is planning to run for governor, and as a showcase she's planning to use a new crime initiative called At Risk; its motto: "Any crime, any time." In particular, she's been looking for a way to employ cutting-edge DNA technology, and she thinks she's found the perfect subject in an unsolved 20-year-old murder-in Tennessee.

Vain and charismatic Walter Sickert made a name for himself as a painter in Victorian London. But the ghoulish nature of his art - as well as extensive evidence - points to another name, one that's left its bloody mark on the pages of history: Jack the Ripper. Cornwell has collected never-before-seen archival material - including a rare mortuary photo, personal correspondence and a will with a mysterious autopsy clause - and applied cutting-edge forensic science to open an old crime to new scrutiny.

In this first title of a new mystery series, Cornwell introduces us to a dynamic trio of crime solvers in Charlotte, North Carolina: Andy Brazil, an eager young reporter; Judy Hammer, the city's police chief; and Virginia West, Hammer's deputy and a genuine head turner. They're after a serial killer who pulls male out-of-towners from their rental cars and then mutilates, spray paints, and shoots them, in that order. What the trio uncovers jolts them like the sting of the hornet - Charlotte's symbol.