
Diet, Drugs, and Dopamine
The New Science of Achieving a Healthy Weight
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Narrated by:
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Hillary Huber
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David A. Kessler M.D.
About this listen
From the New York Times bestselling author of The End of Overeating comes an illuminating understanding of body weight, including the promise—and peril—of the latest weight loss drugs. This program features an introduction and epilogue read by the author.
The struggle is universal: we work hard to lose weight, only to find that it slowly creeps back. In America, body weight has become a pain point shrouded in self-recrimination and shame, not to mention bias from the medical community. For many, this battle not only takes a mental toll but also becomes a physical threat: three-quarters of American adults struggle with weight-related health conditions, including high blood pressure, heart disease, and diabetes. We know that diets don’t work, and yet we also know that excess weight starves us of years and quality of life. Where do we go from here?
In Diet, Drugs, and Dopamine, former FDA Commissioner Dr. David A. Kessler unpacks the mystery of weight in the most comprehensive work to date on this topic, giving listeners the power to dramatically improve their health. Kessler, who has himself struggled with weight, suggests the new class of GLP-1 weight loss drugs have provided a breakthrough: they have radically altered our understanding of weight loss. They make lasting change possible, but they also have real disadvantages and must be considered as part of a comprehensive approach together with nutrition, behavior, and physical activity.
Critical to this new perspective is the insight that weight-loss drugs act on the part of the brain that is responsible for cravings. In essence, the drugs tamp down the addictive circuits that overwhelm rational decision-making and quiet the “food noise” that distracts us. Identifying these mechanisms allows us to develop a strategy for effective long-term weight loss, and that begins with naming the elephant in the room: ultraformulated foods are addictive. Losing weight is a process of treating addiction.
In this landmark audiobook, one of the nation’s leading public health officials breaks taboos around this fraught conversation, giving listeners the tools to unplug the brain’s addictive wiring and change their relationship with food. Dr. Kessler cautions that drugs, on their own, pose serious risks and are not a universal solution. But with this new understanding of the brain-body feedback loop comes new possibilities for our health and freedom from a lifelong struggle.
Eye-opening, provocative, and rigorous, this is a must-listen for anyone who has ever struggled to maintain their weight—which is to say, everyone.
A Macmillan Audio production from Flatiron Books.
©2025 David A. Kessler (P)2025 Macmillan AudioListeners also enjoyed...
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Critic reviews
"Who could be better suited and more trustworthy than former FDA commissioner Dr. David A. Kessler to doggedly sort through the scientific evidence, cut through the hype, and bring us to a better understanding of our own body weight? Diet, Drugs, and Dopamine is eye-opening, beautifully crafted, full of practical insights, and a great read."—Abraham Verghese, New York Times bestselling author of The Covenant of Water
"A beautifully rendered and illuminating exploration of the disease of obesity that will change not only how we understand our health but also how we understand one another."—Siddhartha Mukherjee, MD, New York Times bestselling author of The Emperor of All Maladies
"A brilliant and incisive examination of one of our country's most vexing health challenges. Dr. Kessler's sharp scientific analysis cuts through the fog of confusion surrounding weight loss and offers a practical, sustainable pathway to better health. It is no surprise he is one of the great medical and public health leaders of our time."—Vivek H. Murthy, MD, 19th and 21st Surgeon General of the United States and New York Times bestselling author of Together
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- Unlock the Secrets of Body Language, Mind Control, Gaslighting, NLP, Emotional Intelligence, Manipulation, and Covert Persuasion
- By: Lucian Thornfield
- Narrated by: Mark Lancaster Brandom Harrigan
- Length: 45 hrs and 38 mins
- Unabridged
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The Ultimate Guide to Dark Psychology and How to Analyze People is your definitive resource for mastering the subtle art of reading others and defending yourself against covert influence.
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Like finding gold in a bowl of peanuts
- By Angel Pineiro on 07-04-25
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Align Your Mind
- Tame Your Inner Critic and Make Peace with Your Shadow Using the Power of Parts Work
- By: Britt Frank LSCSW
- Narrated by: Britt Frank LSCSW
- Length: 7 hrs and 53 mins
- Unabridged
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Grounded in the latest research on Parts Work and Internal Family Systems, and offering proven techniques from Frank’s clinical practice and personal challenges, this engaging guide is a user manual to your own mind—and presents a road map for finding peace, confidence, and a deeper understanding of who you truly are.
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Like having a therapist 24/7
- By Sharmin Banu on 06-14-25
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Rapid Weight Loss Hypnosis 3-in-1
- End Emotional Eating, Build a Body You Love, & Rewire the Subconscious Patterns Keeping You Stuck - Without Willpower: How to Lose Weight Without Losing Yourself
- By: Isabelle Grey
- Narrated by: Robyn Mary Buedo
- Length: 10 hrs and 13 mins
- Unabridged
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What if the real breakthrough in weight loss wasn’t counting calories—but rewiring the cravings, habits, and self-judgment buried deep in your subconscious? You’ve tried diets. You’ve battled cravings. You’ve promised yourself “this time will be different.” But here you are—still feeling stuck in the same cycle. Rapid Weight Loss Hypnosis 3-in-1 isn’t another diet, another plan, or another drill sergeant telling you what to eat. It’s a different kind of journey—one that rewires your relationship with food, body, and self from the inside out.
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Slim Down with Hypnosis!
- By Ivy2023 on 07-07-25
By: Isabelle Grey
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The Obesity Code
- Unlocking the Secrets of Weight Loss
- By: Dr. Jason Fung
- Narrated by: Brian Nishii
- Length: 10 hrs and 9 mins
- Unabridged
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In this highly listenable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. In addition to his five basic steps - a set of lifelong habits that will improve your health and control your insulin levels - Dr. Fung explains how to use intermittent fasting to break the cycle of insulin resistance and reach a healthy weight - for good.
