
The Breakthrough
Immunotherapy and the Race to Cure Cancer
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Narrated by:
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Will Collyer
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Charles Graeber
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By:
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Charles Graeber
About this listen
Follow along as this New York Times best-selling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this "captivating and heartbreaking" book (The Wall Street Journal).
For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold?
As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses - tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment", a revolutionary discovery in our understanding of cancer and how to beat it.
In The Breakthrough, New York Times best-selling author of The Good Nurse Charles Graeber guides listeners through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of 21st-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step - harnessing the wealth of new information to create modern and more effective patient therapies - is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease.
Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
PLEASE NOTE: When you purchase this title, the accompanying PDF will be available in your Audible Library along with the audio.
©2018 Charles Graeber (P)2018 Hachette AudioListeners also enjoyed...
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Critic reviews
"Graeber concisely reviews the science of cancer...The risks of tinkering with an intricate immune system are obviously high, even perilous. But the potential reward is a cure. Exciting reading." (Booklist)
"There is no villain more ruthless than cancer, which has robbed us all of loved ones who had to endure untold suffering before they succumbed. But after decades of frustration and toil, scientists finally understand how to vanquish the disease by activating the human body's natural defenses. The intimate stories behind this triumph lie at the heart of Charles Graeber's The Breakthrough, an expertly crafted and exhilarating account of life-saving ingenuity at its most dazzling. You will never encounter another book so incisive about the art of medical sleuthing, or so poetic about our innate drive to hold on to all that's beautiful in this world for as long as we can." (Brendan I. Koerner, Wired contributing editor and author of The Skies Belong to Us)
"[A] deft, detailed study of cancer immunotherapy.... From the once-discredited pioneer William Coley to immunologist and Nobel laureate James P. Allison, they form a brilliant, driven, admirably stubborn group that Graeber brings vividly to life." (Nature)
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Amazing narration, moving story!
- By Suzanne B on 04-03-22
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Jungle of Stone
- The True Story of Two Men, Their Extraordinary Journey, and the Discovery of the Lost Civilization of the Maya
- By: William Carlsen
- Narrated by: Paul Michael Garcia
- Length: 16 hrs and 35 mins
- Unabridged
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In 1839 rumors of extraordinary yet baffling stone ruins buried within the unmapped jungles of Central America reached two of the world's most intrepid travelers. Seized by the reports, American diplomat John Lloyd Stephens and British artist Frederick Catherwood sailed together out of New York Harbor on an expedition into the forbidding rainforests of present-day Honduras, Guatemala, and Mexico. What they found would rewrite the West's understanding of human history.
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Lacking on adventure, misleading title
- By Allen on 02-23-17
By: William Carlsen
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Founder vs Investor
- The Honest Truth About Venture Capital from Startup to IPO
- By: Elizabeth Joy Zalman, Jerry Neumann
- Narrated by: Elizabeth Joy Zalman, Jerry Neumann, Andrew Magnusson
- Length: 6 hrs and 56 mins
- Unabridged
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Every iconic tech company was once a startup. And while these companies like to paint an origin story full of surefooted confidence, the truth is usually something different: the early life of most startups is pure chaos. This chaos comes from the vastly different motivations and incentives between those with the vision and those with the money. From fundraising paranoia to boardroom coups, Zalman and Neumann train their inimitable voices on the gulf between what founders and investors promise to do and what they end up actually doing.
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Well narrated and straight to the point book
- By Zoryana Tischenko on 06-18-25
By: Elizabeth Joy Zalman, and others
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Collective Illusions
- Conformity, Complicity, and the Science of Why We Make Bad Decisions
- By: Todd Rose
- Narrated by: Jay Ben Markson
- Length: 7 hrs and 25 mins
- Unabridged
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Drawing on cutting-edge neuroscience, behavioral economic, and social psychology research, acclaimed author, former Harvard professor, and think tank founder Todd Rose reveals how so much of our thinking about each other is informed by false assumptions that drive bad decisions that make us dangerously mistrustful as a society and hopelessly unhappy as individuals.
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starts well but later deviates from the subject
- By Mats Bengtsson on 06-15-22
By: Todd Rose
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The Glutathione Revolution
- Fight Disease, Slow Aging, and Increase Energy with the Master Antioxidant
- By: Nayan Patel PharmD, Dr. Mark Hyman MD - foreword
- Narrated by: Gary Tiedemann
- Length: 7 hrs and 15 mins
- Unabridged
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Ward off life-threatening disease and symptoms of aging with this guide to boosting your levels of glutathione (GHS), the "master antioxidant".
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Excellent book on Glutathione!
- By AmazonCustomer on 03-06-21
By: Nayan Patel PharmD, and others
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The Song of the Cell
- An Exploration of Medicine and the New Human
- By: Siddhartha Mukherjee
- Narrated by: Dennis Boutsikaris
- Length: 16 hrs and 3 mins
- Unabridged
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From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.
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Beyond Words Wonderful
- By Lynn on 11-27-22
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Immunology - Medical School Crash Course
- By: AudioLearn Medical Content Team
- Narrated by: Bhama Roget
- Length: 6 hrs and 49 mins
- Unabridged
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Written by experts and authorities in the field and professionally narrated for easy listening, this crash course is a valuable tool both during school and when preparing for the USMLE, or if you're simply interested in the subject of human Immunology. The audio is focused and high-yield, covering the most important topics you might expect to learn in a typical medical school Immunology course. Included are both capsule and detailed explanations of critical issues and topics you must know to master the course.
