The knowledge of death is so terrifying that we live most of our lives in denial of it. One of the most difficult moments of childhood must be when each of us first realizes that not only we but all our loved ones will die—and there is nothing we can do about it. Or at least, there hasn’t been. Today, we are living through a revolution in biology. Giant strides are being made in understanding why we age—and why some species live longer than others. Could we eventually cheat disease and death and live for a very long time, possibly many times our current lifespan?

A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

The hunt for the holy grail of healthy aging has been ongoing for hundreds of years, and Dr. Stephanie Venn-Watson may be its most unlikely champion. As a veterinary epidemiologist, she was recruited by the US Navy to lead a clinical research program to improve the health of Navy dolphins. Using advanced biotechnology to study the healthiest aging dolphins, she discovered C15:0, a saturated fat which has the potential to expand both the health-span and lifespan in long-lived mammals.

Conflict is increasing everywhere, threatening everything we hold dear—from our families to our democracy, from our workplaces to our world. In nearly every area of society, we are fighting more and collaborating less, especially over crucial problems that demand solutions. With this groundbreaking book, bestselling author and international negotiator William Ury shares a new “path to possible”—time-tested practices that will help listeners unlock their power to constructively engage and transform conflict.

What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.

In Waves in an Impossible Sea, physicist Matt Strassler tells a startling tale of elementary particles, human experience, and empty space. He begins with a simple mystery of motion. When we drive at highway speeds with the windows down, the wind beats against our faces. Yet our planet hurtles through the cosmos at 150 miles per second, and we feel nothing of it. How can our voyage be so tranquil when, as Einstein discovered, matter warps space, and space deflects matter? The answer, Strassler reveals, is that empty space is a sea, albeit a paradoxically strange one.

Vince Beiser explores the Achilles’ heel of “green power” and digital technology–that manufacturing computers, cell phones, electric cars, and other technologies demand skyrocketing amounts of lithium, copper, cobalt, and other materials. Around the world, businesses and governments are scrambling for new places and new ways to get those metals, at enormous cost to people and the planet. Beiser crisscrossed the world to talk to the people involved and report on the damage this race is inflicting, the ways it could get worse, and how we can minimize the damage.

It used to be that ravaging another country’s economy required blockading its ports and laying siege to its cities. Now all it takes is a statement posted online by the U.S. government. In Chokepoints, Edward Fishman, a former top State Department sanctions official, takes us deep into the back rooms of power to reveal the untold history of the last two decades of U.S. foreign policy, in which America renounced the gospel of globalization and waged a new kind of economic war.

Economic sanctions dominate the landscape of world politics today. First developed in the early twentieth century as a way of exploiting the flows of globalization to defend liberal internationalism, their appeal is that they function as an alternative to war. This view, however, ignores the dark paradox at their core: designed to prevent war, economic sanctions are modeled on devastating techniques of warfare.

How does a neural network become a brain? While neurobiologists investigate how nature accomplishes this feat, computer scientists interested in AI strive to achieve this through technology. The Self-Assembling Brain tells the stories of both fields, exploring the historical and modern approaches taken by the scientists pursuing answers to the quandary: What information is necessary to make an intelligent neural network? As Peter Robin Hiesinger argues, "the information problem" underlies both fields.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

In Mitochondria and the Future of Medicine, naturopathic doctor Lee Know tells the epic story of mitochondria - the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy.

Confused about AI and worried about what it means for your future and the future of the world? You’re not alone. AI is everywhere—and few things are surrounded by so much hype, misinformation, and misunderstanding. In AI Snake Oil, computer scientists Arvind Narayanan and Sayash Kapoor cut through the confusion to give you an essential understanding of how AI works, why it often doesn’t, where it might be useful or harmful, and when you should suspect that companies are using AI hype to sell AI snake oil—products that don’t work, and probably never will.

Leading futurist and OneShared.World founder Jamie Metzl explores how genome sequencing, gene editing, artificial intelligence, and other technologies are not only changing our lives, but catalyzing each other in radical and accelerating ways. These technologies have the potential to improve our health, feed billions of people, supercharge our economies, and store essential information for millions of years, but can also—if we are not careful—do immeasurable harm.

While cells are commonly considered the building block of living things, it is actually the communication between cells that brings us to life, controlling our bodies and brains, determining whether we are healthy or sick, and directly influencing how we think, feel, and behave. In The Secret Language of Cells, doctor and neuroscientist Jon Lieff lets us listen in on these conversations, and reveals their significance for everything from mental health to cancer.