
Diet, Drugs, and Dopamine
The New Science of Achieving a Healthy Weight
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Narrated by:
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Hillary Huber
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David A. Kessler M.D.
About this listen
From the New York Times bestselling author of The End of Overeating comes an illuminating understanding of body weight, including the promise—and peril—of the latest weight loss drugs. This program features an introduction and epilogue read by the author.
The struggle is universal: we work hard to lose weight, only to find that it slowly creeps back. In America, body weight has become a pain point shrouded in self-recrimination and shame, not to mention bias from the medical community. For many, this battle not only takes a mental toll but also becomes a physical threat: three-quarters of American adults struggle with weight-related health conditions, including high blood pressure, heart disease, and diabetes. We know that diets don’t work, and yet we also know that excess weight starves us of years and quality of life. Where do we go from here?
In Diet, Drugs, and Dopamine, former FDA Commissioner Dr. David A. Kessler unpacks the mystery of weight in the most comprehensive work to date on this topic, giving listeners the power to dramatically improve their health. Kessler, who has himself struggled with weight, suggests the new class of GLP-1 weight loss drugs have provided a breakthrough: they have radically altered our understanding of weight loss. They make lasting change possible, but they also have real disadvantages and must be considered as part of a comprehensive approach together with nutrition, behavior, and physical activity.
Critical to this new perspective is the insight that weight-loss drugs act on the part of the brain that is responsible for cravings. In essence, the drugs tamp down the addictive circuits that overwhelm rational decision-making and quiet the “food noise” that distracts us. Identifying these mechanisms allows us to develop a strategy for effective long-term weight loss, and that begins with naming the elephant in the room: ultraformulated foods are addictive. Losing weight is a process of treating addiction.
In this landmark audiobook, one of the nation’s leading public health officials breaks taboos around this fraught conversation, giving listeners the tools to unplug the brain’s addictive wiring and change their relationship with food. Dr. Kessler cautions that drugs, on their own, pose serious risks and are not a universal solution. But with this new understanding of the brain-body feedback loop comes new possibilities for our health and freedom from a lifelong struggle.
Eye-opening, provocative, and rigorous, this is a must-listen for anyone who has ever struggled to maintain their weight—which is to say, everyone.
A Macmillan Audio production from Flatiron Books.
©2025 David A. Kessler (P)2025 Macmillan AudioListeners also enjoyed...
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Critic reviews
"Who could be better suited and more trustworthy than former FDA commissioner Dr. David A. Kessler to doggedly sort through the scientific evidence, cut through the hype, and bring us to a better understanding of our own body weight? Diet, Drugs, and Dopamine is eye-opening, beautifully crafted, full of practical insights, and a great read."—Abraham Verghese, New York Times bestselling author of The Covenant of Water
"A beautifully rendered and illuminating exploration of the disease of obesity that will change not only how we understand our health but also how we understand one another."—Siddhartha Mukherjee, MD, New York Times bestselling author of The Emperor of All Maladies
"A brilliant and incisive examination of one of our country's most vexing health challenges. Dr. Kessler's sharp scientific analysis cuts through the fog of confusion surrounding weight loss and offers a practical, sustainable pathway to better health. It is no surprise he is one of the great medical and public health leaders of our time."—Vivek H. Murthy, MD, 19th and 21st Surgeon General of the United States and New York Times bestselling author of Together
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Peloton. Pilates. Biohacking. Colonics. Ashwagandha. Today, the wellness industry is a $3.7 trillion behemoth that touches us all. In this timely and clear-eyed book, journalist Amy Larocca peels back the layers behind the wellness movement and reckons with its promises and profits. How did we get here and how did the idea of wellness become integrated with women's lives? And how did we end up spending so much money on products that may not work at all?
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Couldn’t finish it
- By Susan Smith on 06-03-25
By: Amy Larocca
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The Ultimate Rapid Weight Loss Hypnosis for Women Bundle
- Hypnosis, Visualizations, Positive Affirmations, and Hypnotic Gastric Band Everything You Need to Shed the Weight and Feel Great
- By: Natalie James
- Narrated by: Stacey
- Length: 10 hrs and 1 min
- Unabridged
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The Ultimate Rapid Weight Loss Hypnosis for Women Bundle is your all-in-one audio guide to achieving lasting weight loss through the power of hypnosis, guided visualizations, positive affirmations, and the transformative effects of the hypnotic gastric band. This comprehensive bundle is designed to reprogram your subconscious mind, helping you break free from unhealthy eating patterns, reduce cravings, and develop a natural desire for nourishing foods.
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Exactly the motivational boost I needed.
- By Sheri Peterson on 06-17-25
By: Natalie James
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The Dopamine Switch
- How to Rewire Your Brain to Reverse Digital Numbness, Brain Fog & Social Media Addiction: A Neuroplasticity Framework to Lasting Focus, Deep Connection & Feeling Fully Alive Again
- By: Cameron Hale
- Narrated by: Keong Sim
- Length: 5 hrs and 12 mins
- Unabridged
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You've tried productivity hacks, dopamine detoxes, and self-control, but they all miss the real issue. The more you fight distraction, the more exhausted and overwhelmed you feel. Traditional advice is built for a different brain. Most digital detox methods focus on restriction when the real key is restoring your brain's natural ability to feel joy without quitting technology or forcing extreme lifestyle changes. Using cutting-edge neuroplasticity techniques, this guide rewires your dopamine system so you naturally shift from mindless distraction to deep engagement, without upending your life.