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There is a PDF, Folks
- By Cynthia on 06-27-17
By: Dr. Jason Fung
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The Dopamine Switch
- How to Rewire Your Brain to Reverse Digital Numbness, Brain Fog & Social Media Addiction: A Neuroplasticity Framework to Lasting Focus, Deep Connection & Feeling Fully Alive Again
- By: Cameron Hale
- Narrated by: Keong Sim
- Length: 5 hrs and 12 mins
- Unabridged
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You've tried productivity hacks, dopamine detoxes, and self-control, but they all miss the real issue. The more you fight distraction, the more exhausted and overwhelmed you feel. Traditional advice is built for a different brain. Most digital detox methods focus on restriction when the real key is restoring your brain's natural ability to feel joy without quitting technology or forcing extreme lifestyle changes. Using cutting-edge neuroplasticity techniques, this guide rewires your dopamine system so you naturally shift from mindless distraction to deep engagement, without upending your life.
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Helped Me Cut Screen Time
- By Daniel S on 07-01-25
By: Cameron Hale
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The Pink Salt Trick Recipe Bible
- The Ultimate Detox Ritual for Natural Weight Loss, Energy, and Wellness
- By: Amanda Wells
- Narrated by: Virtual Voice
- Length: 2 hrs and 32 mins
- Unabridged
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Can One Simple Morning Ritual Really Help You Detox, Lose Weight, and Feel Amazing? Feeling bloated, low-energy, or off balance lately? What if the secret to feeling lighter, more focused, and truly well… started with a glass of water and a pinch of salt?Welcome to the Pink Salt Trick—Your New Wellness Ritual The Pink Salt Trick Recipe Bible is more than a health guide—it's a daily ritual that blends ancient Ayurvedic wisdom with modern simplicity. This book walks you through the science and soul of a detox method that's gaining popularity for good reason: it works. Rooted in the ...
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Easy Life Changing Ritual
- By LK Elam on 06-12-25
By: Amanda Wells
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The Joy Reset
- Six Ways Trauma Steals Happiness and How to Win it Back
- By: Dr. MaryCatherine McDonald PhD
- Narrated by: Dr. MaryCatherine McDonald PhD
- Length: 6 hrs and 26 mins
- Unabridged
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In The Joy Reset, Dr. McDonald helps listeners identify barriers that prevent them from accessing joy—hypervigilance, emotional numbing, fear of loss, conditioning, guilt, and shame—and then redefines positive emotions as those tenacious, gritty, often tiny experiences that appear within the darkest moments and form the very foundation of psychological resilience.
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Outsmarting Obesity
- A Doctor Reveals Why We Gain Weight, Why It Matters, and What We Can Do About It
- By: Stewart Lonky MD
- Narrated by: Josh Horowitz
- Length: 10 hrs and 5 mins
- Unabridged
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In Outsmarting Obesity, pioneering physician Dr. Stewart Lonky gives us a fresh look at the obesity challenge with an explanation of the science behind his groundbreaking approach. He explains how epigenetics, our modern environment, and our toxic behaviors have created the perfect obesity storm, imperiling our physical, financial, and psychological well-being.
By: Stewart Lonky MD
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Super Agers
- By: Eric Topol
- Narrated by: Eric Topol
- Length: 14 hrs and 43 mins
- Unabridged
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Dr. Topol’s unprecedented, evidenced-based guide is about how you and your family and friends can benefit from new treatments coming available at a faster rate than ever. From his unique position as a leader overseeing millions in research funding, Dr. Topol also explains the fundamental reasons—from semaglutides to AI—that we can be confident these breakthroughs will continue. Ninety-five percent of Americans over sixty have at least one chronic disease and almost as many have two. That is the essential problem this revolution is solving.
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A Dense but Illuminating Map to Longer, Healthier Lives
- By LD on 05-11-25
By: Eric Topol
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Your Brain on Dopamine
- Heal Your Overstimulated Brain, Master Your Cravings, and Find Purpose and Meaning in a World of Distraction
- By: Matthew Reed
- Narrated by: Virtual Voice
- Length: 4 hrs and 23 mins
- Unabridged
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Do you ever feel like certain behaviors have more sway over you than you would like? Are you often distracted and find it difficult to focus on important tasks for more than a few minutes? Do you find yourself mindlessly scrolling through social media or reaching for a sugary snack whenever you're bored or feeling down? Even though the challenges of today's fast-paced world can impact your life in myriad ways, one thing is clear: you are not alone! In fact, in an era of unparalleled wealth, freedom, technological advancement, and medical innovation, depression and anxiety rates are ...
By: Matthew Reed
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Raising Intuitive Eaters
- By: Sarah Remmer, The Great Courses
- Narrated by: Sarah Remmer
- Length: 3 hrs and 13 mins
- Original Recording
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How can we combat the negative habits and feelings that surround our food choices? And how can we give our kids a healthier alternative to the anxiety of restrictive diets and encourage them to listen to what their bodies need? The answer may lie with “intuitive eating”, a mind-body approach to eating that has been shown to improve diet quality, self-esteem, mental health, fitness motivation, and more.
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Some good tips, some sanctimonious propaganda
- By Alice on 09-18-23
By: Sarah Remmer, and others
Way too much.
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Helped me make informed decision
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Very informative
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How not to Diet
How not to Age
Dr. Michea Greger MD
Hold Plant Based
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Practical Information - Science Explained
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If Only the Author Could Have Narrated
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Simply not that good
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