A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

The knowledge of death is so terrifying that we live most of our lives in denial of it. One of the most difficult moments of childhood must be when each of us first realizes that not only we but all our loved ones will die—and there is nothing we can do about it. Or at least, there hasn’t been. Today, we are living through a revolution in biology. Giant strides are being made in understanding why we age—and why some species live longer than others. Could we eventually cheat disease and death and live for a very long time, possibly many times our current lifespan?

What explains the brain-body connection? How is it that something intangible like stress can really kill? How about the fact that we can and often do worry ourselves sick? And how can we take advantage of the mind’s connection to the body to reduce pain, boost physical performance, and even treat disease? Answer these questions and more in The Power of Mind over Body, a 12-lecture course that will change the way you think about physical health and the brain.

Dr. Topol’s unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons—from semaglutides to AI—that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving.

Epigenetics is the science of living DNA, charting the chemical pathways that spur DNA into action by turning genes on and off. While the Human Genome Project of the early 2000s was hailed as the key to understanding human heredity and disease, that historic effort was just the beginning. It has taken epigenetics to fill in the picture, explaining how the fixed code of our genome is implemented in countless living processes.

“Who are you?” Chances are you’d answer this question by describing the highlights of your personality and life experiences. But if you’d been asked this same question yesterday, you might have responded with a slightly different description. Does that mean you are a particular person today but were a different person yesterday? And what about tomorrow? Welcome to the slippery, shape-shifting nature of memory. As Professor Gabrielle Principe reveals, “you” are the conglomeration of the often-unreliable information your brain decides to feed you at any given moment.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

Simon Schama explores the mysterious contradictions of the Dutch nation that invented itself from the ground up, attained an unprecedented level of affluence, and lived in constant dread of being corrupted by happiness. Drawing on a vast array of period documents and sumptuously reproduced art, Schama recreates in precise detail a nation's mental state. He tells of bloody uprisings and beached whales, of the cult of hygiene and the plague of tobacco, of thrifty housewives and profligate tulip-speculators.

Eating is an indispensable human activity. As a result, whether we realize it or not, the drive to obtain food has been a major catalyst across all of history, from prehistoric times to the present. Epicure Jean-Anthelme Brillat-Savarin said it best: "Gastronomy governs the whole life of man."

In Waves in an Impossible Sea, physicist Matt Strassler tells a startling tale of elementary particles, human experience, and empty space. He begins with a simple mystery of motion. When we drive at highway speeds with the windows down, the wind beats against our faces. Yet our planet hurtles through the cosmos at 150 miles per second, and we feel nothing of it. How can our voyage be so tranquil when, as Einstein discovered, matter warps space, and space deflects matter? The answer, Strassler reveals, is that empty space is a sea, albeit a paradoxically strange one.

What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.

Conflict is increasing everywhere, threatening everything we hold dear—from our families to our democracy, from our workplaces to our world. In nearly every area of society, we are fighting more and collaborating less, especially over crucial problems that demand solutions. With this groundbreaking book, bestselling author and international negotiator William Ury shares a new “path to possible”—time-tested practices that will help listeners unlock their power to constructively engage and transform conflict.

In her memoir All That Remains, internationally renowned forensic anthropologist and human anatomist Dame Sue Black recounted her life lived eye to eye with the Grim Reaper. During the course of it, she offered a primer on the basics of identifying human remains, plenty of insights into the fascinating processes of death, and a sober, compassionate understanding of its inescapable presence in our existence. Now in this book, Black builds on that memoir, taking us on a guided tour of the human skeleton and explaining how each person's life history is revealed in their bones.

The hunt for the holy grail of healthy aging has been ongoing for hundreds of years, and Dr. Stephanie Venn-Watson may be its most unlikely champion. As a veterinary epidemiologist, she was recruited by the US Navy to lead a clinical research program to improve the health of Navy dolphins. Using advanced biotechnology to study the healthiest aging dolphins, she discovered C15:0, a saturated fat which has the potential to expand both the health-span and lifespan in long-lived mammals.

In The Dorito Effect, Mark Schatzker shows us how our approach to the nation's number-one public health crisis has gotten it wrong. The epidemics of obesity, heart disease, and diabetes are not tied to the overabundance of fat or carbs. Instead we have been led astray by the growing divide between flavor - the tastes we crave - and the underlying nutrition.