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A New Path to Joy
- By Antoni Edwards on 06-13-25
By: Cameron Hale
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Align Your Mind
- Tame Your Inner Critic and Make Peace with Your Shadow Using the Power of Parts Work
- By: Britt Frank LSCSW
- Narrated by: Britt Frank LSCSW
- Length: 7 hrs and 53 mins
- Unabridged
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Grounded in the latest research on Parts Work and Internal Family Systems, and offering proven techniques from Frank’s clinical practice and personal challenges, this engaging guide is a user manual to your own mind—and presents a road map for finding peace, confidence, and a deeper understanding of who you truly are.
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Like having a therapist 24/7
- By Sharmin Banu on 06-14-25
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The Joy Reset
- Six Ways Trauma Steals Happiness and How to Win it Back
- By: Dr. MaryCatherine McDonald PhD
- Narrated by: Dr. MaryCatherine McDonald PhD
- Length: 6 hrs and 26 mins
- Unabridged
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In The Joy Reset, Dr. McDonald helps listeners identify barriers that prevent them from accessing joy—hypervigilance, emotional numbing, fear of loss, conditioning, guilt, and shame—and then redefines positive emotions as those tenacious, gritty, often tiny experiences that appear within the darkest moments and form the very foundation of psychological resilience.
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Super Agers
- By: Eric Topol
- Narrated by: Eric Topol
- Length: 14 hrs and 43 mins
- Unabridged
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Dr. Topol’s unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons—from semaglutides to AI—that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving.
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A Dense but Illuminating Map to Longer, Healthier Lives
- By LD on 05-11-25
By: Eric Topol
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Remembering Awake
- How to Love and Play Creation with Y/our Soul
- By: Julie Foster MD
- Narrated by: Julie Foster MD
- Length: 11 hrs and 19 mins
- Unabridged
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It is time for our soul to awaken to its true potential and collectively create a more loving reality. Remembering Awake is a guidebook on how to do that. It will help you understand how important and perfect your soul’s journey through time has been. It will help your mind relax and melt into harmony with all the dimensions of our consciousness. It will help you open the prisons your limbic system has placed you in and dissolve some of the amnesia that keeps you from remembering that only one unconditionally loving soul is here “playing Earth.
By: Julie Foster MD
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I Hate Myself
- Overcome Self-Loathing and Realize Why You're Wrong About You
- By: Blaise Aguirre MD
- Narrated by: Lee Goettl
- Length: 8 hrs and 18 mins
- Unabridged
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In I Hate Myself: Overcome Self-Hatred and Realize Why You're Wrong About You, internationally known assistant professor of psychiatry at Harvard Medical School Dr. Blaise Aguirre tackles the pervasive and often ignored issue of self-hatred. This book provides crucial insights into identifying and overcoming this deeply disturbing feeling, explaining why common practices of "self-care" or "self-love" often fall short in cases where self-hatred has become an integral part of a person's identity.
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The Obesity Code
- Unlocking the Secrets of Weight Loss
- By: Dr. Jason Fung
- Narrated by: Brian Nishii
- Length: 10 hrs and 9 mins
- Unabridged
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In this highly listenable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps - a set of lifelong habits that will improve your health and control your insulin levels - Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight - for good.
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There is a PDF, Folks
- By Cynthia on 06-27-17
By: Dr. Jason Fung
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Rapid Weight Loss Hypnosis 3-in-1
- End Emotional Eating, Build a Body You Love, & Rewire the Subconscious Patterns Keeping You Stuck - Without Willpower: How to Lose Weight Without Losing Yourself
- By: Isabelle Grey
- Narrated by: Robyn Mary Buedo
- Length: 10 hrs and 13 mins
- Unabridged
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What if the real breakthrough in weight loss wasn’t counting calories—but rewiring the cravings, habits, and self-judgment buried deep in your subconscious? You’ve tried diets. You’ve battled cravings. You’ve promised yourself “this time will be different.” But here you are—still feeling stuck in the same cycle. Rapid Weight Loss Hypnosis 3-in-1 isn’t another diet, another plan, or another drill sergeant telling you what to eat. It’s a different kind of journey—one that rewires your relationship with food, body, and self from the inside out.
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Peaceful, Motivating, and Very Effective
- By K-Stamp on 06-05-25
By: Isabelle Grey
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How Do You Choose?
- A Human Design Guide to What's Best for You at Work, in Love, and in Life
- By: Erin Claire Jones
- Narrated by: Erin Claire Jones
- Length: 6 hrs and 35 mins
- Unabridged
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Do you know what career you’re really meant to pursue? Can you identify the relationships you should really be investing in? Are you living your life to the fullest? Human Design is a mystical personality assessment that uses NASA data, astrology, and Eastern philosophy to generate mind-blowingly accurate insights into how you uniquely thrive at work, in love, and beyond.
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Every single part was amazing!
- By Amazon Customer on 06-16-25
How not to Diet
How not to Age
Dr. Michea Greger MD
Hold Plant Based
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Way too much.
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If Only the Author Could Have Narrated
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