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Better than the anatomy version
- By Stewart on 02-11-18
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1453
- The Holy War for Constantinople and the Clash of Islam and the West
- By: Roger Crowley
- Narrated by: Simon Prebble
- Length: 10 hrs and 56 mins
- Unabridged
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The fall of Constantinople in 1453 signaled a shift in history and the end of the Byzantium Empire. Roger Crowley's listenable and comprehensive account of the battle between Mehmed II, sultan of the Ottoman Empire, and Constantine XI, the 57th emperor of Byzantium, illuminates the period in history that was a precursor to the current jihad between the West and the Middle East.
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A well written narrative with bizarre and biased commentary
- By Patrick D. Flynn on 08-17-17
By: Roger Crowley
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Dynasty
- The Rise and Fall of the House of Caesar
- By: Tom Holland
- Narrated by: Derek Perkins
- Length: 16 hrs and 5 mins
- Unabridged
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Author and historian Tom Holland returns to his roots in Roman history and the audience he cultivated with Rubicon—his masterful, witty, brilliantly researched popular history of the fall of the Roman republic—with Dynasty, a luridly fascinating history of the reign of the first five Roman emperors. Dynasty continues Rubicon's story, opening where that book ended: with the murder of Julius Caesar. This is the period of the first and perhaps greatest Roman emperors. It's a colorful story of rule and ruination, from the rise of Augustus to the death of Nero.
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Accessible, enjoyable history
- By Mary on 01-28-16
By: Tom Holland
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Vertical Marriage
- The One Secret That Will Change Your Marriage
- By: John Driver - contributor, Dennis Rainey - foreword, Barbara Rainey - foreword, and others
- Narrated by: Ann Wilson, Dave Wilson, Dennis Rainey
- Length: 6 hrs and 41 mins
- Unabridged
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As founders of a multicampus church and marriage coaches with 30 years of experience, Dave and Ann share the hard-earned but easy-to-apply biblical principles that ensure a strong marriage. Written in a funny and highly relatable dialogue between both husband and wife, Vertical Marriage will guide you toward building a vibrant relationship at every level including communication, conflict, intimacy, and romance - though Dave is still figuring that last one out.
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Learned so much!
- By Linda Sue on 02-07-19
By: John Driver - contributor, and others
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Consider the Lobster
- And Other Essays
- By: David Foster Wallace
- Narrated by: Robert Petkoff, David Foster Wallace
- Length: 15 hrs and 8 mins
- Unabridged
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Do lobsters feel pain? Did Franz Kafka have a funny bone? What is John Updike's deal, anyway? And what happens when adult video starlets meet their fans in person? David Foster Wallace answers these questions and more in essays that are also enthralling narrative adventures.
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How this differs from the other version
- By Jonathan Penley on 12-26-17
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Immune
- A Journey into the Mysterious System That Keeps You Alive
- By: Philipp Dettmer
- Narrated by: Steve Taylor
- Length: 10 hrs and 28 mins
- Unabridged
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You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.
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Steve Taylor for the win
- By Bay Area Engineer on 11-02-21
By: Philipp Dettmer
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The Habsburgs
- To Rule the World
- By: Martyn Rady
- Narrated by: Simon Boughey
- Length: 14 hrs and 58 mins
- Unabridged
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The definitive history of a powerful family dynasty who dominated Europe for centuries - from their rise to power to their eventual downfall.
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An Excellent and Interesting History
- By Darrel Bishop on 09-14-20
By: Martyn Rady
Good intro to immunotherapy
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One of the strengths of the book is Graeber's ability to tell a compelling story. He profiles a number of patients who have been treated with immunotherapy, and he describes their experiences in vivid detail. This helps the reader to understand the human cost of cancer, and it also makes the science come alive.
Another strength of the book is Graeber's willingness to confront the difficult questions that immunotherapy raises. For example, he discusses the ethical implications of using the immune system to attack healthy cells, and he also raises concerns about the potential for immunotherapy to exacerbate racial disparities in healthcare.
Overall, The Breakthrough is an excellent book that provides a comprehensive overview of the science and history of immunotherapy. It is a must-read for anyone who is interested in cancer treatment or in the future of medicine.
However, there are a few areas where the book could be improved. First, Graeber could have done a better job of explaining the technical aspects of immunotherapy. Some of the concepts he discusses are quite complex, and it would have been helpful if he had provided more detail.
Second, Graeber could have been more balanced in his coverage of the potential benefits and risks of immunotherapy. He tends to focus on the potential benefits, and he does not discuss the risks as extensively. This could give the reader a false impression of the risks of immunotherapy.
Overall, The Breakthrough is an excellent book that provides a comprehensive overview of the science and history of immunotherapy. It is a must-read for anyone who is interested in cancer treatment or in the future of medicine.
Starter Story on Immunotherapy
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Surprisingly gripping
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A brief update of cancer therapy for the public
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Current research on immunotherapy
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Inspiring + Informational Cancer Treatment Stories
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An excellent introduction for lay people into the world of immunotherapy for cancer treatment
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It was also like an immunotherapy primer with a gripping tale.
After all, what is more gripping than real life.
Also my humblest thanks to those who dedicate themselves to finding solutions to this deadly disease!
Inspiring and informative
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Excellent
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Excellent.
Well done
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